Imperial College London

DrAbbasDehghan

Faculty of MedicineSchool of Public Health

Reader in Cardiometabolic Disease Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
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Location

 

157Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Aslibekyan:2018:10.1001/jamacardio.2018.0510,
author = {Aslibekyan, S and Agha, G and Colicino, E and Do, AN and Lahti, J and Ligthart, S and Marioni, RE and Marzi, C and Mendelson, MM and Tanaka, T and Wielscher, M and Absher, DM and Ferrucci, L and Franco, OH and Gieger, C and Grallert, H and Hernandez, D and Huan, T and Iurato, S and Joehanes, R and Just, AC and Kunze, S and Lin, H and Liu, C and Meigs, JB and van, Meurs JBJ and Moore, AZ and Peters, A and Prokisch, H and Raikkonen, K and Rathmann, W and Roden, M and Schramm, K and Schwartz, JD and Starr, JM and Uitterlinden, AG and Vokonas, P and Waldenberger, M and Yao, C and Zhi, D and Baccarelli, AA and Bandinelli, S and Deary, IJ and Dehghan, A and Eriksson, J and Herder, C and Jarvelin, M-R and Levy, D and Arnett, DK},
doi = {10.1001/jamacardio.2018.0510},
journal = {JAMA CARDIOLOGY},
pages = {463--472},
title = {Association of methylation signals with incident coronary heart disease in an epigenome-wide assessment of circulating tumor necrosis factor alpha},
url = {http://dx.doi.org/10.1001/jamacardio.2018.0510},
volume = {3},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Importance Tumor necrosis factor α (TNF-α) is a proinflammatory cytokine with manifold consequences for mammalian pathophysiology, including cardiovascular disease. A deeper understanding of TNF-α biology may enhance treatment precision.Objective To conduct an epigenome-wide analysis of blood-derived DNA methylation and TNF-α levels and to assess the clinical relevance of findings.Design, Setting, and Participants This meta-analysis assessed epigenome-wide associations in circulating TNF-α concentrations from 5 cohort studies and 1 interventional trial, with replication in 3 additional cohort studies. Follow-up analyses investigated associations of identified methylation loci with gene expression and incident coronary heart disease; this meta-analysis included 11461 participants who experienced 1895 coronary events.Exposures Circulating TNF-α concentration.Main Outcomes and Measures DNA methylation at approximately 450000 loci, neighboring DNA sequence variation, gene expression, and incident coronary heart disease.Results The discovery cohort included 4794 participants, and the replication study included 816 participants (overall mean [SD] age, 60.7 [8.5] years). In the discovery stage, circulating TNF-α levels were associated with methylation of 7 cytosine-phosphate-guanine (CpG) sites, 3 of which were located in or near DTX3L-PARP9 at cg00959259 (β [SE] = −0.01 [0.003]; P = 7.36 × 10−8), cg08122652 (β [SE] = −0.008 [0.002]; P = 2.24 × 10−7), and cg22930808(β [SE] = −0.01 [0.002]; P = 6.92 × 10−8); NLRC5 at cg16411857 (β [SE] = −0.01 [0.002]; P = 2.14 × 10−13) and cg07839457 (β [SE] = −0.02 [0.003]; P = 6.31 ×
AU - Aslibekyan,S
AU - Agha,G
AU - Colicino,E
AU - Do,AN
AU - Lahti,J
AU - Ligthart,S
AU - Marioni,RE
AU - Marzi,C
AU - Mendelson,MM
AU - Tanaka,T
AU - Wielscher,M
AU - Absher,DM
AU - Ferrucci,L
AU - Franco,OH
AU - Gieger,C
AU - Grallert,H
AU - Hernandez,D
AU - Huan,T
AU - Iurato,S
AU - Joehanes,R
AU - Just,AC
AU - Kunze,S
AU - Lin,H
AU - Liu,C
AU - Meigs,JB
AU - van,Meurs JBJ
AU - Moore,AZ
AU - Peters,A
AU - Prokisch,H
AU - Raikkonen,K
AU - Rathmann,W
AU - Roden,M
AU - Schramm,K
AU - Schwartz,JD
AU - Starr,JM
AU - Uitterlinden,AG
AU - Vokonas,P
AU - Waldenberger,M
AU - Yao,C
AU - Zhi,D
AU - Baccarelli,AA
AU - Bandinelli,S
AU - Deary,IJ
AU - Dehghan,A
AU - Eriksson,J
AU - Herder,C
AU - Jarvelin,M-R
AU - Levy,D
AU - Arnett,DK
DO - 10.1001/jamacardio.2018.0510
EP - 472
PY - 2018///
SN - 2380-6583
SP - 463
TI - Association of methylation signals with incident coronary heart disease in an epigenome-wide assessment of circulating tumor necrosis factor alpha
T2 - JAMA CARDIOLOGY
UR - http://dx.doi.org/10.1001/jamacardio.2018.0510
UR - http://hdl.handle.net/10044/1/61517
VL - 3
ER -