Publications
1244 results found
Hogg C, Bush A, 2021, Pro-Con Debate CON: Primary Ciliary Dyskinesia diagnosis: Genes are all you need!, PAEDIATRIC RESPIRATORY REVIEWS, Vol: 37, Pages: 34-36, ISSN: 1526-0542
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- Citations: 3
Bush A, Levy M, Fleming L, 2021, Steroid-filled rant: or another fashion accessory?, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 106, Pages: 211-+, ISSN: 0003-9888
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- Citations: 2
Galaz Souza N, Bush A, Tan H-L, 2021, Exploratory study of the effectiveness of nebulised saline in children with neurodisability., Eur Respir J, Vol: 57
The prescription of nebulised saline in children and young people with neurodisability was associated with improved respiratory outcomes and was favourably received by patients and their caregivers https://bit.ly/3mSyzag
Gidaris D, Stabouli S, Bush A, 2021, Beware the inhaled steroids or corticophobia?, SWISS MEDICAL WEEKLY, Vol: 151, ISSN: 1424-7860
Jamalzadeh A, Makhecha S, Irving S, et al., 2021, FROM HOSPITAL TO HOME: VIRTUALLY OBSERVED ADMINISTRATION OF BIOLOGICS IN CHILDREN WITH SEVERE ASTHMA DURING COVID-19, Publisher: BMJ PUBLISHING GROUP, Pages: A138-A139, ISSN: 0040-6376
Lynch A, Nicholson A, Bush A, et al., 2021, Pattern recognition in acute wheeze, ARCHIVES OF DISEASE IN CHILDHOOD-EDUCATION AND PRACTICE EDITION, Vol: 106, Pages: 41-43, ISSN: 1743-0585
Bush A, Mayell S, Pabary R, 2021, Pulmonary lymphangiectasia, ERS Monograph, Vol: 2021, Pages: 197-212, ISSN: 2312-508X
Pulmonary lymphangiectasia is a rare disorder that causes accumulation of lymph within the lungs and accounts for less than 1% of antenatal and perinatal deaths. Primary pulmonary lymphangiectasia results from abnormal lymphatic development and secondary pulmonary lymphangiectasia is due to obstruction of normal lymphatic flow. Lymphatic development is complex and controlled by multiple genes and can be impacted upon by numerous chromosomal disorders as well as environmental changes, such as infection. Presentations outside the neonatal period are also well recognised. Management requires extensive antenatal/post-natal investigations to find an underlying cause and supportive care is the mainstay of treatment; there is currently no known cure, although a variety of treatments are suggested anecdotally.
Holguin F, Cardet JC, Chung KF, et al., 2021, Management of severe asthma: A European Respiratory Society/American Thoracic Society guideline, Pulmonologiya, Vol: 31, Pages: 272-295, ISSN: 0869-0189
This document provides clinical recommendations for the management of severe asthma. Comprehensive evidence syntheses, including metaanalyses, were performed to summarise all available evidence relevant to the European Respiratory Society/American Thoracic Society Task Force’s questions. The evidence was appraised using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach and the results were summarised in evidence profiles. The evidence syntheses were discussed and recommendations formulated by a multidisciplinary Task Force of asthma experts, who made specific recommendations on six specific questions. After considering the balance of desirable and undesirable consequences, quality of evidence, feasibility, and acceptability of various interventions, the Task Force made the following recommendations: • suggest using anti-interleukin (IL)-5 and anti-IL-5 receptor α for severe uncontrolled adult eosinophilic asthma phenotypes; • suggest using a blood eosinophil cut-point ≥150 μL−1 to guide anti-IL-5 initiation in adult patients with severe asthma; • suggest considering specific eosinophil (≥260 μL−1) and exhaled nitric oxide fraction (≥19.5 ppb) cut-offs to identify adolescents or adults with the greatest likelihood of response to anti-IgE therapy; • suggest using inhaled tiotropium for adolescents and adults with severe uncontrolled asthma despite Global Initiative for Asthma (GINA) step 4 – 5 or National Asthma Education and Prevention Program (NAEPP) step 5 therapies; • suggest a trial of chronic macrolide therapy to reduce asthma exacerbations in persistently symptomatic or uncontrolled patients on GINA step 5 or NAEPP step 5 therapies, irrespective of asthma phenotype; • suggest using anti-IL-4/13 for adult patients with severe eosinophilic asthma and for those with severe corticosteroid-dependent asthma regardless of blood eosinophil levels. These reco
Bush A, Ferkol T, Valiulis A, et al., 2021, Unfriendly Fire: How the Tobacco Industry is Destroying the Future of Our Children., Acta Med Litu, Vol: 28, Pages: 6-18, ISSN: 1392-0138
Tobacco has long been known to be one of the greatest causes of morbidity and mortality in the adults, but the effects on the foetus and young children, which are lifelong, have been less well appreciated. Developing from this are electronic nicotine delivery systems or vapes, promulgated as being less harmful than tobacco. Nicotine itself is toxic to the foetus, with permanent effects on lung structure and function. Most vapes contain nicotine, but they also contain many other compounds which are inhaled and for which there are no toxicity studies. They also contain known toxic substances, whose use is banned by European Union legislation. Accelerating numbers of young people are vaping, and this does not reflect an exchange of vapes for cigarettes. The acute toxicity of e-cigarettes is greater than that of tobacco, and includes acute lung injury, pulmonary haemorrhage and eosinophilic and lipoid pneumonia. Given the worse acute toxicity, it should be impossible to be complacent about medium and long term effects of vaping. Laboratory studies have demonstrated changes in lung proteomics and the innate immune system with vaping, some but not all of which overlap with tobacco. It would be wrong to consider vapes as a weaker form of tobacco, they have their own toxicity. Children and young people are being targeted by the vaping industry (which is largely the same as the tobacco industry), including on-line, and unless an efficient legislative program is put in place, a whole new generation of nicotine addicts will result.
Bousquet J, Cristol J-P, Czarlewski W, et al., 2020, Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies, Clinical and Translational Allergy, Vol: 10, Pages: 1-18, ISSN: 2045-7022
There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
Bousquet J, Anto JM, Iaccarino G, et al., 2020, Is diet partly responsible for differences in COVID-19 death rates between and within countries?, Clinical and Translational Allergy, Vol: 10, ISSN: 2045-7022
Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be significant are the dietary habits. It seems that some foods largely used in these countries may reduce angiotensin-converting enzyme activity or are anti-oxidants. Among the many possible areas of research, it might be important to understand diet and angiotensin-converting enzyme-2 (ACE2) levels in populations with different COVID-19 death rates since dietary interventions may be of great benefit.
Perikleous E, Tsalkidis A, Bush A, et al., 2020, Coronavirus global pandemic: An overview of current findings among pediatric patients, PEDIATRIC PULMONOLOGY, Vol: 55, Pages: 3252-3267, ISSN: 8755-6863
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- Citations: 20
Andersson CK, Iwasaki J, Cook J, et al., 2020, Impaired airway epithelial cell wound-healing capacity is associated with airway remodelling following RSV infection in severe preschool wheeze, ALLERGY, Vol: 75, Pages: 3195-3207, ISSN: 0105-4538
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- Citations: 12
Gorlanova O, Tischhauser E, Adcock IM, et al., 2020, Discordant use of short-acting beta(2) agonists in children and adults with severe, uncontrolled asthma from the U-BIOPRED cohort, Pediatric Pulmonology, Pages: 1-3, ISSN: 1099-0496
Davies G, Thia LP, Stocks J, et al., 2020, Minimal change in structural, functional and inflammatory markers of lung disease in newborn screened infants with cystic fibrosis at one year, JOURNAL OF CYSTIC FIBROSIS, Vol: 19, Pages: 896-901, ISSN: 1569-1993
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- Citations: 15
Nair N, Hurley M, Gates S, et al., 2020, Life-threatening hypersensitivity pneumonitis secondary to e-cigarettes, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 105, Pages: 1114-1116, ISSN: 0003-9888
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- Citations: 21
Bhatt JM, Ramphul M, Bush A, 2020, An update on controversies in e-cigarettes, PAEDIATRIC RESPIRATORY REVIEWS, Vol: 36, Pages: 75-86, ISSN: 1526-0542
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- Citations: 26
Bush A, Gilbert C, Gregory J, et al., 2020, Interstitial lung disease in infancy, EARLY HUMAN DEVELOPMENT, Vol: 150, ISSN: 0378-3782
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- Citations: 9
Woodhull S, Bush A, Tang AL, et al., 2020, Massive paediatric pulmonary haemorrhage in Dieulafoy's disease: Roles of CT angiography, embolisation and bronchoscopy., Paediatr Respir Rev, Vol: 36, Pages: 100-105
Acute, major pulmonary haemorrhage in children, is rare, may be life-threatening and at times presents atypically. Dieulafoy's disease of the bronchus presenting with recurrent or massive hemoptysis was first described in adults. Prior to reviewing the literature, we report an illustrative case of bronchial Dieulafoy's disease (BDD) in a child presenting unusually with massive apparent hematemesis. The source of bleeding is a bronchial artery that fails to taper as it terminates within the bronchial submucosa. A high index of suspicion is required to identify such lesions via radiological imaging and the role of bronchial artery embolisation is highlighted with video images of angiography included.
Gupta A, Bush A, Nagakumar P, 2020, Asthma in children during the COVID-19 pandemic: lessons from lockdown and future directions for management, LANCET RESPIRATORY MEDICINE, Vol: 8, Pages: 1070-1071, ISSN: 2213-2600
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- Citations: 38
Abdel-Aziz MI, Brinkman P, Vijverberg SJH, et al., 2020, eNose breath prints as a surrogate biomarker for classifying patients with asthma by atopy, Journal of Allergy and Clinical Immunology, Vol: 146, Pages: 1045-1055, ISSN: 0091-6749
BACKGROUND: Electronic noses (eNoses) are emerging point-of-care tools that may help in the subphenotyping of chronic respiratory diseases such as asthma. OBJECTIVE: We aimed to investigate whether eNoses can classify atopy in pediatric and adult patients with asthma. METHODS: Participants with asthma and/or wheezing from 4 independent cohorts were included; BreathCloud participants (n = 429), Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes adults (n = 96), Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes pediatric participants (n = 100), and Pharmacogenetics of Asthma Medication in Children: Medication with Anti-Inflammatory Effects 2 participants (n = 30). Atopy was defined as a positive skin prick test result (≥3 mm) and/or a positive specific IgE level (≥0.35 kU/L) for common allergens. Exhaled breath profiles were measured by using either an integrated eNose platform or the SpiroNose. Data were divided into 2 training and 2 validation sets according to the technology used. Supervised data analysis involved the use of 3 different machine learning algorithms to classify patients with atopic versus nonatopic asthma with reporting of areas under the receiver operating characteristic curves as a measure of model performance. In addition, an unsupervised approach was performed by using a bayesian network to reveal data-driven relationships between eNose volatile organic compound profiles and asthma characteristics. RESULTS: Breath profiles of 655 participants (n = 601 adults and school-aged children with asthma and 54 preschool children with wheezing [68.2% of whom were atopic]) were included in this study. Machine learning models utilizing volatile organic compound profiles discriminated between atopic and nonatopic participants with areas under the receiver operating characteristic curves of at least 0.84 and 0.72 in the training and validation sets, respectively. The unsupervised approach revealed t
Bousquet J, Anto JM, Iaccarino G, et al., 2020, Is diet partly responsible for differences in COVID-19 death rates between and within countries? (vol 10, 16, 2020), Clinical and Translational Allergy, Vol: 10, Pages: 1-3, ISSN: 2045-7022
Roberts G, Fontanella S, Selby A, et al., 2020, Connectivity patterns between multiple allergen specific IgE antibodies and their association with severe asthma, Journal of Allergy and Clinical Immunology, Vol: 146, Pages: 821-830, ISSN: 0091-6749
BACKGROUND: Allergic sensitization is associated with severe asthma, but assessment of sensitization is not recommended by most guidelines. OBJECTIVE: We hypothesized that patterns of IgE responses to multiple allergenic proteins differ between sensitized participants with mild/moderate and severe asthma. METHODS: IgE to 112 allergenic molecules (components, c-sIgE) was measured using multiplex array among 509 adults and 140 school-age and 131 preschool children with asthma/wheeze from the Unbiased BIOmarkers for the PREDiction of respiratory diseases outcomes cohort, of whom 595 had severe disease. We applied clustering methods to identify co-occurrence patterns of components (component clusters) and patterns of sensitization among participants (sensitization clusters). Network analysis techniques explored the connectivity structure of c-sIgE, and differential network analysis looked for differences in c-sIgE interactions between severe and mild/moderate asthma. RESULTS: Four sensitization clusters were identified, but with no difference between disease severity groups. Similarly, component clusters were not associated with asthma severity. None of the c-sIgE were identified as associates of severe asthma. The key difference between school children and adults with mild/moderate compared with those with severe asthma was in the network of connections between c-sIgE. Participants with severe asthma had higher connectivity among components, but these connections were weaker. The mild/moderate network had fewer connections, but the connections were stronger. Connectivity between components with no structural homology tended to co-occur among participants with severe asthma. Results were independent from the different sample sizes of mild/moderate and severe groups. CONCLUSIONS: The patterns of interactions between IgE to multiple allergenic proteins are predictors of asthma severity among school children and adults with allergic asthma.
Bush A, Saglani S, 2020, Medical algorithm: diagnosis and treatment of preschool asthma, Allergy, Vol: 75, Pages: 2711-2712, ISSN: 0105-4538
Davies G, Stanojevic S, Raywood E, et al., 2020, An observational study of the lung clearance index throughout childhood in cystic fibrosis: early years matter, EUROPEAN RESPIRATORY JOURNAL, Vol: 56, ISSN: 0903-1936
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- Citations: 18
Makrinioti H, Watson M, Bush A, et al., 2020, COVID-19 and preschool wheeze care: lessons learned., Lancet Respir Med, Vol: 8, Pages: 957-959
Bush A, Saglani S, 2020, Preschool wheeze: Challenges and research prospects reply to: Dr Jartti and Colleagues; in response to our manuscript entitled: Medical algorithm: Diagnosis and treatment of preschool asthma, ALLERGY, Vol: 75, Pages: 2718-2718, ISSN: 0105-4538
Edmondson C, Westrupp N, Wallenburg J, et al., 2020, MONITORING LUNG FUNCTION OF YOUNG PEOPLE WITH CF AT HOME: IS IT RELIABLE? RESULTS FROM THE CLIMB-CF STUDY, Publisher: WILEY, Pages: S290-S290, ISSN: 8755-6863
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- Citations: 1
Edmondson C, Westrupp N, Wallenburg J, et al., 2020, WHAT IS FEASIBLE WHEN IT COMES TO MONITORING YOUNG PEOPLE WITH CYSTIC FIBROSIS AT HOME? THE RESULTS OF THE CLIMB-CF STUDY, Publisher: WILEY, Pages: S297-S297, ISSN: 8755-6863
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- Citations: 2
Ring AM, Carlens J, Bush A, et al., 2020, Pulmonary function testing in children's interstitial lung disease, EUROPEAN RESPIRATORY REVIEW, Vol: 29, ISSN: 0905-9180
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- Citations: 8
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