Imperial College London

DrAbbasDehghan

Faculty of MedicineSchool of Public Health

Reader in Cardiometabolic Disease Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
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Location

 

157Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pattaro:2016:10.1038/ncomms10023,
author = {Pattaro, C and Teumer, A and Gorski, M and Chu, AY and Li, M and Mijatovic, V and Garnaas, M and Tin, A and Sorice, R and Li, Y and Taliun, D and Olden, M and Foster, M and Yang, Q and Chen, MH and Pers, TH and Johnson, AD and Ko, YA and Fuchsberger, C and Tayo, B and Nalls, M and Feitosa, MF and Isaacs, A and Dehghan, A and d'Adamo, P and Adeyemo, A and Dieffenbach, AK and Zonderman, AB and Nolte, IM and van, der Most PJ and Wright, AF and Shuldiner, AR and Morrison, AC and Hofman, A and Smith, AV and Dreisbach, AW and Franke, A and Uitterlinden, AG and Metspalu, A and Tonjes, A and Lupo, A and Robino, A and Johansson, Å and Demirkan, A and Kollerits, B and Freedman, BI and Ponte, B and Oostra, BA and Paulweber, B and Krämer, BK and Mitchell, BD and Buckley, BM and Peralta, CA and Hayward, C and Helmer, C and Rotimi, CN and Shaffer, CM and Müller, C and Sala, C and van, Duijn CM and Saint-Pierre, A and Ackermann, D and Shriner, D and Ruggiero, D and Toniolo, D and Lu, Y and Cusi, D an},
doi = {10.1038/ncomms10023},
journal = {Nat Commun},
title = {Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.},
url = {http://dx.doi.org/10.1038/ncomms10023},
volume = {7},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
AU - Pattaro,C
AU - Teumer,A
AU - Gorski,M
AU - Chu,AY
AU - Li,M
AU - Mijatovic,V
AU - Garnaas,M
AU - Tin,A
AU - Sorice,R
AU - Li,Y
AU - Taliun,D
AU - Olden,M
AU - Foster,M
AU - Yang,Q
AU - Chen,MH
AU - Pers,TH
AU - Johnson,AD
AU - Ko,YA
AU - Fuchsberger,C
AU - Tayo,B
AU - Nalls,M
AU - Feitosa,MF
AU - Isaacs,A
AU - Dehghan,A
AU - d'Adamo,P
AU - Adeyemo,A
AU - Dieffenbach,AK
AU - Zonderman,AB
AU - Nolte,IM
AU - van,der Most PJ
AU - Wright,AF
AU - Shuldiner,AR
AU - Morrison,AC
AU - Hofman,A
AU - Smith,AV
AU - Dreisbach,AW
AU - Franke,A
AU - Uitterlinden,AG
AU - Metspalu,A
AU - Tonjes,A
AU - Lupo,A
AU - Robino,A
AU - Johansson,Å
AU - Demirkan,A
AU - Kollerits,B
AU - Freedman,BI
AU - Ponte,B
AU - Oostra,BA
AU - Paulweber,B
AU - Krämer,BK
AU - Mitchell,BD
AU - Buckley,BM
AU - Peralta,CA
AU - Hayward,C
AU - Helmer,C
AU - Rotimi,CN
AU - Shaffer,CM
AU - Müller,C
AU - Sala,C
AU - van,Duijn CM
AU - Saint-Pierre,A
AU - Ackermann,D
AU - Shriner,D
AU - Ruggiero,D
AU - Toniolo,D
AU - Lu,Y
AU - Cusi,D
AU - Czamara,D
AU - Ellinghaus,D
AU - Siscovick,DS
AU - Ruderfer,D
AU - Gieger,C
AU - Grallert,H
AU - Rochtchina,E
AU - Atkinson,EJ
AU - Holliday,EG
AU - Boerwinkle,E
AU - Salvi,E
AU - Bottinger,EP
AU - Murgia,F
AU - Rivadeneira,F
AU - Ernst,F
AU - Kronenberg,F
AU - Hu,FB
AU - Navis,GJ
AU - Curhan,GC
AU - Ehret,GB
AU - Homuth,G
AU - Coassin,S
AU - Thun,GA
AU - Pistis,G
AU - Gambaro,G
AU - Malerba,G
AU - Montgomery,GW
AU - Eiriksdottir,G
AU - Jacobs,G
AU - Li,G
AU - Wichmann,HE
AU - Campbell,H
AU - Schmidt,H
AU - Wallaschofski,H
AU - Völzke,H
AU - Brenner,H
AU - Kroemer,HK
AU - Kramer,H
AU - Lin,H
AU - Mateo,Leach I
AU - Ford,I
AU - Guessous,I
AU - Rudan,I
AU - Prokopenko,I
AU - Borecki,I
AU - Heid,IM
AU - Kolcic,I
AU - Persico,I
AU - Jukema,JW
AU - Wilson,JF
AU - Felix,JF
AU - Divers,J
AU - Lambert,JC
AU - Stafford,JM
AU - Gaspoz,JM
AU - Smith,JA
AU - Faul,JD
AU - Wang,JJ
AU - Ding,J
AU - Hirschhorn,JN
AU - Attia,J
AU - Whitfield,JB
AU - Chalmers,J
AU - Viikari,J
AU - Coresh,J
AU - Denny,JC
AU - Karjalainen,J
AU - Fernandes,JK
AU - Endlich,K
AU - Butterbach,K
AU - Keene,KL
AU - Lohman,K
AU - Portas,L
AU - Launer,LJ
AU - Lyytikäinen,LP
AU - Yengo,L
AU - Franke,L
AU - Ferrucci,L
AU - Rose,LM
AU - Kedenko,L
AU - Rao,M
AU - Struchalin,M
AU - Kleber,ME
AU - Cavalieri,M
AU - Haun,M
AU - Cornelis,MC
AU - Ciullo,M
AU - Pirastu,M
AU - de,Andrade M
AU - McEvoy,MA
AU - Woodward,M
AU - Adam,M
AU - Cocca,M
AU - Nauck,M
AU - Imboden,M
AU - Waldenberger,M
AU - Pruijm,M
AU - Metzger,M
AU - Stumvoll,M
AU - Evans,MK
AU - Sale,MM
AU - Kähönen,M
AU - Boban,M
AU - Bochud,M
AU - Rheinberger,M
AU - Verweij,N
AU - Bouatia-Naji,N
AU - Martin,NG
AU - Hastie,N
AU - Probst-Hensch,N
AU - Soranzo,N
AU - Devuyst,O R
DO - 10.1038/ncomms10023
PY - 2016///
TI - Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
T2 - Nat Commun
UR - http://dx.doi.org/10.1038/ncomms10023
UR - http://www.ncbi.nlm.nih.gov/pubmed/26831199
UR - http://hdl.handle.net/10044/1/29528
VL - 7
ER -