Imperial College London

Dr Abigail Clements

Faculty of Natural SciencesDepartment of Life Sciences

Lecturer
 
 
 
//

Contact

 

+44 (0)20 7594 7681a.clements

 
 
//

Location

 

Lvl 1Flowers buildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@inbook{Clements:2013:10.1016/B978-0-12-397048-0.00015-2,
author = {Clements, A and Berger, CN and Lomma, M and Frankel, G},
booktitle = {Escherichia coli: Pathotypes and Principles of Pathogenesis: Second Edition},
doi = {10.1016/B978-0-12-397048-0.00015-2},
pages = {451--497},
title = {Type 3 secretion effectors},
url = {http://dx.doi.org/10.1016/B978-0-12-397048-0.00015-2},
year = {2013}
}

RIS format (EndNote, RefMan)

TY  - CHAP
AB - © 2015 Elsevier Inc. All rights reserved. Enterohemorrhagic E. coli (EHEC), enteropathogenic E. coli (EPEC), and Shigella use a type 3 secretion system (T3SS) to inject dozens of effector proteins into the host cell. The effectors manipulate host cell processes including the host cytoskeleton, immune response, cell survival, and gut integrity. EPEC and EHEC share a large number of common effectors and some homologous effectors can be found in Shigella, however there is also considerable variability within and between pathotypes. For many effectors detailed molecular mechanisms of action have been described by identifying host interacting partners, homologous proteins, or enzymatic activities. However, understanding effector biology within the context of infection with multiple effectors, various cell populations, and host genetic differences remains a challenge.
AU - Clements,A
AU - Berger,CN
AU - Lomma,M
AU - Frankel,G
DO - 10.1016/B978-0-12-397048-0.00015-2
EP - 497
PY - 2013///
SN - 9780123970480
SP - 451
TI - Type 3 secretion effectors
T1 - Escherichia coli: Pathotypes and Principles of Pathogenesis: Second Edition
UR - http://dx.doi.org/10.1016/B978-0-12-397048-0.00015-2
ER -