Imperial College London

DrAbbasDehghan

Faculty of MedicineSchool of Public Health

Reader in Cardiometabolic Disease Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
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Location

 

157Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ghanbari:2018:10.1038/s10038-017-0403-x,
author = {Ghanbari, M and Peters, MJ and De, Vries PS and Boer, CG and Van, Rooij JGJ and Lee, YC and Kumar, V and Uitterlinden, AG and Ikram, MA and Wijmenga, C and Ordovas, JM and Smith, CE and Van, Meurs JBJ and Erkeland, SJ and Franco, OH and Dehghan, A},
doi = {10.1038/s10038-017-0403-x},
journal = {Journal of Human Genetics},
pages = {431--446},
title = {A systematic analysis highlights multiple long non-coding RNAs associated with cardiometabolic disorders},
url = {http://dx.doi.org/10.1038/s10038-017-0403-x},
volume = {63},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Genome-wide association studies (GWAS) have identified many susceptibility loci for cardiometabolic disorders. Most of the associated variants reside in non-coding regions of the genome including long non-coding RNAs (lncRNAs), which are thought to play critical roles in diverse biological processes. Here, we leveraged data from the available GWAS meta-analyses on lipid and obesity-related traits, blood pressure, type 2 diabetes, and coronary artery disease and identified 179 associated single-nucleotide polymorphisms (SNPs) in 102 lncRNAs (p-value < 2.3 × 10-7). Of these, 55 SNPs, either the lead SNP or in strong linkage disequilibrium with the lead SNP in the related loci, were selected for further investigations. Our in silico predictions and functional annotations of the SNPs as well as expression and DNA methylation analysis of their lncRNAs demonstrated several lncRNAs that fulfilled predefined criteria for being potential functional targets. In particular, we found evidence suggesting that LOC157273 (at 8p23.1) is involved in regulating serum lipid-cholesterol. Our results showed that rs4841132 in the second exon and cg17371580 in the promoter region of LOC157273 are associated with lipids; the lncRNA is expressed in liver and associates with the expression of its nearby coding gene, PPP1R3B. Collectively, we highlight a number of loci associated with cardiometabolic disorders for which the association may act through lncRNAs.
AU - Ghanbari,M
AU - Peters,MJ
AU - De,Vries PS
AU - Boer,CG
AU - Van,Rooij JGJ
AU - Lee,YC
AU - Kumar,V
AU - Uitterlinden,AG
AU - Ikram,MA
AU - Wijmenga,C
AU - Ordovas,JM
AU - Smith,CE
AU - Van,Meurs JBJ
AU - Erkeland,SJ
AU - Franco,OH
AU - Dehghan,A
DO - 10.1038/s10038-017-0403-x
EP - 446
PY - 2018///
SN - 1434-5161
SP - 431
TI - A systematic analysis highlights multiple long non-coding RNAs associated with cardiometabolic disorders
T2 - Journal of Human Genetics
UR - http://dx.doi.org/10.1038/s10038-017-0403-x
UR - http://hdl.handle.net/10044/1/60610
VL - 63
ER -