Imperial College London
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ProfessorAbbasDehghan

Faculty of Medicine, School of Public Health

Professor in Molecular Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ward-Caviness:2018:10.1182/blood-2018-02-831347,
author = {Ward-Caviness, CK and Huffman, JE and Everett, K and Germain, M and van, Dongen J and Hill, WD and Jhun, MA and Brody, JA and Ghanbari, M and Du, L and Roetker, NS and de, Vries PS and Waldenberger, M and Gieger, C and Wolf, P and Prokisch, H and Koenig, W and O'Donnell, CJ and Levy, D and Liu, C and Truong, V and Wells, PS and Trégouët, D-A and Tang, W and Morrison, AC and Boerwinkle, E and Wiggins, KL and McKnight, B and Guo, X and Psaty, BM and Sotoodenia, N and Boomsma, DI and Willemsen, G and Ligthart, L and Deary, IJ and Zhao, W and Ware, EB and Kardia, SLR and Van, Meurs JBJ and Uitterlinden, AG and Franco, OH and Eriksson, P and Franco-Cereceda, A and Pankow, JS and Johnson, AD and Gagnon, F and Morange, P-E and de, Geus EJC and Starr, JM and Smith, JA and Dehghan, A and Björck, HM and Smith, NL and Peters, A},
doi = {10.1182/blood-2018-02-831347},
journal = {Blood},
pages = {1842--1850},
title = {DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis.},
url = {http://dx.doi.org/10.1182/blood-2018-02-831347},
volume = {132},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Many hemostatic factors are associated with age and age-related diseases; however, much remains unknown about the biological mechanisms linking aging and hemostatic factors. DNA methylation is a novel means by which to assess epigenetic aging, which is a measure of age and the aging processes as determined by altered epigenetic states. We used a meta-analysis approach to examine the association between measures of epigenetic aging and hemostatic factors, as well as a clotting time measure. For fibrinogen, we performed European and African ancestry-specific meta-analyses which were then combined via a random effects meta-analysis. For all other measures we could not estimate ancestry-specific effects and used a single fixed effects meta-analysis. We found that 1-year higher extrinsic epigenetic age as compared with chronological age was associated with higher fibrinogen (0.004 g/L/y; 95% confidence interval, 0.001-0.007; P = .01) and plasminogen activator inhibitor 1 (PAI-1; 0.13 U/mL/y; 95% confidence interval, 0.07-0.20; P = 6.6 × 10-5) concentrations, as well as lower activated partial thromboplastin time, a measure of clotting time. We replicated PAI-1 associations using an independent cohort. To further elucidate potential functional mechanisms, we associated epigenetic aging with expression levels of the PAI-1 protein encoding gene (SERPINE1) and the 3 fibrinogen subunit-encoding genes (FGA, FGG, and FGB) in both peripheral blood and aorta intima-media samples. We observed associations between accelerated epigenetic aging and transcription of FGG in both tissues. Collectively, our results indicate that accelerated epigenetic aging is associated with a procoagulation hemostatic profile, and that epigenetic aging may regulate hemostasis in part via gene transcription.
AU  - Ward-Caviness,CK
AU  - Huffman,JE
AU  - Everett,K
AU  - Germain,M
AU  - van,Dongen J
AU  - Hill,WD
AU  - Jhun,MA
AU  - Brody,JA
AU  - Ghanbari,M
AU  - Du,L
AU  - Roetker,NS
AU  - de,Vries PS
AU  - Waldenberger,M
AU  - Gieger,C
AU  - Wolf,P
AU  - Prokisch,H
AU  - Koenig,W
AU  - O'Donnell,CJ
AU  - Levy,D
AU  - Liu,C
AU  - Truong,V
AU  - Wells,PS
AU  - Trégouët,D-A
AU  - Tang,W
AU  - Morrison,AC
AU  - Boerwinkle,E
AU  - Wiggins,KL
AU  - McKnight,B
AU  - Guo,X
AU  - Psaty,BM
AU  - Sotoodenia,N
AU  - Boomsma,DI
AU  - Willemsen,G
AU  - Ligthart,L
AU  - Deary,IJ
AU  - Zhao,W
AU  - Ware,EB
AU  - Kardia,SLR
AU  - Van,Meurs JBJ
AU  - Uitterlinden,AG
AU  - Franco,OH
AU  - Eriksson,P
AU  - Franco-Cereceda,A
AU  - Pankow,JS
AU  - Johnson,AD
AU  - Gagnon,F
AU  - Morange,P-E
AU  - de,Geus EJC
AU  - Starr,JM
AU  - Smith,JA
AU  - Dehghan,A
AU  - Björck,HM
AU  - Smith,NL
AU  - Peters,A
DO  - 10.1182/blood-2018-02-831347
EP  - 1850
PY  - 2018///
SP  - 1842
TI  - DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis.
T2  - Blood
UR  - http://dx.doi.org/10.1182/blood-2018-02-831347
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30042098
VL  - 132
ER  -
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