Imperial College London

DrAbbasDehghan

Faculty of MedicineSchool of Public Health

Reader in Cardiometabolic Disease Epidemiology
 
 
 
//

Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
//

Location

 

157Norfolk PlaceSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Ward-Caviness:2018:10.1182/blood-2018-02-831347,
author = {Ward-Caviness, CK and Huffman, JE and Everett, K and Germain, M and van, Dongen J and Hill, WD and Jhun, MA and Brody, JA and Ghanbari, M and Du, L and Roetker, NS and de, Vries PS and Waldenberger, M and Gieger, C and Wolf, P and Prokisch, H and Koenig, W and O'Donnell, CJ and Levy, D and Liu, C and Truong, V and Wells, PS and Trégouët, D-A and Tang, W and Morrison, AC and Boerwinkle, E and Wiggins, KL and McKnight, B and Guo, X and Psaty, BM and Sotoodenia, N and Boomsma, DI and Willemsen, G and Ligthart, L and Deary, IJ and Zhao, W and Ware, EB and Kardia, SLR and Van, Meurs JBJ and Uitterlinden, AG and Franco, OH and Eriksson, P and Franco-Cereceda, A and Pankow, JS and Johnson, AD and Gagnon, F and Morange, P-E and de, Geus EJC and Starr, JM and Smith, JA and Dehghan, A and Björck, HM and Smith, NL and Peters, A},
doi = {10.1182/blood-2018-02-831347},
journal = {Blood},
pages = {1842--1850},
title = {DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis.},
url = {http://dx.doi.org/10.1182/blood-2018-02-831347},
volume = {132},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Many hemostatic factors are associated with age and age-related diseases; however, much remains unknown about the biological mechanisms linking aging and hemostatic factors. DNA methylation is a novel means by which to assess epigenetic aging, which is a measure of age and the aging processes as determined by altered epigenetic states. We used a meta-analysis approach to examine the association between measures of epigenetic aging and hemostatic factors, as well as a clotting time measure. For fibrinogen, we performed European and African ancestry-specific meta-analyses which were then combined via a random effects meta-analysis. For all other measures we could not estimate ancestry-specific effects and used a single fixed effects meta-analysis. We found that 1-year higher extrinsic epigenetic age as compared with chronological age was associated with higher fibrinogen (0.004 g/L/y; 95% confidence interval, 0.001-0.007; P = .01) and plasminogen activator inhibitor 1 (PAI-1; 0.13 U/mL/y; 95% confidence interval, 0.07-0.20; P = 6.6 × 10-5) concentrations, as well as lower activated partial thromboplastin time, a measure of clotting time. We replicated PAI-1 associations using an independent cohort. To further elucidate potential functional mechanisms, we associated epigenetic aging with expression levels of the PAI-1 protein encoding gene (SERPINE1) and the 3 fibrinogen subunit-encoding genes (FGA, FGG, and FGB) in both peripheral blood and aorta intima-media samples. We observed associations between accelerated epigenetic aging and transcription of FGG in both tissues. Collectively, our results indicate that accelerated epigenetic aging is associated with a procoagulation hemostatic profile, and that epigenetic aging may regulate hemostasis in part via gene transcription.
AU - Ward-Caviness,CK
AU - Huffman,JE
AU - Everett,K
AU - Germain,M
AU - van,Dongen J
AU - Hill,WD
AU - Jhun,MA
AU - Brody,JA
AU - Ghanbari,M
AU - Du,L
AU - Roetker,NS
AU - de,Vries PS
AU - Waldenberger,M
AU - Gieger,C
AU - Wolf,P
AU - Prokisch,H
AU - Koenig,W
AU - O'Donnell,CJ
AU - Levy,D
AU - Liu,C
AU - Truong,V
AU - Wells,PS
AU - Trégouët,D-A
AU - Tang,W
AU - Morrison,AC
AU - Boerwinkle,E
AU - Wiggins,KL
AU - McKnight,B
AU - Guo,X
AU - Psaty,BM
AU - Sotoodenia,N
AU - Boomsma,DI
AU - Willemsen,G
AU - Ligthart,L
AU - Deary,IJ
AU - Zhao,W
AU - Ware,EB
AU - Kardia,SLR
AU - Van,Meurs JBJ
AU - Uitterlinden,AG
AU - Franco,OH
AU - Eriksson,P
AU - Franco-Cereceda,A
AU - Pankow,JS
AU - Johnson,AD
AU - Gagnon,F
AU - Morange,P-E
AU - de,Geus EJC
AU - Starr,JM
AU - Smith,JA
AU - Dehghan,A
AU - Björck,HM
AU - Smith,NL
AU - Peters,A
DO - 10.1182/blood-2018-02-831347
EP - 1850
PY - 2018///
SP - 1842
TI - DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis.
T2 - Blood
UR - http://dx.doi.org/10.1182/blood-2018-02-831347
UR - https://www.ncbi.nlm.nih.gov/pubmed/30042098
VL - 132
ER -