Imperial College London

Dr Abigail Clements

Faculty of Natural SciencesDepartment of Life Sciences

Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7681a.clements

 
 
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Location

 

Lvl 1Flowers buildingSouth Kensington Campus

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Summary

 

Summary

Shigella species are responsible for bacillary dysentery or shigellosis, a disease estimated to cause nearly 1 million deaths per year. Shigella species are closely related to the pathogenic E. coli, with Shigella and enteroinvasive E. coli being clinically indistinguishable. These pathogens utilise a common infection strategy whereby bacterial effector proteins are delivered directly into the host cell via a type 3 secretion system (T3SS), a strategy also shared by many other pathogenic bacteria (e.g. Salmonella, Yersinia and Vibrio spp).

Research in my laboratory currently focuses on structure/function studies of effector proteins that are common between the extracellular pathogenic E. coli (enteropathogenic and enterohaemorrhagic E. coli) and the intracellular enteroinvasive E. coli and Shigella species. The signalling pathways targeted by effectors that are shared by intracellular and extracellular pathogens represent fundamental processes required for infection such as subversion of cellular trafficking and regulation of apoptosis.

Selected recent publications

Publications

Journals

Watson J, Sanchez-garrido J, Goddard P, et al., Shigella sonnei O-antigen inhibits internalisation, vacuole escape and inflammasome activation, Mbio, ISSN:2150-7511

Wong JLC, Romano M, Kerry L, et al., OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo, Nature Communications, ISSN:2041-1723

Torraca V, Kaforou M, Watson J, et al., 2019, Shigella sonnei infection of zebrafish reveals that O-antigen mediates neutrophil tolerance and dysentery incidence

Furniss RCD, Low WW, Mavridou DAI, et al., 2018, Plasma membrane profiling during enterohemorrhagic E. coli infection reveals that the metalloprotease StcE cleaves CD55 from host epithelial surfaces, Journal of Biological Chemistry, Vol:293, ISSN:0021-9258, Pages:17188-17199

Torres VVL, Heinz E, Stubenrauch CJ, et al., 2018, An investigation into the Omp85 protein BamK in hypervirulent Klebsiella pneumoniae, and its role in outer membrane biogenesis, Molecular Microbiology, Vol:109, ISSN:0950-382X, Pages:584-599

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