Imperial College London
Alternate

Professor the Lord Darzi of Denham PC KBE FRS FMedSci HonFREng

Faculty of Medicine, Department of Surgery & Cancer

Co-Director of the IGHI, Professor of Surgery
 
 
 
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Contact

 

+44 (0)20 3312 1310a.darzi

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Arhi:2019:10.1111/codi.14734,
author = {Arhi, CS and Ziprin, P and Bottle, A and Burns, EM and Aylin, P and Darzi, A},
doi = {10.1111/codi.14734},
journal = {Colorectal Disease},
pages = {1270--1278},
title = {Colorectal cancer patients under the age of 50 experience delays in primary care leading to emergency diagnoses: a population-based study},
url = {http://dx.doi.org/10.1111/codi.14734},
volume = {21},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AIM: The incidence of colorectal cancer in the under 50s is increasing. In this national population-based study we aim to show that missed opportunities for diagnosis in primary care are leading to referral delays and emergency diagnoses in young patients. METHOD: We compared the interval before diagnosis, presenting symptom(s) and the odds ratio (OR) of an emergency diagnosis for those under the age of 50 with older patients sourced from the cancer registry with linkage to a national database of primary-care records. RESULTS: The study included 7315 patients, of whom 508 (6.9%) were aged under 50 years, 1168 (16.0%) were aged 50-59, 2294 (31.4%) were aged 60-69 and 3345 (45.7%) were aged 70-79 years. Young patients were more likely to present with abdominal pain and via an emergency, and had the lowest percentage of early stage cancer. They experienced a longer interval between referral and diagnosis (12.5 days) than those aged 60-69, reflecting the higher proportion of referrals via the nonurgent pathway (33.3%). The OR of an emergency diagnosis did not differ with age if a red-flag symptom was noted at presentation, but increased significantly for young patients if the symptom was nonspecific. CONCLUSION: Young patients present to primary care with symptoms outside the national referral guidelines, increasing the likelihood of an emergency diagnosis.
AU  - Arhi,CS
AU  - Ziprin,P
AU  - Bottle,A
AU  - Burns,EM
AU  - Aylin,P
AU  - Darzi,A
DO  - 10.1111/codi.14734
EP  - 1278
PY  - 2019///
SN  - 1462-8910
SP  - 1270
TI  - Colorectal cancer patients under the age of 50 experience delays in primary care leading to emergency diagnoses: a population-based study
T2  - Colorectal Disease
UR  - http://dx.doi.org/10.1111/codi.14734
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31389141
UR  - http://hdl.handle.net/10044/1/72704
VL  - 21
ER  -
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