Imperial College London


Faculty of MedicineSchool of Public Health

Reader in Cardiometabolic Disease Epidemiology



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BibTex format

author = {Dhana, K and Nano, J and Ligthart, S and Peeters, A and Hofman, A and Nusselder, W and Dehghan, A and Franco, OH},
doi = {10.1371/journal.pmed.1002086},
journal = {PLoS Medicine},
title = {Obesity and Life Expectancy with and without Diabetes in Adults Aged 55 Years and Older in the Netherlands: A Prospective Cohort Study},
url = {},
volume = {13},
year = {2016}

RIS format (EndNote, RefMan)

AB - BackgroundOverweight and obesity are associated with increased risk of type 2 diabetes. Limited evidenceexists regarding the effect of excess weight on years lived with and without diabetes.We aimed to determine the association of overweight and obesity with the number of yearslived with and without diabetes in a middle-aged and elderly population.Methods and FindingsThe study included 6,499 individuals (3,656 women) aged 55 y and older from the population-basedRotterdam Study. We developed a multistate life table to calculate life expectancyfor individuals who were normal weight, overweight, and obese and the difference inyears lived with and without diabetes. For life table calculations, we used prevalence, incidencerate, and hazard ratios (HRs) for three transitions (healthy to diabetes, healthy todeath, and diabetes to death), stratifying by body mass index (BMI) at baseline and adjustingfor confounders. During a median follow-up of 11.1 y, we observed 697 incident diabetesevents and 2,192 overall deaths. Obesity was associated with an increased risk of developingdiabetes (HR: 2.13 [p < 0.001] for men and 3.54 [p < 0.001] for women). Overweightand obesity were not associated with mortality in men and women with or without diabetes.Total life expectancy remained unaffected by overweight and obesity. Nevertheless, menwith obesity aged 55 y and older lived 2.8 (95% CI −6.1 to −0.1) fewer y without diabetesthan normal weight individuals, whereas, for women, the difference between obese and normalweight counterparts was 4.7 (95% CI −9.0 to −0.6) y. Men and women with obesity lived2.8 (95% CI 0.6 to 6.2) and 5.3 (95% CI 1.6 to 9.3) y longer with diabetes, respectively, comparedto their normal weight counterparts. Since the implications of these findings could be limited to middle-aged and older white European populations, our results need confirmationin other populations.ConclusionsObesity in the middle aged and elderly is associated with
AU - Dhana,K
AU - Nano,J
AU - Ligthart,S
AU - Peeters,A
AU - Hofman,A
AU - Nusselder,W
AU - Dehghan,A
AU - Franco,OH
DO - 10.1371/journal.pmed.1002086
PY - 2016///
SN - 1549-1277
TI - Obesity and Life Expectancy with and without Diabetes in Adults Aged 55 Years and Older in the Netherlands: A Prospective Cohort Study
T2 - PLoS Medicine
UR -
UR -
VL - 13
ER -