Publications
1244 results found
Minasian C, Wallis C, Metcalfe C, et al., 2008, Bronchial Provocation Testing With Dry Powder Mannitol in Children With Cystic Fibrosis, PEDIATRIC PULMONOLOGY, Vol: 43, Pages: 1078-1084, ISSN: 8755-6863
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- Citations: 15
Brand PLP, Baraldi E, Bisgaard H, et al., 2008, Definition, assessment and treatment of wheezing disorders in preschool children:: an evidence-based approach, EUROPEAN RESPIRATORY JOURNAL, Vol: 32, Pages: 1096-1110, ISSN: 0903-1936
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- Citations: 600
Tran-Dang M, Bush A, Sheppard M, et al., 2008, Evaluation of a novel classification scheme for diffuse lung disease in childhood, 27th International Congress of the International-Academy-of-Pathology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 364-365, ISSN: 0309-0167
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- Citations: 1
Sly PD, Boner AL, Bjorksten B, et al., 2008, Early identification of atopy in the prediction of persistent asthma in children, LANCET, Vol: 372, Pages: 1100-1106, ISSN: 0140-6736
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- Citations: 269
Bush A, Hedlin G, Carlsen K-H, et al., 2008, Severe childhood asthma: a common international approach?, LANCET, Vol: 372, Pages: 1019-1021, ISSN: 0140-6736
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- Citations: 71
Saglani S, Bush A, 2008, Asthma, atopy, and airway inflammation - What does it mean in practice?, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 178, Pages: 437-438, ISSN: 1073-449X
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- Citations: 6
MacGregor G, Gray RD, Hilliard TN, et al., 2008, Biomarkers for cystic fibrosis lung disease: Application of SELDI-TOF mass spectrometry to BAL fluid, JOURNAL OF CYSTIC FIBROSIS, Vol: 7, Pages: 352-358, ISSN: 1569-1993
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- Citations: 35
Bush A, Price D, 2008, Pro-con debate: Inhaled corticosteroids should not be prescribed in primary care to children under two years of age - the case for., Prim Care Respir J, Vol: 17, Pages: 176-180, ISSN: 1471-4418
Inhaled corticosteroids (ICS) are effective treatment for older children and adults with asthma. Pathological studies have established that eosinophilic inflammation is important especially in mild to moderate asthma, thus providing a rationale for ICS treatment. However, we have wrongly concluded in the past that early and aggressive treatment of asthma is needed to prevent irreversible scarring and airflow obstruction. We have increasing evidence from all age groups that there are non-eosinophilic asthma phenotypes, that remodelling is independent of inflammation, and that steroids do not prevent children developing progressive airflow obstruction. Asthma treatments that are valuable in adults may not be effective in children, and safe prescribing requires paediatric clinical trials. In young preschool children, the evidence for any eosinophilic airway inflammation is scant, the symptomatic benefit of inhaled steroids is meagre, and there is clear evidence that ICS do not modify the natural history. There is also the potential for steroids to interfere with the developing lung. Thus, we believe that ICS should not be prescribed in primary care for children under two years of age, and that if these children are thought to need more than intermittent therapy with beta-agonists or possibly leukotriene antagonists, specialist referral is mandatory.
Kozlowska WJ, Bush A, Wade A, et al., 2008, Lung function from infancy to the preschool years after clinical diagnosis of cystic fibrosis, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 178, Pages: 42-49, ISSN: 1073-449X
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- Citations: 119
Narang I, Rosenthal M, Cremonesini D, et al., 2008, Longitudinal evaluation of airway function 21 years after preterm birth, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 178, Pages: 74-80, ISSN: 1073-449X
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- Citations: 119
Salerno T, Cutrera R, Bottero S, et al., 2008, 'Iatrogenic' tooth inhalation., Pediatr Pulmonol, Vol: 43
Hilliard TN, Zhu J, Farley R, et al., 2008, Nasal abnormalities in cystic fibrosis mice independent of infection and inflammation, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 39, Pages: 19-25, ISSN: 1044-1549
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- Citations: 12
Mackerness KJ, Jenkins GR, Bush A, et al., 2008, Characterisation of the range of neutrophil stimulating mediators in cystic fibrosis sputum, THORAX, Vol: 63, Pages: 614-620, ISSN: 0040-6376
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- Citations: 19
Bush A, Hogg J, Chitty LS, 2008, Cystic lung lesions - prenatal diagnosis and management, PRENATAL DIAGNOSIS, Vol: 28, Pages: 604-611, ISSN: 0197-3851
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- Citations: 24
Bush A, Eber E, 2008, The value of FeNO measurement in asthma management: the motion for - Yes, it's NO or, the wrong end of the Stick!, PAEDIATRIC RESPIRATORY REVIEWS, Vol: 9, Pages: 127-131, ISSN: 1526-0542
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- Citations: 19
Bush A, 2008, Genes in their environment: how can we read the riddles?, JORNAL DE PEDIATRIA, Vol: 84, Pages: 185-188, ISSN: 0021-7557
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- Citations: 4
Regamey N, Ochs M, Hilliard TN, et al., 2008, Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 177, Pages: 837-843, ISSN: 1073-449X
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- Citations: 128
Bush A, 2008, Update in pediatric lung disease 2007, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 177, Pages: 686-695, ISSN: 1073-449X
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- Citations: 8
Bush A, 2008, How early do airway inflammation and remodeling occur?, Allergol Int, Vol: 57, Pages: 11-19, ISSN: 1323-8930
Eosinophilic airway inflammation and structural airway changes are present in school age asthmatics. When these changes occur, and their relationship, are controversial. Some structural airway changes, up-regulation of collagens 1 and 111, and increased distance between alveolar tethering points, may be antenatal, and independent of inflammation. We have established that there is no eosinophilic inflammation or reticular basement membrane thickening in wheezing infants median age one year; but by age three years, both are present. This accords with cohort studies, showing that children who become persistent wheezers have a drop in lung function in the pre-school years. Thereafter, lung function tracks into middle age, so the preschool years represent window during which an intervention might have long term benefit. Supportive are measurements in blood and bronchoalveolar lavage fluid, implicating the neutrophil as the key inflammatory cell in early wheeze. Models of the pathophysiology of asthma include (1) that eosinophilic inflammation is the primary event, and leads to remodelling as a secondary event, which itself results in progressive airflow obstruction (the least likely model); (2) eosinophilic inflammation is the primary event, but remodelling is protective, preventing worsening AHR. It should be noted that these first two are not mutually exclusive; rbm thickening may be protective, but other components of remodeling, for example increased ASM, may have adverse effects; (3) eosinophilic inflammation and airway remodelling are parallel processes, driven by some underlying 'asthma factor'; and (4) the primary abnormality is not airway inflammation, but some form of disordered airway repair.
Wilson NM, Bush A, 2008, β<sub>2</sub>-Adrenoceptor polymorphisms and asthma phenotypes:: interactions with passive smoking, EUROPEAN RESPIRATORY JOURNAL, Vol: 31, Pages: 479-480, ISSN: 0903-1936
Bush A, 2008, COPD: A Pediatric Disease, COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Vol: 5, Pages: 53-67, ISSN: 1541-2555
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- Citations: 84
Erin EM, Jenkins GR, Kong OM, et al., 2008, Optimized dialysis and protease inhibition of sputum dithiothreitol supernatants (Retracted article. See vol. 183, pg. 418, 2011), AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 177, Pages: 132-141, ISSN: 1073-449X
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- Citations: 21
Regamey N, Hilliard TN, Saglani S, et al., 2008, Endobronchial biopsy in childhood, CHEST, Vol: 133, Pages: 312-312, ISSN: 0012-3692
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- Citations: 3
Goldstraw P, Bush A, Nicholson AG, et al., 2008, CT and histopathological correlation of congenital cystic pulmonary lesions: a common pathogenesis?, Clinical …
Brown S, Padley S, Bush A, et al., 2008, Mycoplasma pneumonia and pulmonary embolism in a child due to acquired prothrombotic factors, Pediatric …
Bush A, 2008, Childhood influences on later lung health., Chron Respir Dis, Vol: 5, Pages: 223-224, ISSN: 1479-9723
Davies JC, Alton EWFW, Bush A, 2007, Cystic fibrosis, BMJ-BRITISH MEDICAL JOURNAL, Vol: 335, Pages: 1255-1259, ISSN: 1756-1833
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- Citations: 228
Nicholson AG, Bush A, 2007, Classification of diffuse lung disease in infants - The reality of groups, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 176, Pages: 1060-1061, ISSN: 1073-449X
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- Citations: 8
Fleming L, Bracken M, Hall P, et al., 2007, Characterisation of children with difficult to treat asthma, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A38-A38, ISSN: 0040-6376
Bush A, Chodhari R, Collins N, et al., 2007, Primary ciliary dyskinesia: current state of the art, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 92, Pages: 1136-1140, ISSN: 0003-9888
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- Citations: 240
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