Imperial College London

DrAbbasDehghan

Faculty of MedicineSchool of Public Health

Reader in Cardiometabolic Disease Epidemiology
 
 
 
//

Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
//

Location

 

157Norfolk PlaceSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Dehghan:2016:10.1371/journal.pone.0144997,
author = {Dehghan, A and Bis, JC and White, CC and Smith, AV and Morrison, AC and Cupples, LA and Trompet, S and Chasman, DI and Lumley, T and Voelker, U and Buckley, BM and Ding, J and Jensen, MK and Folsom, AR and Kritchevsky, SB and Girman, CJ and Ford, I and Doerr, M and Salomaa, V and Uitterlinden, AG and Eiriksdottir, G and Vasan, RS and Franceschini, N and Carty, CL and Virtamo, J and Demissie, S and Amouyel, P and Arveiler, D and Heckbert, SR and Ferrieres, J and Ducimetiere, P and Smith, NL and Wang, YA and Siscovick, DS and Rice, KM and Wiklund, P-G and Taylor, KD and Evans, A and Kee, F and Rotter, JI and Karvanen, J and Kuulasmaa, K and Heiss, G and Kraft, P and Launer, LJ and Hofman, A and Markus, MRP and Rose, LM and Silander, K and Wagner, P and Benjamin, EJ and Lohman, K and Stott, DJ and Rivadeneira, F and Harris, TB and Levy, D and Liu, Y and Rimm, EB and Jukema, JW and Voelzke, H and Ridker, PM and Blankenberg, S and Franco, OH and Gudnason, V and Psaty, BM and Boerwinkle, E a},
doi = {10.1371/journal.pone.0144997},
journal = {PLOS One},
title = {Genome-wide association study for incident myocardial infarction and coronary heart disease in prospective cohort studies: The CHARGE Consortium},
url = {http://dx.doi.org/10.1371/journal.pone.0144997},
volume = {11},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BackgroundData are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a prospective setting.MethodsWe performed a two-stage GWAS analysis of incident myocardial infarction (MI) and CHD in a total of 64,297 individuals (including 3898 MI cases, 5465 CHD cases). SNPs that passed an arbitrary threshold of 5×10−6 in Stage I were taken to Stage II for further discovery. Furthermore, in an analysis of prognosis, we studied whether known SNPs from former GWAS were associated with total mortality in individuals who experienced MI during follow-up.ResultsIn Stage I 15 loci passed the threshold of 5×10−6; 8 loci for MI and 8 loci for CHD, for which one locus overlapped and none were reported in previous GWAS meta-analyses. We took 60 SNPs representing these 15 loci to Stage II of discovery. Four SNPs near QKI showed nominally significant association with MI (p-value<8.8×10−3) and three exceeded the genome-wide significance threshold when Stage I and Stage II results were combined (top SNP rs6941513: p = 6.2×10−9). Despite excellent power, the 9p21 locus SNP (rs1333049) was only modestly associated with MI (HR = 1.09, p-value = 0.02) and marginally with CHD (HR = 1.06, p-value = 0.08). Among an inception cohort of those who experienced MI during follow-up, the risk allele of rs1333049 was associated with a decreased risk of subsequent mortality (HR = 0.90, p-value = 3.2×10−3).ConclusionsQKI represents a novel locus that may serve as a predictor of incident CHD in prospective studies. The association of the 9p21 locus both with increased risk of first myocardial infarction and longer survival after MI highlights the importance of study design in investigating genetic determinants of complex disorders.
AU - Dehghan,A
AU - Bis,JC
AU - White,CC
AU - Smith,AV
AU - Morrison,AC
AU - Cupples,LA
AU - Trompet,S
AU - Chasman,DI
AU - Lumley,T
AU - Voelker,U
AU - Buckley,BM
AU - Ding,J
AU - Jensen,MK
AU - Folsom,AR
AU - Kritchevsky,SB
AU - Girman,CJ
AU - Ford,I
AU - Doerr,M
AU - Salomaa,V
AU - Uitterlinden,AG
AU - Eiriksdottir,G
AU - Vasan,RS
AU - Franceschini,N
AU - Carty,CL
AU - Virtamo,J
AU - Demissie,S
AU - Amouyel,P
AU - Arveiler,D
AU - Heckbert,SR
AU - Ferrieres,J
AU - Ducimetiere,P
AU - Smith,NL
AU - Wang,YA
AU - Siscovick,DS
AU - Rice,KM
AU - Wiklund,P-G
AU - Taylor,KD
AU - Evans,A
AU - Kee,F
AU - Rotter,JI
AU - Karvanen,J
AU - Kuulasmaa,K
AU - Heiss,G
AU - Kraft,P
AU - Launer,LJ
AU - Hofman,A
AU - Markus,MRP
AU - Rose,LM
AU - Silander,K
AU - Wagner,P
AU - Benjamin,EJ
AU - Lohman,K
AU - Stott,DJ
AU - Rivadeneira,F
AU - Harris,TB
AU - Levy,D
AU - Liu,Y
AU - Rimm,EB
AU - Jukema,JW
AU - Voelzke,H
AU - Ridker,PM
AU - Blankenberg,S
AU - Franco,OH
AU - Gudnason,V
AU - Psaty,BM
AU - Boerwinkle,E
AU - O'Donnell,CJ
DO - 10.1371/journal.pone.0144997
PY - 2016///
SN - 1932-6203
TI - Genome-wide association study for incident myocardial infarction and coronary heart disease in prospective cohort studies: The CHARGE Consortium
T2 - PLOS One
UR - http://dx.doi.org/10.1371/journal.pone.0144997
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000371990100004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/52880
VL - 11
ER -