Imperial College London

Dr Abigail Clements

Faculty of Natural SciencesDepartment of Life Sciences




+44 (0)20 7594 7681a.clements




Lvl 1Flowers buildingSouth Kensington Campus





Shigella species are responsible for bacillary dysentery or shigellosis, a disease estimated to cause nearly 1 million deaths per year. Shigella species are closely related to the pathogenic E. coli, with Shigella and enteroinvasive E. coli being clinically indistinguishable. These pathogens utilise a common infection strategy whereby bacterial effector proteins are delivered directly into the host cell via a type 3 secretion system (T3SS), a strategy also shared by many other pathogenic bacteria (e.g. Salmonella, Yersinia and Vibrio spp).

Research in my laboratory currently focuses on structure/function studies of effector proteins that are common between the extracellular pathogenic E. coli (enteropathogenic and enterohaemorrhagic E. coli) and the intracellular enteroinvasive E. coli and Shigella species. The signalling pathways targeted by effectors that are shared by intracellular and extracellular pathogens represent fundamental processes required for infection such as subversion of cellular trafficking and regulation of apoptosis.

Selected recent publications



Watson J, Jenkins C, Clements A, 2018, Shigella sonnei Does Not Use Amoebae as Protective Hosts, Applied and Environmental Microbiology, Vol:84, ISSN:0099-2240

Furniss RCD, Clements A, 2018, Regulation of the Locus of Enterocyte Effacement in Attaching and Effacing Pathogens, Journal of Bacteriology, Vol:200, ISSN:0021-9193

Berger CN, Crepin VF, Roumeliotis TI, et al., 2017, Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In Vivo, Cell Metabolism, Vol:26, ISSN:1550-4131, Pages:738-+

Mavridou DAI, Gonzalez D, Clements A, et al., 2016, The pUltra plasmid series: A robust and flexible tool for fluorescent labeling of Enterobacteria, Plasmid, Vol:87-88, ISSN:0147-619X, Pages:65-71

Furniss RCD, Slater S, Frankel G, et al., 2016, Enterohaemorrhagic E. coli modulates an ARF6:Rab35 signaling axis to prevent recycling endosome maturation during infection, Journal of Molecular Biology, Vol:428, ISSN:0022-2836, Pages:3399-3407

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