Imperial College London

Dr Aubrey Cunnington

Faculty of MedicineDepartment of Medicine

Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3915a.cunnington

 
 
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Location

 

231Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

37 results found

Evans C, Fitzgerald F, Cunnington A, 2018, Review of UK malaria treatment guidelines 2016 (Public Health England Advisory Committee on Malaria Prevention)., Arch Dis Child Educ Pract Ed

JOURNAL ARTICLE

Lee HJ, Georgiadou A, Otto TD, Levin M, Coin LJ, Conway DJ, Cunnington AJet al., 2018, Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions, MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, Vol: 82, ISSN: 1092-2172

JOURNAL ARTICLE

Lee HJ, Georgiadou A, Walther M, Nwakanma D, Stewart LB, Levin M, Otto TD, Conway DJ, Coin LJ, Cunnington AJet al., 2018, Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria, SCIENCE TRANSLATIONAL MEDICINE, Vol: 10, ISSN: 1946-6234

JOURNAL ARTICLE

McArdle AJ, Turkova A, Cunnington AJ, 2018, When do co-infections matter?, CURRENT OPINION IN INFECTIOUS DISEASES, Vol: 31, Pages: 209-215, ISSN: 0951-7375

JOURNAL ARTICLE

van Beek A, Pouw R, Sarr I, Correa S, Nwakanma D, Brouwer M, Wouters D, Conway D, Walther M, Levin M, Kuijpers T, Cunnington Aet al., 2018, Complement factor H levels associate with severity of Plasmodium falciparum malaria, 27th International Complement Workshop (ICW), Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 234-234, ISSN: 0161-5890

CONFERENCE PAPER

van Beek AE, Sarr I, Correa S, Nwakanma D, Brouwer MC, Wouters D, Secka F, Anderson STB, Conway DJ, Walther M, Levin M, Kuijpers TW, Cunnington AJet al., 2018, Complement Factor H Levels Associate With Plasmodium falciparum Malaria Susceptibility and Severity., Open Forum Infect Dis, Vol: 5, ISSN: 2328-8957

Background: Plasmodium falciparum may evade complement-mediated host defense by hijacking complement Factor H (FH), a negative regulator of the alternative complement pathway. Plasma levels of FH vary between individuals and may therefore influence malaria susceptibility and severity. Methods: We measured convalescent FH plasma levels in 149 Gambian children who had recovered from uncomplicated or severe P. falciparum malaria and in 173 healthy control children. We compared FH plasma levels between children with malaria and healthy controls, and between children with severe (n = 82) and uncomplicated malaria (n = 67). We determined associations between FH plasma levels and laboratory features of severity and used multivariate analyses to examine associations with FH when accounting for other determinants of severity. Results: FH plasma levels differed significantly between controls, uncomplicated malaria cases, and severe malaria cases (mean [95% confidence interval], 257 [250 to 264], 288 [268 to 309], and 328 [313 to 344] µg/mL, respectively; analysis of variance P < .0001). FH plasma levels correlated with severity biomarkers, including lactate, parasitemia, and parasite density, but did not correlate with levels of PfHRP2, which represent the total body parasite load. Associations with severity and lactate remained significant when adjusting for age and parasite load. Conclusions: Natural variation in FH plasma levels is associated with malaria susceptibility and severity. A prospective study will be needed to strengthen evidence for causation, but our findings suggest that interfering with FH binding by P. falciparum might be useful for malaria prevention or treatment.

JOURNAL ARTICLE

Cheung R, Cunnington A, Drysdale S, Raine J, Walker Jet al., 2017, 100 Cases in Paediatrics, Second Edition, Publisher: CRC Press, ISBN: 9781315351599

The new edition of this best-selling title from the popular 100 cases series explores common paediatric scenarios that will be encountered by the medical student and junior doctor during practical training on the ward, in the emergency ...

BOOK

Ikeda AK, Rowley C, Yang Y, Okebe J, Ebonyi A, Njie M, Correa S, Jayasooriya S, Cunnington A, Casals-Pascual C, Walther M, Taylor T, Seydel K, Ackerman Het al., 2017, PLASMA HAPTOGLOBIN AS A MARKER OF CLINICAL SEVERITY IN GAMBIAN AND MALAWIAN CHILDREN INFECTED WITH PLASMODIUM FALCIPARUM, 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Publisher: AMER SOC TROP MED & HYGIENE, Pages: 464-464, ISSN: 0002-9637

CONFERENCE PAPER

Lee HJ, Walther M, Georgiadou A, Nwakanma D, Stewart L, Levin M, Otto T, Conway D, Coin L, Cunnington Aet al., 2017, Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria

The pathogenesis of severe Plasmodium falciparum malaria is incompletely understood. Since the pathogenic stage of the parasite is restricted to blood, dual RNA-sequencing of host and parasite transcripts in blood can reveal their interactions at a systemic scale. Here we identify human and parasite gene expression associated with severe disease features in Gambian children. Differences in parasite load explained up to 99% of differential expression of human genes but only a third of the differential expression of parasite genes. Co-expression analyses showed a remarkable co-regulation of host and parasite genes controlling translation, and host granulopoiesis genes uniquely co-regulated and differentially expressed in severe malaria. Our results indicate that high parasite load is the proximal stimulus for severe P. falciparum malaria, that there is an unappreciated role for many parasite genes in determining virulence, and hint at a molecular arms-race between host and parasite to synthesise protein products.

JOURNAL ARTICLE

Soothill G, Darboe S, Bah G, Bolarinde L, Cunnington A, Anderson Set al., 2017, Invasive bacterial infections in gambian patients with Sickle Cell Anemia in an era of widespread pneumococcal and haemophilus influenza type B vaccination, 22nd Congress of the European-Hematology-Association, Publisher: Ferrata Storti Foundation, Pages: 606-606, ISSN: 0390-6078

CONFERENCE PAPER

Cunnington AJ, 2016, "VAGINAL SEEDING" AFTER CAESAREAN SECTION Author's reply to Banda and Lokugamage, BMJ-BRITISH MEDICAL JOURNAL, Vol: 352, ISSN: 1756-1833

JOURNAL ARTICLE

Cunnington AJ, Sim K, Deierl A, Kroll JS, Brannigan E, Darby Jet al., 2016, "Vaginal seeding" of infants born by caesarean section, BMJ-BRITISH MEDICAL JOURNAL, Vol: 352, ISSN: 1756-1833

JOURNAL ARTICLE

McArdle AJ, Webbe J, Sim K, Parrish G, Hoggart C, Wang Y, Kroll JS, Godambe S, Cunnington AJet al., 2016, Determinants of Carboxyhemoglobin Levels and Relationship with Sepsis in a Retrospective Cohort of Preterm Neonates, PLOS ONE, Vol: 11, ISSN: 1932-6203

JOURNAL ARTICLE

Soothill G, Darboe S, Bah G, Bolarinde L, Cunnington A, Anderson STet al., 2016, Invasive bacterial infections in Gambians with sickle cell anemia in an era of widespread pneumococcal and hemophilus influenzae type b vaccination, MEDICINE, Vol: 95, ISSN: 0025-7974

JOURNAL ARTICLE

Chertow JH, Alkaitis MS, Nardone G, Ikeda AK, Cunnington AJ, Okebe J, Ebonyi AO, Njie M, Correa S, Jayasooriya S, Casals-Pascual C, Billker O, Conway DJ, Walther M, Ackerman Het al., 2015, Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis, PLOS PATHOGENS, Vol: 11, ISSN: 1553-7366

JOURNAL ARTICLE

Cunnington AJ, 2015, The Importance of Pathogen Load, PLOS PATHOGENS, Vol: 11, ISSN: 1553-7366

JOURNAL ARTICLE

Evans C, Orf K, Horvath E, Levin M, De La Fuente J, Chakravorty S, Cunnington AJet al., 2015, Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1, HAEMATOLOGICA, Vol: 100, Pages: 1508-1516, ISSN: 0390-6078

JOURNAL ARTICLE

Orf K, Cunnington AJ, 2015, Infection-related hemolysis and susceptibility to Gram-negative bacterial co-infection, FRONTIERS IN MICROBIOLOGY, Vol: 6, ISSN: 1664-302X

JOURNAL ARTICLE

Takem EN, Roca A, Cunnington A, 2014, The association between malaria and non-typhoid Salmonella bacteraemia in children in sub-Saharan Africa: a literature review, MALARIA JOURNAL, Vol: 13, ISSN: 1475-2875

JOURNAL ARTICLE

Cunnington AJ, Bretscher MT, Nogaro SI, Riley EM, Walther Met al., 2013, Comparison of parasite sequestration in uncomplicated and severe childhood Plasmodium falciparum malaria, JOURNAL OF INFECTION, Vol: 67, Pages: 220-230, ISSN: 0163-4453

JOURNAL ARTICLE

Cunnington AJ, Riley EM, Walther M, 2013, Microvascular Dysfunction in Severe Plasmodium falciparum Malaria, JOURNAL OF INFECTIOUS DISEASES, Vol: 207, Pages: 369-U180, ISSN: 0022-1899

JOURNAL ARTICLE

Cunnington AJ, Riley EM, Walther M, 2013, Stuck in a rut? Reconsidering the role of parasite sequestration in severe malaria syndromes, TRENDS IN PARASITOLOGY, Vol: 29, Pages: 585-592, ISSN: 1471-4922

JOURNAL ARTICLE

Cunnington AJ, Walther M, Riley EM, 2013, Piecing Together the Puzzle of Severe Malaria, SCIENCE TRANSLATIONAL MEDICINE, Vol: 5, ISSN: 1946-6234

JOURNAL ARTICLE

Cunnington AJ, Walther M, Riley EM, 2013, Piecing Together the Puzzle of Severe Malaria, SCIENCE TRANSLATIONAL MEDICINE, Vol: 5, ISSN: 1946-6234

JOURNAL ARTICLE

Cunnington A, Riley E, 2012, Malaria and HIV, Immunity to Parasitic Infection, Publisher: John Wiley & Sons, ISBN: 9781118393338

This book examines current knowledge about immune responses to parasitic infections affecting humans, including interactions that occur during co-infections, and how immune responses may be manipulated to develop therapeutic interventions ...

BOOK CHAPTER

Cunnington AJ, Njie M, Correa S, Takem EN, Riley EM, Walther Met al., 2012, Prolonged Neutrophil Dysfunction after Plasmodium falciparum Malaria Is Related to Hemolysis and Heme Oxygenase-1 Induction, JOURNAL OF IMMUNOLOGY, Vol: 189, Pages: 5336-5346, ISSN: 0022-1767

JOURNAL ARTICLE

Cunnington AJ, de Souza JB, Walther M, Riley EMet al., 2012, Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization, NATURE MEDICINE, Vol: 18, Pages: 120-127, ISSN: 1078-8956

JOURNAL ARTICLE

Walther M, De Caul A, Aka P, Njie M, Amambua-Ngwa A, Walther B, Predazzi IM, Cunnington A, Deininger S, Takem EN, Ebonyi A, Weis S, Walton R, Rowland-Jones S, Sirugo G, Williams SM, Conway DJet al., 2012, HMOX1 Gene Promoter Alleles and High HO-1 Levels Are Associated with Severe Malaria in Gambian Children, PLOS PATHOGENS, Vol: 8, ISSN: 1553-7366

JOURNAL ARTICLE

Zinna SS, Bamford A, Cunnington A, Kampmann B, Lyall EGH, Menson E, Heath PTet al., 2011, Immunization status of children with HIV: failure to protect a vulnerable population, HIV MEDICINE, Vol: 12, Pages: 447-448, ISSN: 1464-2662

JOURNAL ARTICLE

Cunnington A, Patel S, Lyall H, 2010, Why Are Some Babies Still Being Infected with HIV in the UK?, HOT TOPICS IN INFECTION AND IMMUNITY IN CHILDREN VI, Vol: 659, Pages: 57-71, ISSN: 0065-2598

JOURNAL ARTICLE

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