Imperial College London

DrAbbasDehghan

Faculty of MedicineSchool of Public Health

Reader in Cardiometabolic Disease Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
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Location

 

157Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wensley:2011:10.1136/bmj.d548,
author = {Wensley, F and Gao, P and Burgess, S and Kaptoge, S and Di, Angelantonio E and Shah, T and Engert, JC and Clarke, R and Davey-Smith, G and Nordestgaard, BG and Saleheen, D and Samani, NJ and Sandhu, M and Anand, S and Pepys, MB and Smeeth, L and Whittaker, J and Casas, JP and Thompson, SG and Hingorani, AD and Danesh, J and Eiriksdottir, G and Harris, TB and Launer, LJ and Gudnason, V and Folsom, AR and Andrews, G and Ballantyne, CM and Samani, NJ and Hall, AS and Braund, PS and Balmforth, AJ and Whincup, PH and Morris, R and Lawlor, DA and Lowe, GDO and Timpson, N and Ebrahim, S and Ben-Shlomo, Y and Davey-Smith, G and Timpson, N and Nordestgaard, BG and Tybjaerg-Hansen, A and Zacho, J and Brown, M and Sandhu, M and Ricketts, SL and Ashford, S and Lange, L and Reiner, A and Cushman, M and Tracy, R and Wu, C and Ge, J and Zou, Y and Sun, A and Hung, J and McQuillan, B and Thompson, P and Beilby, J and Warrington, N and Palmer, LJ and Wanner, C and Drechsler, C and Hoffmann, MM and Fowk},
doi = {10.1136/bmj.d548},
journal = {British Medical Journal},
title = {Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data},
url = {http://dx.doi.org/10.1136/bmj.d548},
volume = {342},
year = {2011}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Objective To use genetic variants as unconfounded proxies of C reactive protein concentration to study its causal role in coronary heart disease.Design Mendelian randomisation meta-analysis of individual participant data from 47 epidemiological studies in 15 countries.Participants 194 418 participants, including 46 557 patients with prevalent or incident coronary heart disease. Information was available on four CRP gene tagging single nucleotide polymorphisms (rs3093077, rs1205, rs1130864, rs1800947), concentration of C reactive protein, and levels of other risk factors.Main outcome measures Risk ratios for coronary heart disease associated with genetically raised C reactive protein versus risk ratios with equivalent differences in C reactive protein concentration itself, adjusted for conventional risk factors and variability in risk factor levels within individuals.Results CRP variants were each associated with up to 30% per allele difference in concentration of C reactive protein (P<10−34) and were unrelated to other risk factors. Risk ratios for coronary heart disease per additional copy of an allele associated with raised C reactive protein were 0.93 (95% confidence interval 0.87 to 1.00) for rs3093077; 1.00 (0.98 to 1.02) for rs1205; 0.98 (0.96 to 1.00) for rs1130864; and 0.99 (0.94 to 1.03) for rs1800947. In a combined analysis, the risk ratio for coronary heart disease was 1.00 (0.90 to 1.13) per 1 SD higher genetically raised natural log (ln) concentration of C reactive protein. The genetic findings were discordant with the risk ratio observed for coronary heart disease of 1.33 (1.23 to 1.43) per 1 SD higher circulating ln concentration of C reactive protein in prospective studies (P=0.001 for difference).Conclusion Human genetic data indicate that C reactive protein concentration itself is unlikely to be even a modest causal factor in coronary heart disease.
AU - Wensley,F
AU - Gao,P
AU - Burgess,S
AU - Kaptoge,S
AU - Di,Angelantonio E
AU - Shah,T
AU - Engert,JC
AU - Clarke,R
AU - Davey-Smith,G
AU - Nordestgaard,BG
AU - Saleheen,D
AU - Samani,NJ
AU - Sandhu,M
AU - Anand,S
AU - Pepys,MB
AU - Smeeth,L
AU - Whittaker,J
AU - Casas,JP
AU - Thompson,SG
AU - Hingorani,AD
AU - Danesh,J
AU - Eiriksdottir,G
AU - Harris,TB
AU - Launer,LJ
AU - Gudnason,V
AU - Folsom,AR
AU - Andrews,G
AU - Ballantyne,CM
AU - Samani,NJ
AU - Hall,AS
AU - Braund,PS
AU - Balmforth,AJ
AU - Whincup,PH
AU - Morris,R
AU - Lawlor,DA
AU - Lowe,GDO
AU - Timpson,N
AU - Ebrahim,S
AU - Ben-Shlomo,Y
AU - Davey-Smith,G
AU - Timpson,N
AU - Nordestgaard,BG
AU - Tybjaerg-Hansen,A
AU - Zacho,J
AU - Brown,M
AU - Sandhu,M
AU - Ricketts,SL
AU - Ashford,S
AU - Lange,L
AU - Reiner,A
AU - Cushman,M
AU - Tracy,R
AU - Wu,C
AU - Ge,J
AU - Zou,Y
AU - Sun,A
AU - Hung,J
AU - McQuillan,B
AU - Thompson,P
AU - Beilby,J
AU - Warrington,N
AU - Palmer,LJ
AU - Wanner,C
AU - Drechsler,C
AU - Hoffmann,MM
AU - Fowkes,FGR
AU - Lowe,GDO
AU - Tzoulaki,I
AU - Kumari,M
AU - Miller,M
AU - Marmot,M
AU - Onland-Moret,C
AU - van,der Schouw YT
AU - Boer,JM
AU - Wijmenga,C
AU - Ricketts,SL
AU - Ashford,S
AU - Sandhu,M
AU - Khaw,K-T
AU - Vasan,RS
AU - Schnabel,RB
AU - Yamamoto,JF
AU - Benjamin,EJ
AU - Schunkert,H
AU - Erdmann,J
AU - Koenig,IR
AU - Hengstenberg,C
AU - Chiodini,B
AU - Franzosi,MG
AU - Pietri,S
AU - Gori,F
AU - Rudock,M
AU - Liu,Y
AU - Lohman,K
AU - Harris,TB
AU - Humphries,SE
AU - Hamsten,A
AU - Norman,PE
AU - Hankey,GJ
AU - Jamrozik,K
AU - Palmer,LJ
AU - Rimm,EB
AU - Pai,JK
AU - Psaty,BM
AU - Heckbert,SR
AU - Bis,JC
AU - Yusuf,S
AU - Anand,S
AU - Engert,JC
AU - Xie,C
AU - Collins,R
AU - Clarke,R
AU - Bennett,D
AU - Kooner,J
AU - Chambers,J
AU - Elliott,P
AU - Maerz,W
AU - Kleber,ME
AU - Boehm,BO
AU - Winkelmann,BR
AU - Melander,O
AU - Berglund,G
AU - Koenig,W
AU - Thorand,B
AU - Baumert,J
AU - Peters,A
AU - Rimm,EB
AU - Manson,J
AU - Pai,JK
AU - Humphries,SE
AU - Cooper,JA
AU - Talmud,PJ
AU - Ladenvall,P
AU - Johansson,L
AU - Jansson,J-H
AU - Hallmans,G
AU - Reilly,MP
AU - Qu,L
AU - Li,M
AU - Rader,DJ
AU - Watkins,H
AU - Clarke,R
AU - Hopewell,J
AU - Saleheen,D
AU - Danesh,J
AU - Frossard,P
AU - Sattar,N
AU - Robertson,M
AU - Shepherd,J
AU - Schaefer,E
AU - Hofman,A
AU - Witteman,JCM
AU - Kardys,I
AU - Dehghan,A
AU - de,Faire U
AU - Bennet,A
AU - Gigante,B
AU - Leander,K
AU - Ben-Shlomo,Y
AU - Davey-Smith,G
AU - Timpson,N
AU - Peters,B
AU - Maitland-van,der Zee AH
AU - de,Boer A
AU - Klungel,O
AU - Reiner,A
AU - Manson,J
AU - Greenland,P
AU - Dai,J
AU - Liu,S
AU - Kumari,M
AU - Brunner,E
AU - Kivimaki,M
AU - Marmot,M
AU - Sattar,N
AU - O'Reilly,D
AU - Ford,I
AU - Packard,CJ
DO - 10.1136/bmj.d548
PY - 2011///
SN - 1468-5833
TI - Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data
T2 - British Medical Journal
UR - http://dx.doi.org/10.1136/bmj.d548
UR - http://hdl.handle.net/10044/1/28717
VL - 342
ER -