I am a Clinical Senior Lecturer and Honorary Consultant in Paediatric Infectious Diseases. My research focuses on the interactions between hosts and pathogens which result in severe infectious diseases, particularly relating to malaria. I am interested in understanding why some people get very ill and die from malaria, whilst others have a less severe illness. I am also interested in understanding how malaria causes susceptibility to other infections, such as Non-Typhoid Salmonella bacteremia. I have recently been awarded a MRC Clinician Scientist Fellowship to investigate the host-pathogen interactions which cause severe malaria.
You can read more about severe malaria in my recent article: "Piecing together the puzzle of severe malaria" Published in Science Translational Medicine
Another aspect of my work focuses on understanding susceptibility to infections in children with Sickle Cell Disease. This work is undertaken in collaboration with Dr Subarna Chakravorty and has been generously funded by The Rosetrees Trust.
et al., 2016, "Vaginal seeding" of infants born by caesarean section, Bmj-british Medical Journal, Vol:352, ISSN:1756-1833
Cunnington AJ, 2016, "VAGINAL SEEDING" AFTER CAESAREAN SECTION Author's reply to Banda and Lokugamage, Bmj-british Medical Journal, Vol:352, ISSN:1756-1833
et al., 2015, Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1, Haematologica, Vol:100, ISSN:0390-6078, Pages:1508-1516
Orf K, Cunnington AJ, 2015, Infection-related hemolysis and susceptibility to Gram-negative bacterial co-infection, Frontiers In Microbiology, Vol:6, ISSN:1664-302X
et al., 2015, Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis, Plos Pathogens, Vol:11, ISSN:1553-7366