803 results found
Bush A, 2018, Low Lung Function in Young Adult Life Is Associated with Early Mortality, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 197, Pages: 538-539, ISSN: 1073-449X
Bush A, 2018, A scandal in South Africa: And not just there!, Pediatr Pulmonol
Bush A, Pavord ID, 2018, 'We can't diagnose asthma until <insert arbitrary age>'., Arch Dis Child
Castro-Rodriguez JA, Saglani S, Rodriguez-Martinez CE, et al., 2018, The relationship between inflammation and remodeling in childhood asthma: A systematic review., Pediatr Pulmonol
OBJECTIVES: We aimed to perform a systematic review of all studies with direct measurements of both airway inflammation and remodeling in the subgroup of children with repeated wheezing and/or persistent asthma severe enough to warrant bronchoscopy, to address whether airway inflammation precedes remodeling or is a parallel process, and also to assess the impact of remodeling on lung function. METHODS: Four databases were searched up to June 2017. Two independent reviewers screened the literature and extracted relevant data. RESULTS: We found 526 references, and 39 studies (2390 children under 18 years old) were included. Airway inflammation (eosinophilic/neutrophilic) and remodeling were not present in wheezers at a mean age of 12 months, but in older pre-school children (mean 2.5 years), remodeling (mainly increased reticular basement membrane [RBM] thickness and increased area of airway smooth muscle) and also airway eosinophilia was reported. This was worse in school-age children. RBM thickness was similar in atopic and non-atopic preschool wheezers. Airway remodeling was correlated with lung function in seven studies, with FeNO in three, and with HRCT-scan in one. Eosinophilic inflammation was not seen in patients without remodeling. There were no invasive longitudinal or intervention studies. CONCLUSION: The relationship between inflammation and remodeling in children cannot be determined. Failure to demonstrate eosinophilic inflammation in the absence of remodeling is contrary to the hypothesis that inflammation causes these changes. We need reliable, non-invasive markers of remodeling in particular if this is to be addressed.
Dehlink E, Richardson C, Marsh G, et al., 2018, Are inhaled corticosteroids prescribed rationally in primary ciliary dyskinesia?, EUROPEAN RESPIRATORY JOURNAL, Vol: 51, ISSN: 0903-1936
Demenais F, Margaritte-Jeannin P, Barnes KC, et al., 2018, Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks, NATURE GENETICS, Vol: 50, Pages: 42-+, ISSN: 1061-4036
Griese M, Seidl E, Hengst M, et al., 2018, International management platform for children's interstitial lung disease (chILD-EU), THORAX, Vol: 73, Pages: 231-239, ISSN: 0040-6376
Irving S, Dixon M, Fassad MR, et al., 2018, Primary Ciliary Dyskinesia Due to Microtubular Defects is Associated with Worse Lung Clearance Index, LUNG, Vol: 196, Pages: 231-238, ISSN: 0341-2040
McKibben S, De Simoni A, Bush A, et al., 2018, The use of electronic alerts in primary care computer systems to identify the excessive prescription of short-acting beta(2)-agonists for people with asthma: a systematic review, NPJ PRIMARY CARE RESPIRATORY MEDICINE, Vol: 28, ISSN: 2055-1010
Nagakumar P, Gambir N, Sanghani N, et al., 2018, Role of a prolonged inpatient admission when evaluating children with problematic severe asthma, EUROPEAN RESPIRATORY JOURNAL, Vol: 51, ISSN: 0903-1936
Pifferi M, Bush A, Rizzo M, et al., 2018, Olfactory dysfunction is worse in primary ciliary dyskinesia compared with other causes of chronic sinusitis in children., Thorax
Cilia have multiple functions including olfaction. We hypothesised that olfactory function could be impaired in primary ciliary dyskinesia (PCD). Olfaction, nasal nitric oxide (nNO) and sinus CT were assessed in patients with PCD and non-PCD sinus disease, and healthy controls (no CT scan). PCD and non-PCD patients had similar severity of sinus disease. Despite this, defective olfaction was more common in patients with PCD (P<0.0001) and more severe in patients with PCD with major Transmission Electron Microscopy (TEM) abnormalities. Only in classical PCD did olfaction inversely correlate with sinusitis and nNO. We speculate that defective olfaction in PCD is primary in nature.
Shoemark A, Moya E, Hirst RA, et al., 2018, High prevalence of CCDC103 p.His154Pro mutation causing primary ciliary dyskinesia disrupts protein oligomerisation and is associated with normal diagnostic investigations, THORAX, Vol: 73, Pages: 157-166, ISSN: 0040-6376
Simmonds NJ, Bush A, 2018, The Man in the Paper Mask: One (Mask) for All and All for . . . Cystic Fibrosis?, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 197, Pages: 281-283, ISSN: 1073-449X
Thursfield RM, Naderi K, Leaver N, et al., 2018, Children with cystic fibrosis demonstrate no respiratory immunological, infective or physiological, consequences of vitamin D deficiency., J Cyst Fibros
BACKGROUND: Vitamin D has health benefits in many respiratory diseases but the evidence in CF is unclear. Induction of the antimicrobial peptides cathelicidin (LL37) and human-beta-defensin-2 (HBD-2) may be the mechanism of any benefit. We hypothesised that antimicrobial peptide levels would be decreased, and airway infection and inflammation greater, in CF children with vitamin D deficiency. The objective of the study was to explore relationships between vitamin D, LL37 and HBD-2, and airway infection, inflammation and physiology in children with CF. METHODS: Bronchoalveolar lavage (BALF) and blood were obtained from children undergoing fibreoptic bronchoscopy. Serum vitamin D, BALF HBD-2 and LL37, cultured bacteria and inflammatory markers were measured. Clinical parameters were recorded. RESULTS: 113 patients with CF, 23 with non-CF chronic suppurative lung disease (CSLD) and 6 healthy controls were included. We found no relationship between serum vitamin D and BALF HBD-2 or LL-37. There were no differences in infective or inflammatory markers between vitamin D sufficient and deficient groups. Vitamin D deficient patients (<50 nmol/L) did not have a worse FEV1 (CF: 66 (58-71)% vs. 71.5 (61-76)%, ns; non-CF CSLD: 69 (36-88)% vs. 70 (62-95)%, ns). CONCLUSIONS: In the first bronchoscopic study exploring this question, we demonstrate that vitamin D deficiency is not associated with immunological, infective or clinical markers of disease severity in patients with CF or CSLD.
Turnbull AR, Murphy R, Behrends V, et al., 2018, Impact of T2R38 Receptor Polymorphisms on Pseudomonas aeruginosa Infection in Cystic Fibrosis., Am J Respir Crit Care Med
Wright M, Manzur A, Bush A, 2018, Case of paediatric neuromuscular disease with a surprising clinical outcome: time to challenge the dogma?, Thorax
Wright MFA, Bush A, Carr SB, 2018, Hypersensitivity reactions to intravenous antibiotics in cystic fibrosis., Paediatr Respir Rev
Hypersensitivity reactions to intravenous antibiotics are common in cystic fibrosis (CF). As well as causing immediate morbidity, the need for future avoidance of the causative antibiotic can have a long-term negative impact on CF management. This paper reviews the epidemiology and clinical presentation of hypersensitivity reactions in CF patients, and using an illustrative case describes a rare but severe form of delayed drug reaction for which a high index of suspicion is required.
de Benedictis FM, Bush A, 2018, Respiratory manifestations of gastro-oesophageal reflux in children., Arch Dis Child, Vol: 103, Pages: 292-296
Gastro-oesophageal reflux disease (GORD) is a complex problem in children. Suspected respiratory manifestations of GORD, such as asthma, chronic cough and laryngitis, are commonly encountered in the paediatric practice, but continue to be entities with more questions than answers. The accuracy of diagnostic tests (ie, pH or pH-impedance monitoring, laryngoscopy, endoscopy) for patients with suspected extraoesophageal manifestations of GORD is suboptimal and therefore whether there is a causal relationship between these conditions remains largely undetermined. An empiric trial of proton pump inhibitors can help individual children with undiagnosed respiratory symptoms and suspicion of GORD, but the response to therapy is unpredictable, and in any case what may be being observed is spontaneous improvement. Furthermore, the safety of these agents has been called into question. Poor response to antireflux therapy is an important trigger to search for non-gastro-oesophageal reflux causes for patients' symptoms. Evidence for the assessment of children with suspected extraoesophageal manifestations of GORD is scanty and longitudinal studies with long-term follow-up are urgently required.
Andersson CK, Adams A, Nagakumar P, et al., 2017, Intraepithelial neutrophils in pediatric severe asthma are associated with better lung function, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 139, Pages: 1819-+, ISSN: 0091-6749
Arigliani M, Raywood E, Verger N, et al., 2017, Shortened Multiple Breath Washout Is Not Suitable for Scond Calculation in Patients with Cystic Fibrosis., PEDIATRIC PULMONOLOGY, Vol: 52, Pages: S154-S154, ISSN: 8755-6863
Artiso L, Walker S, Fleming L, et al., 2017, Sputum Eosinophil Peroxidase (EPX) Differentiates Pediatric Severe Therapy Resistant Asthma (STRA) from Difficult Asthma (DA)., PEDIATRIC PULMONOLOGY, Vol: 52, Pages: S105-S106, ISSN: 8755-6863
Belgrave D, Cassidy R, Custovic A, et al., 2017, Predictive Modelling Strategies to Understand Heterogeneous Manifestations of Asthma in Early Life, 16th IEEE International Conference on Machine Learning and Applications (ICMLA), Publisher: IEEE, Pages: 68-75
Bousquet J, Farrell J, Crooks G, et al., 2017, Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5) (vol 6, 29, 2016), CLINICAL AND TRANSLATIONAL ALLERGY, Vol: 7, ISSN: 2045-7022
Brugha R, Hall A, Bush A, 2017, It ain't necessarily so: a surprising lower airway infection, THORAX, Vol: 72, Pages: 96-97, ISSN: 0040-6376
Bush A, 2017, Markers of Severity in Difficult-To-Treat Asthma, PEDIATRIC PULMONOLOGY, Vol: 52, Pages: S36-S37, ISSN: 8755-6863
Bush A, 2017, Diffuse lung disease in children: transcending continental boundaries, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 21, Pages: 837-839, ISSN: 1027-3719
Bush A, 2017, Evidence-based approach to congenital thoracic malformations, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 102, Pages: 1095-1095, ISSN: 0003-9888
Bush A, 2017, Translating Asthma: Dissecting the Role of Metabolomics, Genomics and Personalized Medicine., Indian J Pediatr
The management of asthma has largely stagnated over the last 25 years, but we are at the dawning of a new age wherein -omics technology can help us manage the disease objectively and rationally. Even in this new scientific age, getting the basics of asthma management right remains essential. The new technologies which can be applied to multiple biological samples include genomics (study of the genome), transcriptomics (gene transcription), lipidomics, proteomics and metabolomics (lipids, proteins and metabolites, respectively) and breathomics, using exhaled breath as a source of biomarkers, which is of particular interest in view of its non-invasive nature in pediatrics. Important applications will include the diagnosis of airways disease, including its components; the pathways driving airway pathology; monitoring the response to treatment; and measuring future risk (asthma attacks, poor lung growth trajectory). With the advent of a wide range of novel biologicals to treat asthma, -omics technology to personalize therapy will be especially important. The U-BIOPRED (Europe) and SARP (USA) groups have been most active in this field, especially using bronchoscopically obtained samples to perform cluster analyses to define new asthma endotypes. However, stability over time and consistency between investigators is imperfect. This is perhaps unsurprising; results of biomarker studies in asthma will be a composite of the underlying disease, the (variable) effects of adverse drivers such as allergen exposure and pollution, the effects of treatment, and the effects of adherence or otherwise to treatment. Ultimately, the aim should be an exhaled breath based tool with a rapid result that can be used as a routine in the clinic. However, at the moment, there are as yet no clinical applications in children of -omics technology.
Bush A, 2017, Persistent Bacterial Bronchitis: time to venture beyond the Umbrella, FRONTIERS IN PEDIATRICS, Vol: 5, ISSN: 2296-2360
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