Imperial College London
Alternate

Professor the Lord Darzi of Denham PC KBE FRS FMedSci HonFREng

Faculty of Medicine, Department of Surgery & Cancer

Co-Director of the IGHI, Professor of Surgery
 
 
 
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Contact

 

+44 (0)20 3312 1310a.darzi

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Moussa:2019:10.1097/SLA.0000000000002730,
author = {Moussa, OM and Erridge, S and Chidambaram, S and Ziprin, P and Darzi, A and Purkayastha, S},
doi = {10.1097/SLA.0000000000002730},
journal = {Annals of Surgery},
pages = {1087--1091},
title = {Mortality of the severely obese: a population study},
url = {http://dx.doi.org/10.1097/SLA.0000000000002730},
volume = {269},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: This study aimed to analyze the Clinical Practice Research Datalink to identify the prognostic factors of all-cause mortality in the severely obese. BACKGROUND: Patients who are severely obese [body mass index (BMI) ≥35kg/m] are at increased risk of all-cause mortality as a result of metabolic sequelae including hyperlipidemia, hypertension, and diabetes. Bariatric surgery has been shown to reduce the severity of the metabolic complications of obesity. METHOD: A case-controlled analysis was carried out of patients with a BMI of 35kg/m or more from the Clinical Practice Research Datalink, a UK database of primary care clinics. Clinicopathological characteristics at baseline diagnosis were extracted. Cases of all-cause mortality were identified as a clinical endpoint. A Cox proportional hazard model was used to calculate hazard ratios (HRs) for different patient factors. A P value less than 0.050 was defined as significant. RESULTS: A total of 187,061 records were identified for analysis. Median follow-up time was 98.0 months (range: 3.0-1095.0). A total of 8655(4.6%) were identified as having died during the study period. The median time from baseline obesity diagnosis until death was 137.0 months (range: 3.0-628.7). Multivariate analysis found bariatric surgery to be associated with reduced risk of all-cause mortality (HR: 0.487; P < 0.001). The following were associated with increased risk of death: male sex (HR: 1.805; P < 0.001), BMI of 60 or greater (HR: 2.541; P < 0.001), hypertension (HR: 2.108; P < 0.001), diabetes (HR: 2.766; P < 0.001), and hyperlipidemia (HR: 1.641; P < 0.001). CONCLUSIONS: Factors such as high BMI, diabetes, hyperlipidemia, and hypertension at first diagnosis of severe obesity were each independently associated with an increased risk of death. Bariatric surgery was shown to be associated with reduced risk of all-cause mortality. Improving access to bariatric surgery and public health campaigns can improve
AU  - Moussa,OM
AU  - Erridge,S
AU  - Chidambaram,S
AU  - Ziprin,P
AU  - Darzi,A
AU  - Purkayastha,S
DO  - 10.1097/SLA.0000000000002730
EP  - 1091
PY  - 2019///
SN  - 0003-4932
SP  - 1087
TI  - Mortality of the severely obese: a population study
T2  - Annals of Surgery
UR  - http://dx.doi.org/10.1097/SLA.0000000000002730
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29521741
UR  - https://journals.lww.com/annalsofsurgery/Fulltext/2019/06000/Mortality_of_the_Severely_Obese__A_Population.14.aspx
UR  - http://hdl.handle.net/10044/1/59361
VL  - 269
ER  -
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