Imperial College London

ProfessorAndrewBush

Faculty of MedicineNational Heart & Lung Institute

Professor of Paediatric Respirology
 
 
 
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Contact

 

+44 (0)20 7352 8121 ext 2255a.bush

 
 
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Location

 

Chelsea WingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

835 results found

Ahmed B, Cox MJ, Cuthbertson L, James PL, Cookson WOC, Davies JC, Moffatt MF, Bush Aet al., 2018, Comparison of the upper and lower airway microbiota in children with chronic lung diseases, PLOS ONE, Vol: 13, ISSN: 1932-6203

JOURNAL ARTICLE

Bardin EE, Cameron SJS, Perdones-Montero A, Hardiman K, Bolt F, Alton EWFW, Bush A, Davies JC, Takats Zet al., 2018, Metabolic Phenotyping and Strain Characterisation of Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients Using Rapid Evaporative Ionisation Mass Spectrometry, SCIENTIFIC REPORTS, Vol: 8, ISSN: 2045-2322

JOURNAL ARTICLE

Brandsma J, Goss VM, Yang X, Bakke PS, Caruso M, Chanez P, Dahlen S-E, Fowler SJ, Horvath I, Krug N, Montuschi P, Sanak M, Sandstrom T, Shaw DE, Chung KF, Singer F, Fleming LJ, Sousa AR, Pandis I, Bansal AT, Sterk PJ, Djukanovic R, Postle ADet al., 2018, Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers, METABOLOMICS, Vol: 14, ISSN: 1573-3882

JOURNAL ARTICLE

Buelo A, McLean S, Julious S, Flores-Kim J, Bush A, Henderson J, Paton JY, Sheikh A, Shields M, Pinnock Het al., 2018, At-risk children with asthma (ARC): a systematic review, THORAX, Vol: 73, Pages: 813-824, ISSN: 0040-6376

JOURNAL ARTICLE

Bush A, 2018, Low Lung Function in Young Adult Life Is Associated with Early Mortality, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 197, Pages: 538-539, ISSN: 1073-449X

JOURNAL ARTICLE

Bush A, 2018, Translating Asthma: Dissecting the Role of Metabolomics, Genomics and Personalized Medicine, INDIAN JOURNAL OF PEDIATRICS, Vol: 85, Pages: 643-650, ISSN: 0019-5456

JOURNAL ARTICLE

Bush A, 2018, A scandal in South Africa: And not just there!, PEDIATRIC PULMONOLOGY, Vol: 53, Pages: 698-700, ISSN: 8755-6863

JOURNAL ARTICLE

Bush A, 2018, Management of asthma in children., Minerva Pediatr, Vol: 70, Pages: 444-457

This manuscript takes a challenging look at the management of asthma in childhood, in particular in the light of the recent Lancet commission. One of the central pillars of the Commission is the need to deliver personalized medicine for airway disease by deconstructing the airway into components of fixed and variable airflow obstruction, inflammation and infection. Before any treatment for asthma, a diagnostic workup is essential to exclude other conditions. A diagnosis of asthma needs to be based on objective evidence of bronchodilator sensitive variable airflow obstruction, eosinophilic airway inflammation and atopy. Most children with atopic asthma respond to low dose inhaled corticosteroids, sometimes requiring a long acting β-agonist. If the response is unsatisfactory, then, rather than escalate treatment, an approach for which there is little evidence, a full review of the child should be undertaken, including extrapulmonary comorbidities, adherence and adverse environmental influences. If these cannot or will not be addressed by the family, then further treatment including biologicals may be indicated. Asthma attacks are an important warning sign and should always be taken seriously, including a focused reassessment of all aspects of the management of the child. Finally, preschool children with wheeze can also be evaluated for eosinophilic airway inflammation using peripheral blood eosinophil count as a surrogate. It is essential that we start to deliver personalized medicine to children with airway disease.

JOURNAL ARTICLE

Bush A, 2018, What Sort of Asthma Do I Have?, Publisher: WILEY, Pages: S9-S11, ISSN: 8755-6863

CONFERENCE PAPER

Bush A, 2018, DIFFICULT ASTHMA, CURRENT ALLERGY & CLINICAL IMMUNOLOGY, Vol: 31, Pages: 118-122, ISSN: 1609-3607

JOURNAL ARTICLE

Bush A, 2018, Out of Sight, but Should Not Be Out of Mind: The Hidden Lung Blood Supply., Ann Am Thorac Soc, Vol: 15, Pages: 1284-1285

JOURNAL ARTICLE

Bush A, Pavord ID, 2018, 'We can't diagnose asthma until < insert arbitrary age >', ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 103, Pages: 729-731, ISSN: 0003-9888

JOURNAL ARTICLE

Bush A, Saglani S, 2018, Structurally Unsound? Why Airways Become Asthmatic, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 59, Pages: 405-406, ISSN: 1044-1549

JOURNAL ARTICLE

Castro-Rodriguez JA, Saglani S, Rodriguez-Martinez CE, Oyarzun MA, Fleming L, Bush Aet al., 2018, The relationship between inflammation and remodeling in childhood asthma: A systematic review, PEDIATRIC PULMONOLOGY, Vol: 53, Pages: 824-835, ISSN: 8755-6863

JOURNAL ARTICLE

Chang AB, Bush A, Grimwood K, 2018, Bronchiectasis in children: diagnosis and treatment, LANCET, Vol: 392, Pages: 866-879, ISSN: 0140-6736

JOURNAL ARTICLE

Davies G, Stanojevic S, Stocks J, Lum S, Bush A, Duncan J, Raywood E, Viviani L, Wade A, Aurora Pet al., 2018, PRE-SCHOOL LCI IS AN INDICATOR OF LUNG FUNCTION IN ADOLESCENCE: FINDINGS FROM THE LONDON CYSTIC FIBROSIS COLLABORATION, Publisher: WILEY, Pages: 326-326, ISSN: 8755-6863

CONFERENCE PAPER

Dehlink E, Richardson C, Marsh G, Lee K, Jamalzadeh A, Bush A, Hogg C, Carr SBet al., 2018, Are inhaled corticosteroids prescribed rationally in primary ciliary dyskinesia?, EUROPEAN RESPIRATORY JOURNAL, Vol: 51, ISSN: 0903-1936

JOURNAL ARTICLE

Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmueller J, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, Bisgaard H, Bjornsdottir US, Bleecker E, Bonnelykke K, Boomsma DI, Bouzigon E, Brightling CE, Brossard M, Brusselle GG, Burchard E, Burkart KM, Bush A, Chan-Yeung M, Chung KF, Alves AC, Curtin JA, Custovic A, Daley D, de Jongste JC, Del-Rio-Navarro BE, Donohue KM, Duijts L, Eng C, Eriksson JG, Farrall M, Fedorova Y, Feenstra B, Ferreira MA, Freidin MB, Gajdos Z, Gauderman J, Gehring U, Geller F, Genuneit J, Gharib SA, Gilliland F, Granell R, Graves PE, Gudbjartsson DF, Haahtela T, Heckbert SR, Heederik D, Heinrich J, Heliovaara M, Henderson J, Himes BE, Hirose H, Hirschhorn JN, Hofman A, Holt P, Hottenga J, Hudson TJ, Hui J, Imboden M, Ivanov V, Jaddoe VWV, James A, Janson C, Jarvelin M-R, Jarvis D, Jones G, Jonsdottir I, Jousilahti P, Kabesch M, Kahonen M, Kantor DB, Karunas AS, Khusnutdinova E, Koppelman GH, Kozyrskyj AL, Kreiner E, Kubo M, Kumar R, Kumar A, Kuokkanen M, Lahousse L, Laitinen T, Laprise C, Lathrop M, Lau S, Lee Y-A, Lehtimaki T, Letort S, Levin AM, Li G, Liang L, Loehr LR, London SJ, Loth DW, Manichaikul A, Marenholz I, Martinez FJ, Matheson MC, Mathias RA, Matsumoto K, Mbarek H, McArdle WL, Melbye M, Melen E, Meyers D, Michel S, Mohamdi H, Musk AW, Myers RA, Nieuwenhuis MAE, Noguchi E, O'Connor GT, Ogorodova LM, Palmer CD, Palotie A, Park JE, Pennell CE, Pershagen G, Polonikov A, Postma DS, Probst-Hensch N, Puzyrev VP, Raby BA, Raitakari OT, Ramasamy A, Rich SS, Robertson CF, Romieu I, Salam MT, Salomaa V, Schlunssen V, Scott R, Selivanova PA, Sigsgaard T, Simpson A, Siroux V, Smith LJ, Solodilova M, Standl M, Stefansson K, Strachan DP, Stricker BH, Takahashi A, Thompson PJ, Thorleifsson G, Thorsteinsdottir U, Tiesler CMT, Torgerson DG, Tsunoda T, Uitterlinden AG, van der Valk RJP, Vaysse A, Vedantam S, von Berg A, von Mutius E, Vonk JM, Waage J, Wareham NJ, Weiss ST, White WB, Wickman M, Widen E, Willemsen G, Williams LK, Wouterset al., 2018, Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks, NATURE GENETICS, Vol: 50, Pages: 42-+, ISSN: 1061-4036

JOURNAL ARTICLE

Griese M, Seidl E, Hengst M, Reu S, Rock H, Anthony G, Kiper N, Emiralioglu N, Snijders D, Goldbeck L, Leidl R, Ley-Zaporozhan J, Krueger-Stollfuss I, Kammer B, Wesselak T, Eismann C, Schams A, Neuner D, MacLean M, Nicholson AG, Lauren M, Clement A, Epaud R, de Blic J, Ashworth M, Aurora P, Calder A, Wetzke M, Kappler M, Cunningham S, Schwerk N, Bush Aet al., 2018, International management platform for children's interstitial lung disease (chILD-EU), THORAX, Vol: 73, Pages: 231-239, ISSN: 0040-6376

JOURNAL ARTICLE

Hekking P-P, Loza MJ, Pavlidis S, de Meulder B, Lefaudeux D, Baribaud F, Auffray C, Wagener AH, Brinkman P, Lutter R, Bansal AT, Sousa AR, Bates SA, Pandis Y, Fleming LJ, Shaw DE, Fowler SJ, Guo Y, Meiser A, Sun K, Corfield J, Howarth PH, Bel EH, Adcock IM, Chung KF, Djukanovic R, Sterk PJet al., 2018, Pathway discovery using transcriptomic profiles in adult-onset severe asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 141, Pages: 1280-1290, ISSN: 0091-6749

JOURNAL ARTICLE

Irving S, Dixon M, Fassad MR, Frost E, Hayward J, Kilpin K, Ollosson S, Onoufriadis A, Patel MP, Scully J, Carr SB, Mitchison HM, Loebinger MR, Hogg C, Shoemark A, Bush Aet al., 2018, Primary Ciliary Dyskinesia Due to Microtubular Defects is Associated with Worse Lung Clearance Index, LUNG, Vol: 196, Pages: 231-238, ISSN: 0341-2040

JOURNAL ARTICLE

Jevnikar Z, Östling J, Ax E, Calvén J, Thörn K, Israelsson E, Öberg L, Singhania A, Lau LCK, Wilson SJ, Ward JA, Chauhan A, Sousa AR, De Meulder B, Loza MJ, Baribaud F, Sterk PJ, Chung KF, Sun K, Guo Y, Adcock IM, Payne D, Dahlen B, Chanez P, Shaw DE, Krug N, Hohlfeld JM, Sandström T, Djukanovic R, James A, Hinks TSC, Howarth PH, Vaarala O, van Geest M, Olsson H, Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes study groupet al., 2018, Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation., J Allergy Clin Immunol

BACKGROUND: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in asthmatic patients is unclear. OBJECTIVE: We sought to explore the association between epithelial IL-6TS pathway activation and molecular and clinical phenotypes in asthmatic patients. METHODS: An IL-6TS gene signature obtained from air-liquid interface cultures of human bronchial epithelial cells stimulated with IL-6 and sIL-6R was used to stratify lung epithelial transcriptomic data (Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes [U-BIOPRED] cohorts) by means of hierarchical clustering. IL-6TS-specific protein markers were used to stratify sputum biomarker data (Wessex cohort). Molecular phenotyping was based on transcriptional profiling of epithelial brushings, pathway analysis, and immunohistochemical analysis of bronchial biopsy specimens. RESULTS: Activation of IL-6TS in air-liquid interface cultures reduced epithelial integrity and induced a specific gene signature enriched in genes associated with airway remodeling. The IL-6TS signature identified a subset of patients with IL-6TS-high asthma with increased epithelial expression of IL-6TS-inducible genes in the absence of systemic inflammation. The IL-6TS-high subset had an overrepresentation of frequent exacerbators, blood eosinophilia, and submucosal infiltration of T cells and macrophages. In bronchial brushings Toll-like receptor pathway genes were upregulated, whereas expression of cell junction genes was reduced. Sputum sIL-6R and IL-6 levels correlated with sputum markers of remodeling and innate immune activation, in particular YKL-40, matrix metalloproteinase 3, macrophage inflammatory protein 1β, IL-8, and IL-1β. CONCLUSIONS: Local lung epithelial IL-6TS activation in the absence of type 2 airway inflammation defines a novel subset of asthmatic patients and might drive airway inflamma

JOURNAL ARTICLE

Lenney W, Bush A, Fitzgerald DA, Fletcher M, Ostrem A, Pedersen S, Szefler SJ, Zar HJet al., 2018, Improving the global diagnosis and management of asthma in children, THORAX, Vol: 73, Pages: 662-669, ISSN: 0040-6376

JOURNAL ARTICLE

McKibben S, De Simoni A, Bush A, Thomas M, Griffiths Cet al., 2018, The use of electronic alerts in primary care computer systems to identify the excessive prescription of short-acting beta(2)-agonists for people with asthma: a systematic review, NPJ PRIMARY CARE RESPIRATORY MEDICINE, Vol: 28, ISSN: 2055-1010

JOURNAL ARTICLE

Nagakumar P, Gambir N, Sanghani N, Hall P, Jamalzadeh A, Beresford F, Saglani S, Bush A, Fleming Let al., 2018, Role of a prolonged inpatient admission when evaluating children with problematic severe asthma, EUROPEAN RESPIRATORY JOURNAL, Vol: 51, ISSN: 0903-1936

JOURNAL ARTICLE

Pavord ID, Beasley R, Agusti A, Anderson GP, Bel E, Brusselle G, Cullinan P, Custovic A, Ducharme FM, Fahy JV, Frey U, Gibson P, Heaney LG, Holt PG, Humbert M, Lloyd CM, Marks G, Martinez FD, Sly PD, von Mutius E, Wenzel S, Zar HJ, Bush Aet al., 2018, After asthma: redefining airways diseases, LANCET, Vol: 391, Pages: 350-400, ISSN: 0140-6736

JOURNAL ARTICLE

Pearce C, Chan A, Horne R, Fleming L, Bush A, Jamalzadeh Aet al., 2018, "IT'S LIKE TRYING TO FIT A PIECE INTO AN ALREADY NOT WORKING PUZZLE": NON ADHERENCE TO INHALED CORTICOSTEROIDS IN YOUNG PEOPLE WITH PROBLEMATIC ASTHMA: A QUALITATIVE STUDY, Publisher: SPRINGER, Pages: S191-S191, ISSN: 1070-5503

CONFERENCE PAPER

Pearce CJ, Chan A, Horne R, Fleming L, Bush A, Jackson Tet al., 2018, WHAT ARE THE EFFECTIVE ASPECTS OF ADHERENCE INTERVENTIONS FOR INHALED CORTICOSTEROIDS IN CHILDREN WITH ASTHMA?: A SYSTEMATIC REVIEW, Publisher: SPRINGER, Pages: S166-S166, ISSN: 1070-5503

CONFERENCE PAPER

Pifferi M, Bush A, Rizzo M, Tonacci A, Di Cicco M, Piras M, Maggi F, Paiola G, Michelucci A, Cangiotti A, Peroni D, Caramella D, Boner ALet al., 2018, Olfactory dysfunction is worse in primary ciliary dyskinesia compared with other causes of chronic sinusitis in children, THORAX, Vol: 73, Pages: 980-982, ISSN: 0040-6376

JOURNAL ARTICLE

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