Imperial College London

DrAbbasDehghan

Faculty of MedicineSchool of Public Health

Reader in Cardiometabolic Disease Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
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Location

 

157Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Dehghan:2018:10.1007/978-1-4939-7868-7_4,
author = {Dehghan, A},
doi = {10.1007/978-1-4939-7868-7_4},
pages = {37--49},
title = {Genome-Wide Association Studies.},
url = {http://dx.doi.org/10.1007/978-1-4939-7868-7_4},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - CHAP
AB - Genetic association studies have made a major contribution to our understanding of the genetics of complex disorders over the last 10 years through genome-wide association studies (GWAS). In this chapter, we review the key concepts that underlie the GWAS approach. We will describe the "common disease, common variant" theory, and will review how we finally afforded to capture the common variance in genome to make GWAS possible. Finally, we will go over technical aspects of GWAS such as genotype imputation, epidemiologic designs, analysis methods, and considerations such as genomic inflation, multiple testing, and replication.
AU - Dehghan,A
DO - 10.1007/978-1-4939-7868-7_4
EP - 49
PY - 2018///
SP - 37
TI - Genome-Wide Association Studies.
UR - http://dx.doi.org/10.1007/978-1-4939-7868-7_4
UR - https://www.ncbi.nlm.nih.gov/pubmed/29876890
ER -