She joined Imperial College in 2009 as a Marie Curie International Incoming Fellow in the laboratory of Professor Gad Frankel. This followed a postdoctoral position in the laboratory of Professor Trevor Lithgow at Monash University and a PhD at the University of Melbourne with Professor Richard Strugnell.
Dr Clements’ interests are in bacterial pathogenesis and the underlying molecular mechanisms. Her work therefore encompasses aspects of cellular microbiology, molecular microbiology, clinical microbiology, biochemistry, and many more disciplines. Her group currently works on a number of bacterial pathogens including Shigella sp and Klebsiella pneumoniae.
Shigella species are responsible for bacillary dysentery or shigellosis, a disease estimated to cause nearly 1 million deaths per year. Two Shigella species (flexneri and sonnei) are responsible for the majority of the disease burden with flexneri infection causing the majority of infections in low income countries and sonnei in high income countries. The lab is interested in comparing the molecular mechanisms used by both pathogens in order to understand the different epidemiology observed.
Klebsiella pneumoniae (Kp) are opportunistic pathogens that are particularly adept at acquiring antimicrobial resistance (AMR). High risk global multi-resistant genetic lineages are responsible for the increased prevalence of Kp infections and the lab are interested in understanding the features of these lineages that result in increased virulence.
Selected recent publications
et al., 2021, The type III secretion system effector EspO of enterohaemorrhagic Escherichia coli inhibits apoptosis through an interaction with HAX-1, Cellular Microbiology, Vol:23, ISSN:1462-5814
et al., 2020, Mammalian lectin arrays for screening host–microbe interactions, Journal of Biological Chemistry, Vol:295, ISSN:0021-9258, Pages:4541-4555
et al., 2020, Vying for the control of inflammasomes: the cytosolic frontier of enteric bacterial pathogen - host interactions, Cellular Microbiology, Vol:22, ISSN:1462-5814, Pages:1-19
et al., 2019, Shigella sonnei O-Antigen Inhibits Internalization, Vacuole Escape, and Inflammasome Activation, Mbio, Vol:10, ISSN:2150-7511, Pages:1-14
et al., 2019, Shigella sonnei infection of zebrafish reveals that O-antigen mediates neutrophil tolerance and dysentery incidence, Plos Pathogens, Vol:15, ISSN:1553-7366, Pages:1-26