Imperial College London

Dr Abigail Clements

Faculty of Natural SciencesDepartment of Life Sciences

Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7681a.clements

 
 
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Location

 

Lvl 1Flowers buildingSouth Kensington Campus

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Summary

 

Summary

Shigella species are responsible for bacillary dysentery or shigellosis, a disease estimated to cause nearly 1 million deaths per year. Shigella species are closely related to the pathogenic E. coli, with Shigella and enteroinvasive E. coli being clinically indistinguishable. These pathogens utilise a common infection strategy whereby bacterial effector proteins are delivered directly into the host cell via a type 3 secretion system (T3SS), a strategy also shared by many other pathogenic bacteria (e.g. Salmonella, Yersinia and Vibrio spp).

Research in my laboratory currently focuses on structure/function studies of effector proteins that are common between the extracellular pathogenic E. coli (enteropathogenic and enterohaemorrhagic E. coli) and the intracellular enteroinvasive E. coli and Shigella species. The signalling pathways targeted by effectors that are shared by intracellular and extracellular pathogens represent fundamental processes required for infection such as subversion of cellular trafficking and regulation of apoptosis.

Selected recent publications

Publications

Journals

Drickamer K, 2020, Mammalian lectin arrays for screening host–microbe interactions, Journal of Biological Chemistry, ISSN:0021-9258

Sanchez Garrido J, Slater SL, Clements A, et al., Vying for the control of inflammasomes: the cytosolic frontier of enteric bacterial pathogen - host interactions, Cellular Microbiology, ISSN:1462-5814

Watson J, Sanchez-garrido J, Goddard P, et al., Shigella sonnei O-Antigen Inhibits Internalization, Vacuole Escape, and Inflammasome Activation, Mbio, Vol:10, ISSN:2150-7511

Torraca V, Kaforou M, Watson J, et al., 2019, Shigella sonnei infection of zebrafish reveals that O-antigen mediates neutrophil tolerance and dysentery incidence, Plos Pathogens, Vol:15, ISSN:1553-7366, Pages:1-26

Wong JLC, Romano M, Kerry LE, et al., 2019, OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo, Nature Communications, Vol:10, ISSN:2041-1723

More Publications