Imperial College London

Dr Abigail Clements

Faculty of Natural SciencesDepartment of Life Sciences

Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7681a.clements

 
 
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Location

 

Lvl 1Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Furniss:2017:10.1128/JB.00336-17,
author = {Furniss, RCD and Clements, A},
doi = {10.1128/JB.00336-17},
journal = {J Bacteriol},
title = {Regulation of the Locus of Enterocyte Effacement in Attaching and Effacing Pathogens.},
url = {http://dx.doi.org/10.1128/JB.00336-17},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Attaching and Effacing (AE) pathogens colonise the gut mucosa using a Type Three Secretion System (T3SS) and a suite of effector proteins. The Locus of Enterocyte Effacement (LEE) is the defining genetic feature of the AE pathogens, encoding the T3SS and the core effector proteins necessary for pathogenesis. Extensive research has revealed a complex regulatory network that senses and responds to a myriad of host and microbiota-derived signals in the infected gut to control transcription of the LEE. These signals include microbiota-liberated sugars and metabolites in the gut lumen, molecular oxygen at the gut epithelium and host hormones. Recent research has revealed that AE pathogens also perceive physical signals, such as attachment to the epithelium, and that the act of effector translocation remodels gene expression in infecting bacteria. In this review we summarise our knowledge to date and present an integrated view of how chemical, geographical and physical cues regulate the virulence program of AE pathogens during infection.
AU - Furniss,RCD
AU - Clements,A
DO - 10.1128/JB.00336-17
PY - 2017///
TI - Regulation of the Locus of Enterocyte Effacement in Attaching and Effacing Pathogens.
T2 - J Bacteriol
UR - http://dx.doi.org/10.1128/JB.00336-17
UR - https://www.ncbi.nlm.nih.gov/pubmed/28760850
UR - http://hdl.handle.net/10044/1/51948
ER -