Imperial College London
Alternate

Professor the Lord Darzi of Denham PC KBE FRS FMedSci HonFREng

Faculty of Medicine, Department of Surgery & Cancer

Co-Director of the IGHI, Professor of Surgery
 
 
 
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Contact

 

+44 (0)20 3312 1310a.darzi

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Oliver:2020:10.1007/s00125-019-05061-y,
author = {Oliver, N and Johnston, D and Godsland, I and Srivanichakorn, W and Majeed, A and Darzi, A},
doi = {10.1007/s00125-019-05061-y},
journal = {Diabetologia},
pages = {486--496},
title = {A pragmatic and scalable strategy using mobile technology to promote sustained lifestyle changes to prevent Type 2 diabetes in India and the UK – a randomised controlled trial},
url = {http://dx.doi.org/10.1007/s00125-019-05061-y},
volume = {63},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Aims/hypothesis This randomised controlled trial was performed in India and UK in people with prediabetes to study whether mobile phone short message services can be used to motivate and educate people to follow lifestyle modification, to prevent type 2 diabetes.Methods The study was performed in people with prediabetes (n=2062, control: n=1031; intervention: n=1031) identified by glycosylated haemoglobin A1c42 and 47mmol/mol (6.0% and 6.4%). Participants were recruited from public and private sector organisations in India and by the NHS Health Checks programme in the UK. Allocation to the study groups was performed using a computer generated sequence (1:1) in India and by stratified randomisation in permuted blocks in the UK. Investigators in both countries remained blinded throughout the study period.  All participants received advice on healthy lifestyle at baseline. The intervention group in addition received supportive text messages using mobile phone short messaging services2-3 times per week. Participants were assessed at intervals for 2years. The primary outcome was conversion to diabetes and secondary outcomes included anthropometry, biochemistry, dietary and physical activity change, blood pressure and quality of life. Results At 2years follow-up, in the intention-to-treat population the hazard ratio for development of diabetes calculated using a discrete-time proportional hazards model was 0.89,95%CI(0.74-1.07) p=0.22. There were no significant differences in the secondary outcomes.Conclusions/Interpretation This trial in 2 countries with varied ethnic and cultural backgrounds showed no significant reduction in the progression in diabetes in 2 years by lifestyle modification using short messaging services (Hazard Ratio 0.89, 95% CI 0.74 – 1.07, p=0.22)
AU  - Oliver,N
AU  - Johnston,D
AU  - Godsland,I
AU  - Srivanichakorn,W
AU  - Majeed,A
AU  - Darzi,A
DO  - 10.1007/s00125-019-05061-y
EP  - 496
PY  - 2020///
SN  - 0012-186X
SP  - 486
TI  - A pragmatic and scalable strategy using mobile technology to promote sustained lifestyle changes to prevent Type 2 diabetes in India and the UK – a randomised controlled trial
T2  - Diabetologia
UR  - http://dx.doi.org/10.1007/s00125-019-05061-y
UR  - https://link.springer.com/article/10.1007%2Fs00125-019-05061-y
UR  - http://hdl.handle.net/10044/1/74855
VL  - 63
ER  -
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