Imperial College London

DrAbbasDehghan

Faculty of MedicineSchool of Public Health

Reader in Cardiometabolic Disease Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
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Location

 

157Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yang:2010:10.1161/CIRCGENETICS.109.934455,
author = {Yang, Q and Köttgen, A and Dehghan, A and Smith, AV and Glazer, NL and Chen, M-H and Chasman, DI and Aspelund, T and Eiriksdottir, G and Harris, TB and Launer, L and Nalls, M and Hernandez, D and Arking, DE and Boerwinkle, E and Grove, ML and Li, M and Linda, Kao WH and Chonchol, M and Haritunians, T and Li, G and Lumley, T and Psaty, BM and Shlipak, M and Hwang, S-J and Larson, MG and O'Donnell, CJ and Upadhyay, A and van, Duijn CM and Hofman, A and Rivadeneira, F and Stricker, B and Uitterlinden, AG and Paré, G and Parker, AN and Ridker, PM and Siscovick, DS and Gudnason, V and Witteman, JC and Fox, CS and Coresh, J},
doi = {10.1161/CIRCGENETICS.109.934455},
journal = {Circ Cardiovasc Genet},
pages = {523--530},
title = {Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.},
url = {http://dx.doi.org/10.1161/CIRCGENETICS.109.934455},
volume = {3},
year = {2010}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BACKGROUND: Elevated serum urate levels can lead to gout and are associated with cardiovascular risk factors. We performed a genome-wide association study to search for genetic susceptibility loci for serum urate and gout and investigated the causal nature of the associations of serum urate with gout and selected cardiovascular risk factors and coronary heart disease (CHD). METHODS AND RESULTS: Meta-analyses of genome-wide association studies (GWAS) were performed in 5 population-based cohorts of the Cohorts for Heart and Aging Research in Genome Epidemiology consortium for serum urate and gout in 28 283 white participants. The effect of the most significant single-nucleotide polymorphism at all genome-wide significant loci on serum urate was added to create a genetic urate score. Findings were replicated in the Women's Genome Health Study (n=22 054). Single-nucleotide polymorphisms at 8 genetic loci achieved genome-wide significance with serum urate levels (P=4×10(-8) to 2×10(-242) in SLC22A11, GCKR, R3HDM2-INHBC region, RREB1, PDZK1, SLC2A9, ABCG2, and SLC17A1). Only 2 loci (SLC2A9, ABCG2) showed genome-wide significant association with gout. The genetic urate score was strongly associated with serum urate and gout (odds ratio, 12.4 per 100 μmol/L; P=3×10(-39)) but not with blood pressure, glucose, estimated glomerular filtration rate, chronic kidney disease, or CHD. The lack of association between the genetic score and the latter phenotypes also was observed in the Women's Genome Health Study. CONCLUSIONS: The genetic urate score analysis suggested a causal relationship between serum urate and gout but did not provide evidence for one between serum urate and cardiovascular risk factors and CHD.
AU - Yang,Q
AU - Köttgen,A
AU - Dehghan,A
AU - Smith,AV
AU - Glazer,NL
AU - Chen,M-H
AU - Chasman,DI
AU - Aspelund,T
AU - Eiriksdottir,G
AU - Harris,TB
AU - Launer,L
AU - Nalls,M
AU - Hernandez,D
AU - Arking,DE
AU - Boerwinkle,E
AU - Grove,ML
AU - Li,M
AU - Linda,Kao WH
AU - Chonchol,M
AU - Haritunians,T
AU - Li,G
AU - Lumley,T
AU - Psaty,BM
AU - Shlipak,M
AU - Hwang,S-J
AU - Larson,MG
AU - O'Donnell,CJ
AU - Upadhyay,A
AU - van,Duijn CM
AU - Hofman,A
AU - Rivadeneira,F
AU - Stricker,B
AU - Uitterlinden,AG
AU - Paré,G
AU - Parker,AN
AU - Ridker,PM
AU - Siscovick,DS
AU - Gudnason,V
AU - Witteman,JC
AU - Fox,CS
AU - Coresh,J
DO - 10.1161/CIRCGENETICS.109.934455
EP - 530
PY - 2010///
SP - 523
TI - Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.
T2 - Circ Cardiovasc Genet
UR - http://dx.doi.org/10.1161/CIRCGENETICS.109.934455
UR - https://www.ncbi.nlm.nih.gov/pubmed/20884846
VL - 3
ER -