Imperial College London

ProfessorAndrewBush

Faculty of MedicineNational Heart & Lung Institute

Professor of Paediatric Respirology
 
 
 
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Contact

 

+44 (0)20 7352 8121 ext 2255a.bush

 
 
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Location

 

Chelsea WingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

791 results found

Bush A, Pavord ID, 2018, 'We can't diagnose asthma until <insert arbitrary age>'., Arch Dis Child

JOURNAL ARTICLE

Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmueller J, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, Bisgaard H, Bjornsdottir US, Bleecker E, Bonnelykke K, Boomsma DI, Bouzigon E, Brightling CE, Brossard M, Brusselle GG, Burchard E, Burkart KM, Bush A, Chan-Yeung M, Chung KF, Alves AC, Curtin JA, Custovic A, Daley D, de Jongste JC, Del-Rio-Navarro BE, Donohue KM, Duijts L, Eng C, Eriksson JG, Farrall M, Fedorova Y, Feenstra B, Ferreira MA, Freidin MB, Gajdos Z, Gauderman J, Gehring U, Geller F, Genuneit J, Gharib SA, Gilliland F, Granell R, Graves PE, Gudbjartsson DF, Haahtela T, Heckbert SR, Heederik D, Heinrich J, Heliovaara M, Henderson J, Himes BE, Hirose H, Hirschhorn JN, Hofman A, Holt P, Hottenga J, Hudson TJ, Hui J, Imboden M, Ivanov V, Jaddoe VWV, James A, Janson C, Jarvelin M-R, Jarvis D, Jones G, Jonsdottir I, Jousilahti P, Kabesch M, Kahonen M, Kantor DB, Karunas AS, Khusnutdinova E, Koppelman GH, Kozyrskyj AL, Kreiner E, Kubo M, Kumar R, Kumar A, Kuokkanen M, Lahousse L, Laitinen T, Laprise C, Lathrop M, Lau S, Lee Y-A, Lehtimaki T, Letort S, Levin AM, Li G, Liang L, Loehr LR, London SJ, Loth DW, Manichaikul A, Marenholz I, Martinez FJ, Matheson MC, Mathias RA, Matsumoto K, Mbarek H, McArdle WL, Melbye M, Melen E, Meyers D, Michel S, Mohamdi H, Musk AW, Myers RA, Nieuwenhuis MAE, Noguchi E, O'Connor GT, Ogorodova LM, Palmer CD, Palotie A, Park JE, Pennell CE, Pershagen G, Polonikov A, Postma DS, Probst-Hensch N, Puzyrev VP, Raby BA, Raitakari OT, Ramasamy A, Rich SS, Robertson CF, Romieu I, Salam MT, Salomaa V, Schlunssen V, Scott R, Selivanova PA, Sigsgaard T, Simpson A, Siroux V, Smith LJ, Solodilova M, Standl M, Stefansson K, Strachan DP, Stricker BH, Takahashi A, Thompson PJ, Thorleifsson G, Thorsteinsdottir U, Tiesler CMT, Torgerson DG, Tsunoda T, Uitterlinden AG, van der Valk RJP, Vaysse A, Vedantam S, von Berg A, von Mutius E, Vonk JM, Waage J, Wareham NJ, Weiss ST, White WB, Wickman M, Widen E, Willemsen G, Williams LK, Wouterset al., 2018, Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks, NATURE GENETICS, Vol: 50, Pages: 42-+, ISSN: 1061-4036

JOURNAL ARTICLE

Irving S, Dixon M, Fassad MR, Frost E, Hayward J, Kilpin K, Ollosson S, Onoufriadis A, Patel MP, Scully J, Carr SB, Mitchison HM, Loebinger MR, Hogg C, Shoemark A, Bush Aet al., 2018, Primary Ciliary Dyskinesia Due to Microtubular Defects is Associated with Worse Lung Clearance Index., Lung

PURPOSE: Primary ciliary dyskinesia (PCD) is characterised by repeated upper and lower respiratory tract infections, neutrophilic airway inflammation and obstructive airway disease. Different ultrastructural ciliary defects may affect lung function decline to different degrees. Lung clearance index (LCI) is a marker of ventilation inhomogeneity that is raised in some but not all patients with PCD. We hypothesised that PCD patients with microtubular defects would have worse (higher) LCI than other PCD patients. METHODS: Spirometry and LCI were measured in 69 stable patients with PCD. Age at testing, age at diagnosis, ethnicity, ciliary ultrastructure, genetic screening result and any growth of Pseudomonas aeruginosa was recorded. RESULTS: Lung clearance index was more abnormal in PCD patients with microtubular defects (median 10.24) than those with dynein arm defects (median 8.3, p = 0.004) or normal ultrastructure (median 7.63, p = 0.0004). Age is correlated with LCI, with older patients having worse LCI values (p = 0.03, r = 0.3). CONCLUSION: This study shows that cilia microtubular defects are associated with worse LCI in PCD than dynein arm defects or normal ultrastructure. The patient's age at testing is also associated with a higher LCI. Patients at greater risk of obstructive lung disease should be considered for more aggressive management. Differences between patient groups may potentially open avenues for novel treatments.

JOURNAL ARTICLE

Nagakumar P, Gambir N, Sanghani N, Hall P, Jamalzadeh A, Beresford F, Saglani S, Bush A, Fleming Let al., 2018, Role of a prolonged inpatient admission when evaluating children with problematic severe asthma., Eur Respir J, Vol: 51

JOURNAL ARTICLE

Pavord ID, Beasley R, Agusti A, Anderson GP, Bel E, Brusselle G, Cullinan P, Custovic A, Ducharme FM, Fahy JV, Frey U, Gibson P, Heaney LG, Holt PG, Humbert M, Lloyd CM, Marks G, Martinez FD, Sly PD, von Mutius E, Wenzel S, Zar HJ, Bush Aet al., 2018, After asthma: redefining airways diseases, LANCET, Vol: 391, Pages: 350-400, ISSN: 0140-6736

JOURNAL ARTICLE

Shoemark A, Moya E, Hirst RA, Patel MP, Robson EA, Hayward J, Scully J, Fassad MR, Lamb W, Schmidts M, Dixon M, Patel-King RS, Rogers AV, Rutman A, Jackson CL, Goggin P, Rubbo B, Ollosson S, Carr S, Walker W, Adler B, Loebinger MR, Wilson R, Bush A, Williams H, Boustred C, Jenkins L, Sheridan E, Chung EMK, Watson CM, Cullup T, Lucas JS, Kenia P, O'Callaghan C, King SM, Hogg C, Mitchison HMet al., 2018, High prevalence of CCDC103 p.His154Pro mutation causing primary ciliary dyskinesia disrupts protein oligomerisation and is associated with normal diagnostic investigations, THORAX, Vol: 73, Pages: 157-166, ISSN: 0040-6376

JOURNAL ARTICLE

Simmonds NJ, Bush A, 2018, The Man in the Paper Mask: One (Mask) for All and All for . . . Cystic Fibrosis?, Am J Respir Crit Care Med, Vol: 197, Pages: 281-283

JOURNAL ARTICLE

Andersson CK, Adams A, Nagakumar P, Bossley C, Gupta A, De Vries D, Adnan A, Bush A, Saglani S, Lloyd CMet al., 2017, Intraepithelial neutrophils in pediatric severe asthma are associated with better lung function, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 139, Pages: 1819-+, ISSN: 0091-6749

JOURNAL ARTICLE

Arigliani M, Raywood E, Verger N, Negreskul Y, Duncan J, Bush A, Aurora Pet al., 2017, Shortened Multiple Breath Washout Is Not Suitable for Scond Calculation in Patients with Cystic Fibrosis., PEDIATRIC PULMONOLOGY, Vol: 52, Pages: S154-S154, ISSN: 8755-6863

JOURNAL ARTICLE

Artiso L, Walker S, Fleming L, Bush A, Saglani S, Nagakumar Pet al., 2017, Sputum Eosinophil Peroxidase (EPX) Differentiates Pediatric Severe Therapy Resistant Asthma (STRA) from Difficult Asthma (DA)., PEDIATRIC PULMONOLOGY, Vol: 52, Pages: S105-S106, ISSN: 8755-6863

JOURNAL ARTICLE

Bousquet J, Farrell J, Crooks G, Hellings P, Bel EH, Bewick M, Chavannes NH, de Sousa JC, Cruz AA, Haahtela T, Joos G, Khaltaev N, Malva J, Muraro A, Nogues M, Palkonen S, Pedersen S, Robalo-Cordeiro C, Samolinski B, Strandberg T, Valiulis A, Yorgancioglu A, Zuberbier T, Bedbrook A, Aberer W, Adachi M, Agusti A, Akdis CA, Akdis M, Ankri J, Alonso A, Annesi-Maesano I, Ansotegui IJ, Anto JM, Arnavielhe S, Arshad H, Bai C, Baiardini I, Bachert C, Baigenzhin AK, Barbara C, Bateman ED, Beghe B, Ben Kheder A, Bennoor KS, Benson M, Bergmann KC, Bieber T, Bindslev-Jensen C, Bjermer L, Blain H, Blasi F, Boner AL, Bonini M, Bonini S, Bosnic-Anticevitch S, Boulet LP, Bourret R, Bousquet PJ, Braido F, Briggs AH, Brightling CE, Brozek J, Buhl R, Burney PG, Bush A, Caballero-Fonseca F, Caimmi D, Calderon MA, Calverley PM, Camargos PAM, Canonica GW, Camuzat T, Carlsen KH, Carr W, Carriazo A, Casale T, Sarabia AMC, Chatzi L, Chen YZ, Chiron R, Chkhartishvili E, Chuchalin AG, Chung KF, Ciprandi G, Cirule I, Cox L, Costa DJ, Custovic A, Dahl R, Dahlen SE, Darsow U, De Carlo G, De Blay F, Dedeu T, Deleanu D, Keenoy EDM, Demoly P, Denburg JA, Devillier P, Didier A, Dinh-Xuan AT, Djukanovic R, Dokic D, Douagui H, Dray G, Dubakiene R, Durham SR, Dykewicz MS, El-Gamal Y, Emuzyte R, Fabbri LM, Fletcher M, Fiocchi A, Wagner AF, Fonseca J, Fokkens WJ, Forastiere F, Frith P, Gaga M, Gamkrelidze A, Garces J, Garcia-Aymerich J, Gemicioglu B, Gereda JE, Diaz SG, Gotua M, Grisle I, Grouse L, Gutter Z, Guzman MA, Heaney LG, Hellquist-Dahl B, Henderson D, Hendry A, Heinrich J, Heve D, Horak F, Hourihane JOB, Howarth P, Humbert M, Hyland ME, Illario M, Ivancevich JC, Jardim JR, Jares EJ, Jeandel C, Jenkins C, Johnston SL, Jonquet O, Julge K, Jung KS, Just J, Kaidashev I, Khaitov MR, Kalayci O, Kalyoncu AF, Keil T, Keith PK, Klimek L, N'Goran BK, Kolek V, Koppelman GH, Kowalski ML, Kull I, Kuna P, Kvedariene V, Lambrecht B, Lau S, Larenas-Linnemann D, Laune D, Le LTT, Lieberman P, Lipworth B, Li J Cet al., 2017, Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5) (vol 6, 29, 2016), CLINICAL AND TRANSLATIONAL ALLERGY, Vol: 7, ISSN: 2045-7022

JOURNAL ARTICLE

Brugha R, Hall A, Bush A, 2017, It ain't necessarily so: a surprising lower airway infection, THORAX, Vol: 72, Pages: 96-97, ISSN: 0040-6376

JOURNAL ARTICLE

Bush A, 2017, Markers of Severity in Difficult-To-Treat Asthma, PEDIATRIC PULMONOLOGY, Vol: 52, Pages: S36-S37, ISSN: 8755-6863

JOURNAL ARTICLE

Bush A, 2017, Diffuse lung disease in children: transcending continental boundaries, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 21, Pages: 837-839, ISSN: 1027-3719

JOURNAL ARTICLE

Bush A, 2017, Evidence-based approach to congenital thoracic malformations, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 102, Pages: 1095-1095, ISSN: 0003-9888

JOURNAL ARTICLE

Bush A, 2017, Translating Asthma: Dissecting the Role of Metabolomics, Genomics and Personalized Medicine., Indian J Pediatr

The management of asthma has largely stagnated over the last 25 years, but we are at the dawning of a new age wherein -omics technology can help us manage the disease objectively and rationally. Even in this new scientific age, getting the basics of asthma management right remains essential. The new technologies which can be applied to multiple biological samples include genomics (study of the genome), transcriptomics (gene transcription), lipidomics, proteomics and metabolomics (lipids, proteins and metabolites, respectively) and breathomics, using exhaled breath as a source of biomarkers, which is of particular interest in view of its non-invasive nature in pediatrics. Important applications will include the diagnosis of airways disease, including its components; the pathways driving airway pathology; monitoring the response to treatment; and measuring future risk (asthma attacks, poor lung growth trajectory). With the advent of a wide range of novel biologicals to treat asthma, -omics technology to personalize therapy will be especially important. The U-BIOPRED (Europe) and SARP (USA) groups have been most active in this field, especially using bronchoscopically obtained samples to perform cluster analyses to define new asthma endotypes. However, stability over time and consistency between investigators is imperfect. This is perhaps unsurprising; results of biomarker studies in asthma will be a composite of the underlying disease, the (variable) effects of adverse drivers such as allergen exposure and pollution, the effects of treatment, and the effects of adherence or otherwise to treatment. Ultimately, the aim should be an exhaled breath based tool with a rapid result that can be used as a routine in the clinic. However, at the moment, there are as yet no clinical applications in children of -omics technology.

JOURNAL ARTICLE

Bush A, 2017, Persistent Bacterial Bronchitis: time to venture beyond the Umbrella, FRONTIERS IN PEDIATRICS, Vol: 5, ISSN: 2296-2360

JOURNAL ARTICLE

Bush A, Custovic A, 2017, Formula one: best is no formula, EUROPEAN RESPIRATORY JOURNAL, Vol: 49, ISSN: 0903-1936

JOURNAL ARTICLE

Bush A, Fleming L, Saglani S, 2017, Severe asthma in children, RESPIROLOGY, Vol: 22, Pages: 886-897, ISSN: 1323-7799

JOURNAL ARTICLE

Bush A, Griffiths C, 2017, Improving treatment of asthma attacks in children UK children and young people have the highest death rate from asthma in Europe, BMJ-BRITISH MEDICAL JOURNAL, Vol: 359, ISSN: 1756-1833

JOURNAL ARTICLE

Bush A, Pavord ID, 2017, After the asthmas: Star Wars and Star Trek, EUROPEAN RESPIRATORY JOURNAL, Vol: 50, ISSN: 0903-1936

JOURNAL ARTICLE

Bush A, Saglani S, Fleming L, 2017, Severe asthma: looking beyond the amount of medication, LANCET RESPIRATORY MEDICINE, Vol: 5, Pages: 844-846, ISSN: 2213-2600

JOURNAL ARTICLE

Cook J, Beresford F, Fainardi V, Hall P, Housley G, Jamalzadeh A, Nightingale M, Winch D, Bush A, Fleming L, Saglani Set al., 2017, Managing the pediatric patient with refractory asthma: a multidisciplinary approach, JOURNAL OF ASTHMA AND ALLERGY, Vol: 10, Pages: 123-130, ISSN: 1178-6965

JOURNAL ARTICLE

Davies G, Stocks J, Thia LP, Hoo A-F, Bush A, Aurora P, Brennan L, Lee S, Lum S, Cottam P, Miles J, Chudleigh J, Kirkby J, Balfour-Lynn IM, Carr SB, Wallis C, Wyatt H, Wade Aet al., 2017, Pulmonary function deficits in newborn screened infants with cystic fibrosis managed with standard UK care are mild and transient, EUROPEAN RESPIRATORY JOURNAL, Vol: 50, ISSN: 0903-1936

JOURNAL ARTICLE

De Simoni A, Horne R, Fleming L, Bush A, Griffiths Cet al., 2017, What do adolescents with asthma really think about adherence to inhalers? Insights from a qualitative analysis of a UK online forum, BMJ OPEN, Vol: 7, ISSN: 2044-6055

JOURNAL ARTICLE

Griese M, Seidl E, Hengst M, Reu S, Rock H, Anthony G, Kiper N, Emiralio─člu N, Snijders D, Goldbeck L, Leidl R, Ley-Zaporozhan J, Kr├╝ger-Stollfuss I, Kammer B, Wesselak T, Eismann C, Schams A, Neuner D, MacLean M, Nicholson AG, Lauren M, Clement A, Epaud R, de Blic J, Ashworth M, Aurora P, Calder A, Wetzke M, Kappler M, Cunningham S, Schwerk N, Bush A, and the other chILD-EU collaboratorset al., 2017, International management platform for children's interstitial lung disease (chILD-EU)., Thorax

BACKGROUND: Children's interstitial lung diseases (chILD) cover many rare entities, frequently not diagnosed or studied in detail. There is a great need for specialised advice and for internationally agreed subclassification of entities collected in a register.Our objective was to implement an international management platform with independent multidisciplinary review of cases at presentation for long-term follow-up and to test if this would allow for more accurate diagnosis. Also, quality and reproducibility of a diagnostic subclassification system were assessed using a collection of 25 complex chILD cases. METHODS: A web-based chILD management platform with a registry and biobank was successfully designed and implemented. RESULTS: Over a 3-year period, 575 patients were included for observation spanning a wide spectrum of chILD. In 346 patients, multidisciplinary reviews were completed by teams at five international sites (Munich 51%, London 12%, Hannover 31%, Ankara 1% and Paris 5%). In 13%, the diagnosis reached by the referring team was not confirmed by peer review. Among these, the diagnosis initially given was wrong (27%), imprecise (50%) or significant information was added (23%).The ability of nine expert clinicians to subcategorise the final diagnosis into the chILD-EU register classification had an overall exact inter-rater agreement of 59% on first assessment and after training, 64%. Only 10% of the 'wrong' answers resulted in allocation to an incorrect category. Subcategorisation proved useful but training is needed for optimal implementation. CONCLUSIONS: We have shown that chILD-EU has generated a platform to help the clinical assessment of chILD. TRIAL REGISTRATION NUMBER: Results, NCT02852928.

JOURNAL ARTICLE

Halvorsen T, Walsted ES, Bucca C, Bush A, Cantarella G, Friedrich G, Herth FJF, Hull JH, Jung H, Maat R, Nordang L, Remacle M, Rasmussen N, Wilson JA, Heimdal J-Het al., 2017, Inducible laryngeal obstruction: an official joint European Respiratory Society and European Laryngological Society statement, EUROPEAN RESPIRATORY JOURNAL, Vol: 50, ISSN: 0903-1936

JOURNAL ARTICLE

Hashimoto S, Brinkman P, Lefaudeux D, Bansal A, De Meulder B, Murray C, Bush A, Frey U, Singer F, Hedlin G, Nordlund B, Bisgaard H, Van Aalderen W, Vissing N, Zolkipli Z, Selby A, Fowler S, Shaw D, Sousa A, Wagers S, Corfield J, Pandis I, Rowe A, Valls MP, Pratico G, Auffray C, Chung KF, Bel E, Sterk PJ, Fleming L, Roberts Get al., 2017, Clinical Phenotypes Of Asthma In Childhood And Adolescence: Clustering Analysis From The Paediatric U-Biopred Cohorts, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

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