Imperial College London

DrAbbasDehghan

Faculty of MedicineSchool of Public Health

Reader in Cardiometabolic Disease Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
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Location

 

157Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pazoki:2019:10.1161/CIR.0000000000000646,
author = {Pazoki, R and Dehghan, A and Evangelou, E and Warren, H and Gao, H and Caulfield, M and Elliott, P and Tzoulaki, I and Tzoulaki, I and Dehghan, A and Pazoki, R and Evangelou, E and Elliott, P and Gao, H},
doi = {10.1161/CIR.0000000000000646},
journal = {Circulation},
pages = {E2--E2},
title = {Correction to: Genetic predisposition to high blood pressure and lifestyle factors: associations with midlife blood pressure levels and cardiovascular events},
url = {http://dx.doi.org/10.1161/CIR.0000000000000646},
volume = {139},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Background: High blood pressure (BP) is a major risk factor for cardiovascular diseases (CVDs), the leading cause of mortality worldwide. Both heritable and lifestyle risk factors contribute to elevated BP levels. We aimed to investigate the extent to which lifestyle factors could offset the effect of an adverse BP genetic profile and its effect on CVD risk.Methods: We constructed a genetic risk score for high BP by using 314 published BP loci in 277 005 individuals without previous CVD from the UK Biobank study, a prospective cohort of individuals aged 40 to 69 years, with a median of 6.11 years of follow-up. We scored participants according to their lifestyle factors including body mass index, healthy diet, sedentary lifestyle, alcohol consumption, smoking, and urinary sodium excretion levels measured at recruitment. We examined the association between tertiles of genetic risk and tertiles of lifestyle score with BP levels and incident CVD by using linear regression and Cox regression models, respectively.Results: Healthy lifestyle score was strongly associated with BP (P<10–320) for systolic and diastolic BP and CVD events regardless of the underlying BP genetic risk. Participants with a favorable in comparison with an unfavorable lifestyle (bottom versus top tertile lifestyle score) had 3.6, 3.5, and 3.6 mm Hg lower systolic BP in low, middle, and high genetic risk groups, respectively (P for interaction=0.0006). Similarly, favorable in comparison with unfavorable lifestyle showed 30%, 31%, and 33% lower risk of CVD among participants in low, middle, and high genetic risk groups, respectively (P for interaction=0.99).Conclusions: Our data further support population-wide efforts to lower BP in the population via lifestyle modification. The advantages and disadvantages of disclosing genetic predisposition to high BP for risk stratification needs careful evaluation.
AU - Pazoki,R
AU - Dehghan,A
AU - Evangelou,E
AU - Warren,H
AU - Gao,H
AU - Caulfield,M
AU - Elliott,P
AU - Tzoulaki,I
AU - Tzoulaki,I
AU - Dehghan,A
AU - Pazoki,R
AU - Evangelou,E
AU - Elliott,P
AU - Gao,H
DO - 10.1161/CIR.0000000000000646
EP - 2
PY - 2019///
SN - 0009-7322
SP - 2
TI - Correction to: Genetic predisposition to high blood pressure and lifestyle factors: associations with midlife blood pressure levels and cardiovascular events
T2 - Circulation
UR - http://dx.doi.org/10.1161/CIR.0000000000000646
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000459428700002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/54016
VL - 139
ER -