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@article{van:2020:10.1136/bmjdrc-2020-001529,
author = {van, Herpt TTW and Ligthart, S and Leening, MJG and van, Hoek M and Lieverse, AG and Ikram, MA and Sijbrands, EJG and Dehghan, A and Kavousi, M},
doi = {10.1136/bmjdrc-2020-001529},
journal = {BMJ Open Diabetes Res Care},
title = {Lifetime risk to progress from pre-diabetes to type 2 diabetes among women and men: comparison between American Diabetes Association and World Health Organization diagnostic criteria.},
url = {http://dx.doi.org/10.1136/bmjdrc-2020-001529},
volume = {8},
year = {2020}
}

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TY  - JOUR
AB  - INTRODUCTION: Pre-diabetes, a status conferring high risk of overt diabetes, is defined differently by the American Diabetes Association (ADA) and the WHO. We investigated the impact of applying definitions of pre-diabetes on lifetime risk of diabetes in women and men from the general population. RESEARCH DESIGN AND METHODS: We used data from 8844 women without diabetes and men aged ≥45 years from the prospective population-based Rotterdam Study in the Netherlands. In both gender groups, we calculated pre-diabetes prevalence according to ADA and WHO criteria and estimated the 10-year and lifetime risk to progress to overt diabetes with adjustment for competing risk of death. RESULTS: Out of 8844 individuals, pre-diabetes was identified in 3492 individuals (prevalence 40%, 95% CI 38% to 41%) according to ADA and 1382 individuals (prevalence 16%, 95% CI 15% to 16%) according to WHO criteria. In both women and men and each age category, ADA prevalence estimates doubled WHO-defined pre-diabetes. For women and men aged 45 years having ADA-defined pre-diabetes, the 10-year risk of diabetes was 14.2% (95% CI 6.0% to 22.5%) and 9.2% (95% CI 3.4% to 15.0%) compared with 23.2% (95% CI 6.8% to 39.6%) and 24.6% (95% CI 8.4% to 40.8%) in women and men with WHO-defined pre-diabetes. At age 45 years, the remaining lifetime risk to progress to overt diabetes was 57.5% (95% CI 51.8% to 63.2%) vs 80.2% (95% CI 74.1% to 86.3%) in women and 46.1% (95% CI 40.8% to 51.4%) vs 68.4% (95% CI 58.3% to 78.5%) in men with pre-diabetes according to ADA and WHO definitions, respectively. CONCLUSION: Prevalence of pre-diabetes differed considerably in both women and men when applying ADA and WHO pre-diabetes definitions. Women with pre-diabetes had higher lifetime risk to progress to diabetes. The lifetime risk of diabetes was lower in women and men with ADA-defined pre-diabetes as compared with WHO. Improvement of pre-diabetes definition considering appropriate sex-specific and
AU  - van,Herpt TTW
AU  - Ligthart,S
AU  - Leening,MJG
AU  - van,Hoek M
AU  - Lieverse,AG
AU  - Ikram,MA
AU  - Sijbrands,EJG
AU  - Dehghan,A
AU  - Kavousi,M
DO  - 10.1136/bmjdrc-2020-001529
PY  - 2020///
TI  - Lifetime risk to progress from pre-diabetes to type 2 diabetes among women and men: comparison between American Diabetes Association and World Health Organization diagnostic criteria.
T2  - BMJ Open Diabetes Res Care
UR  - http://dx.doi.org/10.1136/bmjdrc-2020-001529
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33214188
VL  - 8
ER  -

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