I am a Clinical Senior Lecturer at Imperial College and Honorary Consultant in Paediatric Infectious Diseases at St Mary's Hospital, Imperial College Healthcare NHS Trust. My research focuses on the interactions between hosts and pathogens which result in severe infectious diseases, particularly severe malaria. I am interested in understanding why some people get very ill and die from malaria, whilst others have a less severe illness. I have a MRC Clinician Scientist Fellowship to investigate the host-pathogen interactions which cause severe malaria.
You can read more about the challenges of severe malaria in this article: "Piecing together the puzzle of severe malaria" Published in Science Translational Medicine
My group uses a variety of approaches study malaria, ranging from clinical studies and transcriptomics, to in vitro and in vivo models. We have recently used dual RNA-sequencing to provide an integrated view of host-pathogen interactions, and you can read more about this approach here:
Other aspects of my research focus on understanding how malaria causes susceptibility to other infections, such as Non-Typhoid Salmonella bacteremia, and understanding and predicting susceptibility to infections in children with Sickle Cell Disease. Our work in Sickle Cell Disease is undertaken in collaboration with Dr Subarna Chakravorty and Dr Kirstin Lund and has been generously funded by The Rosetrees Trust.
I am currently co-convener of the Imperial College Network of Excellence in Malaria, an interdisciplinary network of more than 100 malaria researchers at Imperial College working together to eradicate malaria: http://www.imperial.ac.uk/network-of-excellence-in-malaria/
I am part of the EU-Horizon 2020 PERFORM consortium (http://www.perform2020.eu/) which seeks to develop personalized management strategies for children with febrile illness based on new diagnostic tests.
I teach on the BSc courses in Global Health and Reproductive and Developmental Medicine, and MSc courses in Immunology and Paediatrics, and short courses in Paediatric Infectious Diseases.
et al., 2018, Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria, Science Translational Medicine, Vol:10, ISSN:1946-6234
McArdle AJ, Turkova A, Cunnington AJ, 2018, When do co-infections matter?, Current Opinion in Infectious Diseases, Vol:31, ISSN:0951-7375, Pages:209-215
et al., 2018, Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions, Microbiology and Molecular Biology Reviews, Vol:82, ISSN:1092-2172
et al., 2015, Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1, Haematologica - the Hematology Journal, Vol:100, ISSN:0390-6078, Pages:1508-1516
Cunnington AJ, Walther M, Riley EM, 2013, Piecing Together the Puzzle of Severe Malaria, Science Translational Medicine, Vol:5, ISSN:1946-6234
Cunnington AJ, Riley EM, Walther M, 2013, Stuck in a rut? Reconsidering the role of parasite sequestration in severe malaria syndromes, Trends in Parasitology, Vol:29, ISSN:1471-4922, Pages:585-592
et al., 2012, Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization, Nature Medicine, Vol:18, ISSN:1078-8956, Pages:120-127
et al., 2012, Prolonged Neutrophil Dysfunction after Plasmodium falciparum Malaria Is Related to Hemolysis and Heme Oxygenase-1 Induction, Journal of Immunology, Vol:189, ISSN:0022-1767, Pages:5336-5346