Imperial College London
Alternate

Professor the Lord Darzi of Denham PC KBE FRS FMedSci HonFREng

Faculty of Medicine, Department of Surgery & Cancer

Co-Director of the IGHI, Professor of Surgery
 
 
 
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Contact

 

+44 (0)20 3312 1310a.darzi

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kontovounisios:2017:10.1007/s13304-017-0464-6,
author = {Kontovounisios, C and Qiu, S and Rasheed, S and Darzi, A and Tekkis, P},
doi = {10.1007/s13304-017-0464-6},
journal = {Updates in Surgery},
title = {The role of neurotensin as a novel biomarker in the endoscopic screening of high-risk population for developing colorectal neoplasia},
url = {http://dx.doi.org/10.1007/s13304-017-0464-6},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Colorectal cancer screening programs aim at early detection of cancer to reduce incidence rates and mortality. The objective of this study is to identify the role of neurotensin in the endoscopic screening of high-risk population for developing colorectal neoplasia. Blood samples from patients referred for urgent colonoscopy to investigate symptoms suspicious of colorectal cancer were collected. Blood neurotensin levels were measured using enzyme-linked immunosorbent assay. Colonoscopy findings were used as reference for determining the diagnostic accuracy of blood neurotensin. The study comprised 26 patients in total: 12 healthy and 14 with colon pathology (13 high-grade dysplasia adenomatous polyps, 1 adenocarcinoma). There were no statistically significant differences in the clinical and biochemical parameters between colon pathology and healthy group except neurotensin levels. Pathology in colon was associated with 3.7-fold increase in NT levels. In multivariate analysis, patients with pathology in colon have increased serum neurotensin levels compared to controls adjusted for age, gender, BMI and co-morbidities. The value of 12.93 pg/ml is associated with 87.5% sensitivity and 91.7% specificity for discriminating the colon pathology from normal colonic epithelium (p = 0.001). Neurotensin plasma values differentiate healthy people from patients suffering from colonic pathologies such as adenomatous polyps and cancer. The use of neurotensin as a potential endoscopic screening tool for identifying high-risk population for developing colorectal cancer is promising, but much has to be done before it is validated in larger scale prospective studies.
AU  - Kontovounisios,C
AU  - Qiu,S
AU  - Rasheed,S
AU  - Darzi,A
AU  - Tekkis,P
DO  - 10.1007/s13304-017-0464-6
PY  - 2017///
SN  - 2038-131X
TI  - The role of neurotensin as a novel biomarker in the endoscopic screening of high-risk population for developing colorectal neoplasia
T2  - Updates in Surgery
UR  - http://dx.doi.org/10.1007/s13304-017-0464-6
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28560510
UR  - http://hdl.handle.net/10044/1/49289
ER  -
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