Imperial College London

DrAbbasDehghan

Faculty of MedicineSchool of Public Health

Reader in Cardiometabolic Disease Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
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Location

 

157Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Franceschini:2018:10.1038/s41467-018-07340-5,
author = {Franceschini, N and Giambartolomei, C and de, Vries PS and Finan, C and Bis, JC and Huntley, RP and Lovering, RC and Tajuddin, SM and Winkler, TW and Graff, M and Kavousi, M and Dale, C and Smith, AV and Hofer, E and van, Leeuwen EM and Nolte, IM and Lu, L and Scholz, M and Sargurupremraj, M and Pitkänen, N and Franzén, O and Joshi, PK and Noordam, R and Marioni, RE and Hwang, S-J and Musani, SK and Schminke, U and Palmas, W and Isaacs, A and Correa, A and Zonderman, AB and Hofman, A and Teumer, A and Cox, AJ and Uitterlinden, AG and Wong, A and Smit, AJ and Newman, AB and Britton, A and Ruusalepp, A and Sennblad, B and Hedblad, B and Pasaniuc, B and Penninx, BW and Langefeld, CD and Wassel, CL and Tzourio, C and Fava, C and Baldassarre, D and O'Leary, DH and Teupser, D and Kuh, D and Tremoli, E and Mannarino, E and Grossi, E and Boerwinkle, E and Schadt, EE and Ingelsson, E and Veglia, F and Rivadeneira, F and Beutner, F and Chauhan, G and Heiss, G and Snieder, H and Campbell, H and V},
doi = {10.1038/s41467-018-07340-5},
journal = {Nat Commun},
title = {GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.},
url = {http://dx.doi.org/10.1038/s41467-018-07340-5},
volume = {9},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans.
AU - Franceschini,N
AU - Giambartolomei,C
AU - de,Vries PS
AU - Finan,C
AU - Bis,JC
AU - Huntley,RP
AU - Lovering,RC
AU - Tajuddin,SM
AU - Winkler,TW
AU - Graff,M
AU - Kavousi,M
AU - Dale,C
AU - Smith,AV
AU - Hofer,E
AU - van,Leeuwen EM
AU - Nolte,IM
AU - Lu,L
AU - Scholz,M
AU - Sargurupremraj,M
AU - Pitkänen,N
AU - Franzén,O
AU - Joshi,PK
AU - Noordam,R
AU - Marioni,RE
AU - Hwang,S-J
AU - Musani,SK
AU - Schminke,U
AU - Palmas,W
AU - Isaacs,A
AU - Correa,A
AU - Zonderman,AB
AU - Hofman,A
AU - Teumer,A
AU - Cox,AJ
AU - Uitterlinden,AG
AU - Wong,A
AU - Smit,AJ
AU - Newman,AB
AU - Britton,A
AU - Ruusalepp,A
AU - Sennblad,B
AU - Hedblad,B
AU - Pasaniuc,B
AU - Penninx,BW
AU - Langefeld,CD
AU - Wassel,CL
AU - Tzourio,C
AU - Fava,C
AU - Baldassarre,D
AU - O'Leary,DH
AU - Teupser,D
AU - Kuh,D
AU - Tremoli,E
AU - Mannarino,E
AU - Grossi,E
AU - Boerwinkle,E
AU - Schadt,EE
AU - Ingelsson,E
AU - Veglia,F
AU - Rivadeneira,F
AU - Beutner,F
AU - Chauhan,G
AU - Heiss,G
AU - Snieder,H
AU - Campbell,H
AU - Völzke,H
AU - Markus,HS
AU - Deary,IJ
AU - Jukema,JW
AU - de,Graaf J
AU - Price,J
AU - Pott,J
AU - Hopewell,JC
AU - Liang,J
AU - Thiery,J
AU - Engmann,J
AU - Gertow,K
AU - Rice,K
AU - Taylor,KD
AU - Dhana,K
AU - Kiemeney,LALM
AU - Lind,L
AU - Raffield,LM
AU - Launer,LJ
AU - Holdt,LM
AU - Dörr,M
AU - Dichgans,M
AU - Traylor,M
AU - Sitzer,M
AU - Kumari,M
AU - Kivimaki,M
AU - Nalls,MA
AU - Melander,O
AU - Raitakari,O
AU - Franco,OH
AU - Rueda-Ochoa,OL
AU - Roussos,P
AU - Whincup,PH
AU - Amouyel,P
AU - Giral,P
AU - Anugu,P
AU - Wong,Q
AU - Malik,R
AU - Rauramaa,R
AU - Burkhardt,R
AU - Hardy,R
AU - Schmidt,R
AU - de,Mutsert R
AU - Morris,RW
AU - Strawbridge,RJ
AU - Wannamethee,SG
AU - Hägg,S
AU - Shah,S
AU - McLachlan,S
AU - Trompet,S
AU - Seshadri,S
AU - Kurl,S
AU - Heckbert,SR
AU - Ring,S
AU - Harris,TB
AU - Lehtimäki,T
AU - Galesloot,TE
AU - Shah,T
AU - de,Faire U
AU - Plagnol,V
AU - Rosamond,WD
AU - Post,W
AU - Zhu,X
AU - Zhang,X
AU - Guo,X
AU - Saba,Y
AU - MEGASTROKE,Consortium
AU - Dehghan,A
AU - Seldenrijk,A
AU - Morrison,AC
AU - Hamsten,A
AU - Psaty,BM
AU - van,Duijn CM
AU - Lawlor,DA
AU - Mook-Kanamori,DO
AU - Bowden,DW
AU - Schmidt,H
AU - Wilson,JF
AU - Wilson,JG
AU - Rotter,JI
AU - Wardlaw,JM
AU - Deanfield,J
AU - Halcox,J
AU - Lyytikäinen,L-P
AU - Loeffler,M
AU - Evans,MK
AU - Debette,S
AU - Humphries,SE
AU - Völker,U
AU - Gudnason,V
AU - Hingorani,AD
AU - Björkegren,JLM
AU - Casas,JP
AU - O'Donnell,CJ
DO - 10.1038/s41467-018-07340-5
PY - 2018///
TI - GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.
T2 - Nat Commun
UR - http://dx.doi.org/10.1038/s41467-018-07340-5
UR - https://www.ncbi.nlm.nih.gov/pubmed/30510157
UR - http://hdl.handle.net/10044/1/67378
VL - 9
ER -