Imperial College London

DrAbbasDehghan

Faculty of MedicineSchool of Public Health

Reader in Cardiometabolic Disease Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
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Location

 

157Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dhana:2018:aje/kwy025,
author = {Dhana, K and Braun, KVE and Nano, J and Voortman, T and Demerath, EW and Guan, W and Fornage, M and van, Meurs JBJ and Uitterlinden, AG and Hofman, A and Franco, OH and Dehghan, A},
doi = {aje/kwy025},
journal = {Am J Epidemiol},
pages = {1662--1669},
title = {An Epigenome-Wide Association Study of Obesity-Related Traits.},
url = {http://dx.doi.org/10.1093/aje/kwy025},
volume = {187},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - We conducted an epigenome-wide association study on obesity-related traits. We used data from 2 prospective, population-based cohort studies: the Rotterdam Study (RS) (2006-2013) and the Atherosclerosis Risk in Communities (ARIC) Study (1990-1992). We used the RS (n = 1,450) as the discovery panel and the ARIC Study (n = 2,097) as the replication panel. Linear mixed-effect models were used to assess the cross-sectional associations between genome-wide DNA methylation in leukocytes and body mass index (BMI) and waist circumference (WC), adjusting for sex, age, smoking, leukocyte proportions, array number, and position on array. The latter 2 variables were modeled as random effects. Fourteen 5'-C-phosphate-G-3' (CpG) sites were associated with BMI and 26 CpG sites with WC in the RS after Bonferroni correction (P < 1.07 × 10-7), of which 12 and 13 CpGs were replicated in the ARIC Study, respectively. The most significant novel CpGs were located on the Musashi RNA binding protein 2 gene (MSI2; cg21139312) and the leucyl-tRNA synthetase 2, mitochondrial gene (LARS2; cg18030453) and were associated with both BMI and WC. CpGs at BRDT, PSMD1, IFI44L, MAP1A, and MAP3K5 were associated with BMI. CpGs at LGALS3BP, MAP2K3, DHCR24, CPSF4L, and TMEM49 were associated with WC. We report novel associations between methylation at MSI2 and LARS2 and obesity-related traits. These results provide further insight into mechanisms underlying obesity-related traits, which can enable identification of new biomarkers in obesity-related chronic diseases.
AU - Dhana,K
AU - Braun,KVE
AU - Nano,J
AU - Voortman,T
AU - Demerath,EW
AU - Guan,W
AU - Fornage,M
AU - van,Meurs JBJ
AU - Uitterlinden,AG
AU - Hofman,A
AU - Franco,OH
AU - Dehghan,A
DO - aje/kwy025
EP - 1669
PY - 2018///
SP - 1662
TI - An Epigenome-Wide Association Study of Obesity-Related Traits.
T2 - Am J Epidemiol
UR - http://dx.doi.org/10.1093/aje/kwy025
UR - https://www.ncbi.nlm.nih.gov/pubmed/29762635
VL - 187
ER -