Imperial College London

DrAbbasDehghan

Faculty of MedicineSchool of Public Health

Reader in Cardiometabolic Disease Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
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Location

 

157Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mahajan:2018:10.1038/s41588-018-0241-6,
author = {Mahajan, A and Taliun, D and Thurner, M and Robertson, NR and Torres, JM and Rayner, NW and Payne, AJ and Steinthorsdottir, V and Scott, RA and Grarup, N and Cook, JP and Schmidt, EM and Wuttke, M and Sarnowski, C and Magill, R and Nano, J and Gieger, C and Trompet, S and Lecoeur, C and Preuss, MH and Prins, BP and Guo, X and Bielak, LF and Below, JE and Bowden, DW and Chambers, JC and Kim, YJ and Ng, MCY and Petty, LE and Sim, X and Zhang, W and Bennett, AJ and Bork-Jensen, J and Brummett, CM and Canouil, M and Kardt, K-UE and Fischer, K and Kardia, SLR and Kronenberg, F and Lall, K and Liu, C-T and Locke, AE and Luan, J and Ntalla, L and Nylander, V and Schoenherr, S and Schurmann, C and Yengo, L and Bottinger, EP and Brandslund, I and Christensen, C and Dedoussis, G and Florez, JC and Ford, I and France, OH and Frayling, TM and Giedraitis, V and Hackinger, S and Hattersley, AT and Herder, C and Ikram, MA and Ingelsson, M and Jorgensen, ME and Jorgensen, T and Kriebel, J and Kuusisto},
doi = {10.1038/s41588-018-0241-6},
journal = {Nature Genetics},
pages = {1505--1515},
title = {Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps},
url = {http://dx.doi.org/10.1038/s41588-018-0241-6},
volume = {50},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loci, 135 newly implicated in T2D predisposition, comprising 403 distinct association signals); (ii) enrich discovery of lower-frequency risk alleles (80 index variants with minor allele frequency <5%, 14 with estimated allelic odds ratio >2); (iii) substantially improve fine-mapping of causal variants (at 51 signals, one variant accounted for >80% posterior probability of association (PPA)); (iv) extend fine-mapping through integration of tissue-specific epigenomic information (islet regulatory annotations extend the number of variants with PPA >80% to 73); (v) highlight validated therapeutic targets (18 genes with associations attributable to coding variants); and (vi) demonstrate enhanced potential for clinical translation (genome-wide chip heritability explains 18% of T2D risk; individuals in the extremes of a T2D polygenic risk score differ more than ninefold in prevalence).
AU - Mahajan,A
AU - Taliun,D
AU - Thurner,M
AU - Robertson,NR
AU - Torres,JM
AU - Rayner,NW
AU - Payne,AJ
AU - Steinthorsdottir,V
AU - Scott,RA
AU - Grarup,N
AU - Cook,JP
AU - Schmidt,EM
AU - Wuttke,M
AU - Sarnowski,C
AU - Magill,R
AU - Nano,J
AU - Gieger,C
AU - Trompet,S
AU - Lecoeur,C
AU - Preuss,MH
AU - Prins,BP
AU - Guo,X
AU - Bielak,LF
AU - Below,JE
AU - Bowden,DW
AU - Chambers,JC
AU - Kim,YJ
AU - Ng,MCY
AU - Petty,LE
AU - Sim,X
AU - Zhang,W
AU - Bennett,AJ
AU - Bork-Jensen,J
AU - Brummett,CM
AU - Canouil,M
AU - Kardt,K-UE
AU - Fischer,K
AU - Kardia,SLR
AU - Kronenberg,F
AU - Lall,K
AU - Liu,C-T
AU - Locke,AE
AU - Luan,J
AU - Ntalla,L
AU - Nylander,V
AU - Schoenherr,S
AU - Schurmann,C
AU - Yengo,L
AU - Bottinger,EP
AU - Brandslund,I
AU - Christensen,C
AU - Dedoussis,G
AU - Florez,JC
AU - Ford,I
AU - France,OH
AU - Frayling,TM
AU - Giedraitis,V
AU - Hackinger,S
AU - Hattersley,AT
AU - Herder,C
AU - Ikram,MA
AU - Ingelsson,M
AU - Jorgensen,ME
AU - Jorgensen,T
AU - Kriebel,J
AU - Kuusisto,J
AU - Ligthart,S
AU - Lindgren,CM
AU - Linneberg,A
AU - Lyssenko,V
AU - Mamakou,V
AU - Meitinger,T
AU - Mohlke,KL
AU - Morris,AD
AU - Nadkarni,G
AU - Pankow,JS
AU - Peters,A
AU - Sattar,N
AU - Stancakova,A
AU - Strauch,K
AU - Taylor,KD
AU - Thorand,B
AU - Thorleifsson,G
AU - Thorsteinsdottir,U
AU - Tuomilehto,J
AU - Witte,DR
AU - Dupuis,J
AU - Peyser,PA
AU - Zeggini,E
AU - Loos,RJF
AU - Froguel,P
AU - Ingelsson,E
AU - Lind,L
AU - Groop,L
AU - Laakso,M
AU - Collins,FS
AU - Jukema,JW
AU - Palmer,CNA
AU - Grallert,H
AU - Metspalu,A
AU - Dehghan,A
AU - Koettgen,A
AU - Abecasis,GR
AU - Meigs,JB
AU - Rotter,J
AU - Marchini,J
AU - Pedersen,O
AU - Hansen,T
AU - Langenberg,C
AU - Wareham,NJ
AU - Stefansson,K
AU - Gloyn,AL
AU - Morris,AP
AU - Boehnke,M
AU - McCarthy,M
DO - 10.1038/s41588-018-0241-6
EP - 1515
PY - 2018///
SN - 1061-4036
SP - 1505
TI - Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
T2 - Nature Genetics
UR - http://dx.doi.org/10.1038/s41588-018-0241-6
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000448398000006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/64303
VL - 50
ER -