Imperial College London

Dr Abigail Clements

Faculty of Natural SciencesDepartment of Life Sciences

Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7681a.clements

 
 
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Location

 

Lvl 1Flowers buildingSouth Kensington Campus

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Summary

 

Summary

Shigella species are responsible for bacillary dysentery or shigellosis, a disease estimated to cause nearly 1 million deaths per year. Shigella species are closely related to the pathogenic E. coli, with Shigella and enteroinvasive E. coli being clinically indistinguishable. These pathogens utilise a common infection strategy whereby bacterial effector proteins are delivered directly into the host cell via a type 3 secretion system (T3SS), a strategy also shared by many other pathogenic bacteria (e.g. Salmonella, Yersinia and Vibrio spp).

Research in my laboratory currently focuses on structure/function studies of effector proteins that are common between the extracellular pathogenic E. coli (enteropathogenic and enterohaemorrhagic E. coli) and the intracellular enteroinvasive E. coli and Shigella species. The signalling pathways targeted by effectors that are shared by intracellular and extracellular pathogens represent fundamental processes required for infection such as subversion of cellular trafficking and regulation of apoptosis.

Selected recent publications

Publications

Journals

Berger CN, Crepin VF, Roumeliotis TI, et al., 2017, Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In Vivo., Cell Metab

Furniss RCD, Clements A, 2017, Regulation of the Locus of Enterocyte Effacement in Attaching and Effacing Pathogens., J Bacteriol

Furniss RCD, Slater S, Frankel G, et al., 2016, Enterohaemorrhagic E. coli modulates an ARF6:Rab35 signaling axis to prevent recycling endosome maturation during infection, Journal of Molecular Biology, Vol:428, ISSN:0022-2836, Pages:3399-3407

Larrouy-Maumus G, Clements A, Filloux A, et al., 2016, Direct detection of lipid A on intact Gram-negative bacteria by MALDI-TOF mass spectrometry, Journal of Microbiological Methods, Vol:120, ISSN:0167-7012, Pages:68-71

Mavridou DAI, Gonzalez D, Clements A, et al., 2016, The pUltra plasmid series: A robust and flexible tool for fluorescent labeling of Enterobacteria, Plasmid, Vol:87-88, ISSN:0147-619X, Pages:65-71

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