Imperial College London

DrAbbasDehghan

Faculty of MedicineSchool of Public Health

Reader in Cardiometabolic Disease Epidemiology
 
 
 
//

Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
//

Location

 

157Norfolk PlaceSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Tylee:2018:10.1002/ajmg.b.32652,
author = {Tylee, DS and Sun, J and Hess, JL and Tahir, MA and Sharma, E and Malik, R and Worrall, BB and Levine, AJ and Martinson, JJ and Nejentsev, S and Speed, D and Fischer, A and Mick, E and Walker, BR and Crawford, A and Grant, SFA and Polychronakos, C and Bradfield, JP and Sleiman, PMA and Hakonarson, H and Ellinghaus, E and Elder, JT and Tsoi, LC and Trembath, RC and Barker, JN and Franke, A and Dehghan, A and 23, and Me Research Team and Inflammation, Working Group of the CHARGE Consortium and METASTROKE, Consortium of the International Stroke Genetics Consortium and Netherlands, Twin Registry and neuroCHARGE, Working Group and Obsessive, Compulsive and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium and Faraone, SV and Glatt, SJ},
doi = {10.1002/ajmg.b.32652},
journal = {Am J Med Genet B Neuropsychiatr Genet},
pages = {641--657},
title = {Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data.},
url = {http://dx.doi.org/10.1002/ajmg.b.32652},
volume = {177},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Individuals with psychiatric disorders have elevated rates of autoimmune comorbidity and altered immune signaling. It is unclear whether these altered immunological states have a shared genetic basis with those psychiatric disorders. The present study sought to use existing summary-level data from previous genome-wide association studies to determine if commonly varying single nucleotide polymorphisms are shared between psychiatric and immune-related phenotypes. We estimated heritability and examined pair-wise genetic correlations using the linkage disequilibrium score regression (LDSC) and heritability estimation from summary statistics methods. Using LDSC, we observed significant genetic correlations between immune-related disorders and several psychiatric disorders, including anorexia nervosa, attention deficit-hyperactivity disorder, bipolar disorder, major depression, obsessive compulsive disorder, schizophrenia, smoking behavior, and Tourette syndrome. Loci significantly mediating genetic correlations were identified for schizophrenia when analytically paired with Crohn's disease, primary biliary cirrhosis, systemic lupus erythematosus, and ulcerative colitis. We report significantly correlated loci and highlight those containing genome-wide associations and candidate genes for respective disorders. We also used the LDSC method to characterize genetic correlations among the immune-related phenotypes. We discuss our findings in the context of relevant genetic and epidemiological literature, as well as the limitations and caveats of the study.
AU - Tylee,DS
AU - Sun,J
AU - Hess,JL
AU - Tahir,MA
AU - Sharma,E
AU - Malik,R
AU - Worrall,BB
AU - Levine,AJ
AU - Martinson,JJ
AU - Nejentsev,S
AU - Speed,D
AU - Fischer,A
AU - Mick,E
AU - Walker,BR
AU - Crawford,A
AU - Grant,SFA
AU - Polychronakos,C
AU - Bradfield,JP
AU - Sleiman,PMA
AU - Hakonarson,H
AU - Ellinghaus,E
AU - Elder,JT
AU - Tsoi,LC
AU - Trembath,RC
AU - Barker,JN
AU - Franke,A
AU - Dehghan,A
AU - 23,and Me Research Team
AU - Inflammation,Working Group of the CHARGE Consortium
AU - METASTROKE,Consortium of the International Stroke Genetics Consortium
AU - Netherlands,Twin Registry
AU - neuroCHARGE,Working Group
AU - Obsessive,Compulsive and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium
AU - Faraone,SV
AU - Glatt,SJ
DO - 10.1002/ajmg.b.32652
EP - 657
PY - 2018///
SP - 641
TI - Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data.
T2 - Am J Med Genet B Neuropsychiatr Genet
UR - http://dx.doi.org/10.1002/ajmg.b.32652
UR - https://www.ncbi.nlm.nih.gov/pubmed/30325587
VL - 177
ER -