Imperial College London

DrAbbasDehghan

Faculty of MedicineSchool of Public Health

Reader in Cardiometabolic Disease Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
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Location

 

157Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Inker:2019:10.1053/j.ajkd.2018.08.013,
author = {Inker, LA and Grams, ME and Levey, AS and Coresh, J and Cirillo, M and Collins, JF and Gansevoort, RT and Gutierrez, OM and Hamano, T and Heine, GH and Ishikawa, S and Jee, SH and Kronenberg, F and Landray, MJ and Miura, K and Nadkarni, GN and Peralta, CA and Rothenbacher, D and Schaeffner, E and Sedaghat, S and Shlipak, MG and Zhang, L and van, Zuilen AD and Hallan, SI and Kovesdy, CP and Woodward, M and Levin, A and CKD, Prognosis Consortium},
doi = {10.1053/j.ajkd.2018.08.013},
journal = {Am J Kidney Dis},
pages = {206--217},
title = {Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium.},
url = {http://dx.doi.org/10.1053/j.ajkd.2018.08.013},
volume = {73},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - RATIONALE & OBJECTIVE: Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities and hypertension with the estimated glomerular filtration rate (eGFR) and albuminuria CKD staging framework. STUDY DESIGN: Cross-sectional individual participant-level analyses in a global consortium. SETTING & STUDY POPULATIONS: 17 CKD and 38 general population and high-risk cohorts. SELECTION CRITERIA FOR STUDIES: Cohorts in the CKD Prognosis Consortium with data for eGFR and albuminuria, as well as a measurement of hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, or calcium, or hypertension. DATA EXTRACTION: Data were obtained and analyzed between July 2015 and January 2018. ANALYTICAL APPROACH: We modeled the association of eGFR and albuminuria with hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, and calcium values using linear regression and with hypertension and categorical definitions of each abnormality using logistic regression. Results were pooled using random-effects meta-analyses. RESULTS: The CKD cohorts (n=254,666 participants) were 27% women and 10% black, with a mean age of 69 (SD, 12) years. The general population/high-risk cohorts (n=1,758,334) were 50% women and 2% black, with a mean age of 50 (16) years. There was a strong graded association between lower eGFR and all laboratory result abnormalities (ORs ranging from 3.27 [95% CI, 2.68-3.97] to 8.91 [95% CI, 7.22-10.99] comparing eGFRs of 15 to 29 with eGFRs of 45 to 59mL/min/1.73m2), whereas albuminuria had equivocal or weak associations with abnormalities (ORs ranging from 0.77 [95% CI, 0.60-0.99] to 1.92 [95% CI, 1.65-2.24] comparing urinary albumin-creatinine ratio > 300 vs < 30mg/g). LIMITATIONS: Variations in study era, health care delivery system, typical diet, and laboratory
AU - Inker,LA
AU - Grams,ME
AU - Levey,AS
AU - Coresh,J
AU - Cirillo,M
AU - Collins,JF
AU - Gansevoort,RT
AU - Gutierrez,OM
AU - Hamano,T
AU - Heine,GH
AU - Ishikawa,S
AU - Jee,SH
AU - Kronenberg,F
AU - Landray,MJ
AU - Miura,K
AU - Nadkarni,GN
AU - Peralta,CA
AU - Rothenbacher,D
AU - Schaeffner,E
AU - Sedaghat,S
AU - Shlipak,MG
AU - Zhang,L
AU - van,Zuilen AD
AU - Hallan,SI
AU - Kovesdy,CP
AU - Woodward,M
AU - Levin,A
AU - CKD,Prognosis Consortium
DO - 10.1053/j.ajkd.2018.08.013
EP - 217
PY - 2019///
SP - 206
TI - Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium.
T2 - Am J Kidney Dis
UR - http://dx.doi.org/10.1053/j.ajkd.2018.08.013
UR - https://www.ncbi.nlm.nih.gov/pubmed/30348535
VL - 73
ER -