Imperial College London

ProfessorAndrewBush

Faculty of MedicineNational Heart & Lung Institute

Professor of Paediatric Respirology
 
 
 
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Contact

 

+44 (0)20 7352 8121 ext 2255a.bush

 
 
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Location

 

Chelsea WingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

777 results found

Andersson CK, Adams A, Nagakumar P, Bossley C, Gupta A, De Vries D, Adnan A, Bush A, Saglani S, Lloyd CMet al., 2017, Intraepithelial neutrophils in pediatric severe asthma are associated with better lung function, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 139, Pages: 1819-+, ISSN: 0091-6749

JOURNAL ARTICLE

Arigliani M, Raywood E, Verger N, Negreskul Y, Duncan J, Bush A, Aurora Pet al., 2017, Shortened Multiple Breath Washout Is Not Suitable for Scond Calculation in Patients with Cystic Fibrosis., PEDIATRIC PULMONOLOGY, Vol: 52, Pages: S154-S154, ISSN: 8755-6863

JOURNAL ARTICLE

Artiso L, Walker S, Fleming L, Bush A, Saglani S, Nagakumar Pet al., 2017, Sputum Eosinophil Peroxidase (EPX) Differentiates Pediatric Severe Therapy Resistant Asthma (STRA) from Difficult Asthma (DA)., PEDIATRIC PULMONOLOGY, Vol: 52, Pages: S105-S106, ISSN: 8755-6863

JOURNAL ARTICLE

Brugha R, Hall A, Bush A, 2017, It ain't necessarily so: a surprising lower airway infection, THORAX, Vol: 72, Pages: 96-97, ISSN: 0040-6376

JOURNAL ARTICLE

Bush A, 2017, Markers of Severity in Difficult-To-Treat Asthma, PEDIATRIC PULMONOLOGY, Vol: 52, Pages: S36-S37, ISSN: 8755-6863

JOURNAL ARTICLE

Bush A, 2017, Diffuse lung disease in children: transcending continental boundaries, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 21, Pages: 837-839, ISSN: 1027-3719

JOURNAL ARTICLE

Bush A, Custovic A, 2017, Formula one: best is no formula, EUROPEAN RESPIRATORY JOURNAL, Vol: 49, ISSN: 0903-1936

JOURNAL ARTICLE

Bush A, Fleming L, Saglani S, 2017, Severe asthma in children, RESPIROLOGY, Vol: 22, Pages: 886-897, ISSN: 1323-7799

JOURNAL ARTICLE

Bush A, Pavord ID, 2017, After the asthmas: Star Wars and Star Trek, EUROPEAN RESPIRATORY JOURNAL, Vol: 50, ISSN: 0903-1936

JOURNAL ARTICLE

Bush A, Saglani S, Fleming L, 2017, Severe asthma: looking beyond the amount of medication., Lancet Respir Med

JOURNAL ARTICLE

Cook J, Beresford F, Fainardi V, Hall P, Housley G, Jamalzadeh A, Nightingale M, Winch D, Bush A, Fleming L, Saglani Set al., 2017, Managing the pediatric patient with refractory asthma: a multidisciplinary approach, JOURNAL OF ASTHMA AND ALLERGY, Vol: 10, Pages: 123-130, ISSN: 1178-6965

JOURNAL ARTICLE

De Simoni A, Horne R, Fleming L, Bush A, Griffiths Cet al., 2017, What do adolescents with asthma really think about adherence to inhalers? Insights from a qualitative analysis of a UK online forum, BMJ OPEN, Vol: 7, ISSN: 2044-6055

JOURNAL ARTICLE

Griese M, Seidl E, Hengst M, Reu S, Rock H, Anthony G, Kiper N, Emiralio─člu N, Snijders D, Goldbeck L, Leidl R, Ley-Zaporozhan J, Kr├╝ger-Stollfuss I, Kammer B, Wesselak T, Eismann C, Schams A, Neuner D, MacLean M, Nicholson AG, Lauren M, Clement A, Epaud R, de Blic J, Ashworth M, Aurora P, Calder A, Wetzke M, Kappler M, Cunningham S, Schwerk N, Bush A, and the other chILD-EU collaboratorset al., 2017, International management platform for children's interstitial lung disease (chILD-EU)., Thorax

BACKGROUND: Children's interstitial lung diseases (chILD) cover many rare entities, frequently not diagnosed or studied in detail. There is a great need for specialised advice and for internationally agreed subclassification of entities collected in a register.Our objective was to implement an international management platform with independent multidisciplinary review of cases at presentation for long-term follow-up and to test if this would allow for more accurate diagnosis. Also, quality and reproducibility of a diagnostic subclassification system were assessed using a collection of 25 complex chILD cases. METHODS: A web-based chILD management platform with a registry and biobank was successfully designed and implemented. RESULTS: Over a 3-year period, 575 patients were included for observation spanning a wide spectrum of chILD. In 346 patients, multidisciplinary reviews were completed by teams at five international sites (Munich 51%, London 12%, Hannover 31%, Ankara 1% and Paris 5%). In 13%, the diagnosis reached by the referring team was not confirmed by peer review. Among these, the diagnosis initially given was wrong (27%), imprecise (50%) or significant information was added (23%).The ability of nine expert clinicians to subcategorise the final diagnosis into the chILD-EU register classification had an overall exact inter-rater agreement of 59% on first assessment and after training, 64%. Only 10% of the 'wrong' answers resulted in allocation to an incorrect category. Subcategorisation proved useful but training is needed for optimal implementation. CONCLUSIONS: We have shown that chILD-EU has generated a platform to help the clinical assessment of chILD. TRIAL REGISTRATION NUMBER: Results, NCT02852928.

JOURNAL ARTICLE

Halvorsen T, Walsted ES, Bucca C, Bush A, Cantarella G, Friedrich G, Herth FJF, Hull JH, Jung H, Maat R, Nordang L, Remacle M, Rasmussen N, Wilson JA, Heimdal J-Het al., 2017, Inducible laryngeal obstruction: an official joint European Respiratory Society and European Laryngological Society statement, EUROPEAN RESPIRATORY JOURNAL, Vol: 50, ISSN: 0903-1936

JOURNAL ARTICLE

Hashimoto S, Brinkman P, Lefaudeux D, Bansal A, De Meulder B, Murray C, Bush A, Frey U, Singer F, Hedlin G, Nordlund B, Bisgaard H, Van Aalderen W, Vissing N, Zolkipli Z, Selby A, Fowler S, Shaw D, Sousa A, Wagers S, Corfield J, Pandis I, Rowe A, Valls MP, Pratico G, Auffray C, Chung KF, Bel E, Sterk PJ, Fleming L, Roberts Get al., 2017, Clinical Phenotypes Of Asthma In Childhood And Adolescence: Clustering Analysis From The Paediatric U-Biopred Cohorts, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Irving S, Carr S, Hogg C, Loebinger M, Shoemark A, Bush Aet al., 2017, Lung Clearance Index (LCI) is Stable in Most Primary Ciliary Dyskinesia (PCD) Patients Managed in a Specialist Centre: a Pilot Study, LUNG, Vol: 195, Pages: 441-443, ISSN: 0341-2040

JOURNAL ARTICLE

Lucas JS, Barbato A, Collins SA, Goutaki M, Behan L, Caudri D, Dell S, Eber E, Escudier E, Hirst RA, Hogg C, Jorissen M, Latzin P, Legendre M, Leigh MW, Midulla F, Nielsen KG, Omran H, Papon J-F, Pohunek P, Redfern B, Rigau D, Rindlisbacher B, Santamaria F, Shoemark A, Snijders D, Tonia T, Titieni A, Walker WT, Werner C, Bush A, Kuehni CEet al., 2017, European Respiratory Society guidelines for the diagnosis of primary ciliary dyskinesia, EUROPEAN RESPIRATORY JOURNAL, Vol: 49, ISSN: 0903-1936

JOURNAL ARTICLE

Makrinioti H, Bush A, Xepapadaki P, Malietzis G, Johnston S, Tsolia M, Papaevangelou V, Papadopoulos Net al., 2017, The role of viruses in post-bronchiolitis wheezing/asthma development-a systematic review and meta-analysis, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY, Pages: 492-492, ISSN: 0105-4538

CONFERENCE PAPER

Nagakumar P, Artusio L, Fainardi V, Fleming L, Bush A, Lloyd CM, Saglani Set al., 2017, Role Of Airway Ilc2 And Ilc3 Compared To Th2 And Th17 Cells In Paediatric Severe Therapy Resistant Asthma (stra), International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Olcese C, Patel MP, Shoemark A, Kiviluoto S, Legendre M, Williams HJ, Vaughan CK, Hayward J, Goldenberg A, Emes RD, Munye MM, Dyer L, Cahill T, Bevillard J, Gehrig C, Guipponi M, Chantot S, Duquesnoy P, Thomas L, Jeanson L, Copin B, Tamalet A, Thauvin-Robinet C, Papon J-F, Garin A, Pin I, Vera G, Aurora P, Fassad MR, Jenkins L, Boustred C, Cullup T, Dixon M, Onoufriadis A, Bush A, Chung EMK, Antonarakis SE, Loebinger MR, Wilson R, Armengot M, Escudier E, Hogg C, Amselem S, Sun Z, Bartoloni L, Blouin J-L, Mitchison HMet al., 2017, X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3, NATURE COMMUNICATIONS, Vol: 8, ISSN: 2041-1723

JOURNAL ARTICLE

Pavord ID, Beasley R, Agusti A, Anderson GP, Bel E, Brusselle G, Cullinan P, Custovic A, Ducharme FM, Fahy JV, Frey U, Gibson P, Heaney LG, Holt PG, Humbert M, Lloyd CM, Marks G, Martinez FD, Sly PD, von Mutius E, Wenzel S, Zar HJ, Bush Aet al., 2017, After asthma: redefining airways diseases., Lancet

JOURNAL ARTICLE

Pifferi M, Bush A, Caramella D, Metelli MR, Di Cicco M, Piras M, Gherarducci G, Capristo C, Maggi F, Peroni D, Boner ALet al., 2017, Matrix metalloproteinases and airway remodeling and function in primary ciliary dyskinesia, RESPIRATORY MEDICINE, Vol: 124, Pages: 49-56, ISSN: 0954-6111

JOURNAL ARTICLE

Puranik S, Forno E, Bush A, Celedon JCet al., 2017, Predicting Severe Asthma Exacerbations in Children, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 195, Pages: 854-859, ISSN: 1073-449X

JOURNAL ARTICLE

Saglani S, Bush A, 2017, Asthma Attacks in Children: Does Blocking IgE Reduce Rhinovirus Infections?, Am J Respir Crit Care Med, Vol: 196, Pages: 941-942

JOURNAL ARTICLE

Saunders C, Bayfield K, Irving S, Short C, Bush A, Davies JCet al., 2017, Developments in multiple breath washout testing in children with cystic fibrosis, CURRENT MEDICAL RESEARCH AND OPINION, Vol: 33, Pages: 613-620, ISSN: 0300-7995

JOURNAL ARTICLE

Shoemark A, Frost E, Dixon M, Ollosson S, Kilpin K, Patel M, Scully J, Rogers AV, Mitchison HM, Bush A, Hogg Cet al., 2017, Accuracy of Immunofluorescence in the Diagnosis of Primary Ciliary Dyskinesia, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 196, Pages: 94-101, ISSN: 1073-449X

JOURNAL ARTICLE

Shoemark A, Moya E, Hirst RA, Patel MP, Robson EA, Hayward J, Scully J, Fassad MR, Lamb W, Schmidts M, Dixon M, Patel-King RS, Rogers AV, Rutman A, Jackson CL, Goggin P, Rubbo B, Ollosson S, Carr S, Walker W, Adler B, Loebinger MR, Wilson R, Bush A, Williams H, Boustred C, Jenkins L, Sheridan E, Chung EMK, Watson CM, Cullup T, Lucas JS, Kenia P, O'Callaghan C, King SM, Hogg C, Mitchison HMet al., 2017, High prevalence of CCDC103 p.His154Pro mutation causing primary ciliary dyskinesia disrupts protein oligomerisation and is associated with normal diagnostic investigations., Thorax

RATIONALE: Primary ciliary dyskinesia is a genetically heterogeneous inherited condition characterised by progressive lung disease arising from abnormal cilia function. Approximately half of patients have situs inversus. The estimated prevalence of primary ciliary dyskinesia in the UK South Asian population is 1:2265. Early, accurate diagnosis is key to implementing appropriate management but clinical diagnostic tests can be equivocal. OBJECTIVES: To determine the importance of genetic screening for primary ciliary dyskinesia in a UK South Asian population with a typical clinical phenotype, where standard testing is inconclusive. METHODS: Next-generation sequencing was used to screen 86 South Asian patients who had a clinical history consistent with primary ciliary dyskinesia. The effect of a CCDC103 p.His154Pro missense variant compared with other dynein arm-associated gene mutations on diagnostic/phenotypic variability was tested. CCDC103 p.His154Pro variant pathogenicity was assessed by oligomerisation assay. RESULTS: Sixteen of 86 (19%) patients carried a homozygous CCDC103 p.His154Pro mutation which was found to disrupt protein oligomerisation. Variable diagnostic test results were obtained including normal nasal nitric oxide levels, normal ciliary beat pattern and frequency and a spectrum of partial and normal dynein arm retention. Fifteen (94%) patients or their sibling(s) had situs inversus suggesting CCDC103 p.His154Pro patients without situs inversus are missed. CONCLUSIONS: The CCDC103 p.His154Pro mutation is more prevalent than previously thought in the South Asian community and causes primary ciliary dyskinesia that can be difficult to diagnose using pathology-based clinical tests. Genetic testing is critical when there is a strong clinical phenotype with inconclusive standard diagnostic tests.

JOURNAL ARTICLE

Simmonds NJ, Bush A, 2017, The Man in the Paper Mask: One (Mask) for All and All for…..Cystic Fibrosis?, Am J Respir Crit Care Med

JOURNAL ARTICLE

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