Imperial College London


Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer



+44 (0)20 3313 3242a.comninos




Commonwealth BuildingHammersmith Campus





Dr Alexander Comninos joined Imperial College School of Medicine on Academic and Music Scholarships in 1997. He completed an intercalated BSc in Endocrinology in 2001, for which he was awarded first class honours. On completion of his medical degree, he trained in Endocrinology & Diabetes and General Internal Medicine in leading London hospitals and was awarded an NIHR Academic Clinical Fellowship to continue his research alongside his training.

He was subsequently awarded a prestigious Wellcome Trust PhD Research Fellowship in 2011, NIHR Clinical Lectureship in 2015, Wellcome Trust Institutional Lectureship in 2016 and a Biomedical Research Grant.

Dr Comninos has authored over 50 clinical and translational original research publications in Endocrinology and has presented his work in talks internationally, including at the British Endocrine Society, International Congress of Endocrinology, American Endocrine Society and European Society of Human Reproduction and Embryology Annual Conferences. He has won several international awards including three Outstanding Abstract Awards and the Best Oral Presentation in Reproductive Science from the American Endocrine Society as well as the Clinical Endocrinology Trust Prize and Leadership Development Award from the UK Society for Endocrinology.

Dr Comninos is heavily involved in clinical work as a Consultant Endocrinologist at Imperial College Healthcare NHS Trust (based at St. Mary's, Hammersmith and Charing Cross Hospitals). Alongside general endocrinology, his special interests include reproductive hormones and calcium disorders including osteoporosis and hyperparathyroidism. In addition, he continues in research and education as an Honorary Clinical Senior Lecturer and Head of Academic Tutoring at Imperial College London. He has recently been elected to the National Science Committee for the UK Society for Endocrinology..

His clinical and academic contributions were recognised by the UK Society for Endocrinology with the award of the prestigious Early Career Clinical Prize, presented to the leading Early Career Clinical Endocrinologist in the UK. He continues to publish research in notable journals including The Lancet, The Journal of Clinical Endocrinology & Metabolism, The Journal of Clinical Investigation, and Nature Reviews Endocrinology which have attracted international media attention (including BBC, Newsweek, The Times, Independent, Reuters, Televisa, New York Post), alongside his clinical Consultant Endocrine practice.



Mills EG, Yang L, Nielsen MF, et al., 2021, The Relationship Between Bone and Reproductive Hormones Beyond Estrogens and Androgens., Endocr Rev, Vol:42, Pages:691-719

Phylactou M, Abbara A, Al-Memar M, et al., 2021, Performance of plasma kisspeptin as a biomarker for miscarriage improves with gestation during the first trimester, Fertility and Sterility, Vol:116, ISSN:0015-0282, Pages:809-819

Phylactou M, Abbara A, Al-Memar M, et al., 2021, Changes in circulating kisspeptin levels during each trimester in women with antenatal complications, Journal of Clinical Endocrinology and Metabolism, ISSN:0021-972X

Phylactou M, Clarke S, Patel B, et al., 2021, Clinical and biochemical discriminants between functional hypothalamic amenorrhoea (FHA) and polycystic ovary syndrome (PCOS), Clinical Endocrinology, Vol:95, ISSN:0300-0664, Pages:239-252

Comninos A, Yang L, O’Callaghan J, et al., 2021, Kisspeptin modulates gamma-aminobutyric acid levels in the human brain, Psychoneuroendocrinology, Vol:129, ISSN:0306-4530, Pages:1-5

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