I am a Clinical Senior Lecturer at Imperial College and Honorary Consultant in Paediatric Infectious Diseases at St Mary's Hospital, Imperial College Healthcare NHS Trust. My research focuses on the interactions between hosts and pathogens which result in severe infectious diseases, particularly severe malaria. I am interested in understanding why some people get very ill and die from malaria, whilst others have a less severe illness. I am also interested in understanding how malaria causes susceptibility to other infections, such as Non-Typhoid Salmonella bacteremia. I have a MRC Clinician Scientist Fellowship to investigate the host-pathogen interactions which cause severe malaria.
You can read more about severe malaria in my recent article: "Piecing together the puzzle of severe malaria" Published in Science Translational Medicine
I am currently co-convener of the Imperial College Network of Excellence in Malaria, an interdisciplinary network of more than 100 malaria researchers at Imperial College working together to eradicate malaria: http://www.imperial.ac.uk/network-of-excellence-in-malaria/
Other aspects of my research focus on understanding and predicting susceptibility to infections in children with Sickle Cell Disease. This work is undertaken in collaboration with Dr Subarna Chakravorty and Dr Kirstin Lund and has been generously funded by The Rosetrees Trust.
I am part of the EU-Horizon 2020 PERFORM consortium which seeks to develop personalized management strategies for children with febrile illness based on new diagnostic tests.
I teach on the BSc course in Global Health, MSc courses in Immunology and Paediatrics, and short courses in Paediatric Infectious Diseases.
et al., 2015, Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1, Haematologica - the Hematology Journal, Vol:100, ISSN:0390-6078, Pages:1508-1516
Cunnington AJ, 2015, The Importance of Pathogen Load, PLOS Pathogens, Vol:11, ISSN:1553-7366
Cunnington AJ, Walther M, Riley EM, 2013, Piecing Together the Puzzle of Severe Malaria, Science Translational Medicine, Vol:5, ISSN:1946-6234
Cunnington AJ, Riley EM, Walther M, 2013, Stuck in a rut? Reconsidering the role of parasite sequestration in severe malaria syndromes, Trends in Parasitology, Vol:29, ISSN:1471-4922, Pages:585-592
et al., 2012, Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization, Nature Medicine, Vol:18, ISSN:1078-8956, Pages:120-127
et al., 2012, Prolonged Neutrophil Dysfunction after Plasmodium falciparum Malaria Is Related to Hemolysis and Heme Oxygenase-1 Induction, Journal of Immunology, Vol:189, ISSN:0022-1767, Pages:5336-5346