Imperial College London
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ProfessorAbbasDehghan

Faculty of Medicine, School of Public Health

Professor in Molecular Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{O'Farrell:2023:10.1038/s41598-023-47371-7,
author = {O'Farrell, F and Aleyakpo, B and Mustafa, R and Jiang, X and Pinto, RC and Elliott, P and Tzoulaki, I and Dehghan, A and Loh, SHY and Barclay, JW and Martins, LM and Pazoki, R},
doi = {10.1038/s41598-023-47371-7},
journal = {Scientific Reports},
title = {Evidence for involvement of the alcohol consumption WDPCP gene in lipid metabolism, and liver cirrhosis},
url = {http://dx.doi.org/10.1038/s41598-023-47371-7},
volume = {13},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Biological pathways between alcohol consumption and alcohol liver disease (ALD) are not fully understood. We selected genes with known effect on (1) alcohol consumption, (2) liver function, and (3) gene expression. Expression of the orthologs of these genes in Caenorhabditis elegans and Drosophila melanogaster was suppressed using mutations and/or RNA interference (RNAi). In humans, association analysis, pathway analysis, and Mendelian randomization analysis were performed to identify metabolic changes due to alcohol consumption. In C. elegans, we found a reduction in locomotion rate after exposure to ethanol for RNAi knockdown of ACTR1B and MAPT. In Drosophila, we observed (1) a change in sedative effect of ethanol for RNAi knockdown of WDPCP, TENM2, GPN1, ARPC1B, and SCN8A, (2) a reduction in ethanol consumption for RNAi knockdown of TENM2, (3) a reduction in triradylglycerols (TAG) levels for RNAi knockdown of WDPCP, TENM2, and GPN1. In human, we observed (1) a link between alcohol consumption and several metabolites including TAG, (2) an enrichment of the candidate (alcohol-associated) metabolites within the linoleic acid (LNA) and alpha-linolenic acid (ALA) metabolism pathways, (3) a causal link between gene expression of WDPCP to liver fibrosis and liver cirrhosis. Our results imply that WDPCP might be involved in ALD.
AU  - O'Farrell,F
AU  - Aleyakpo,B
AU  - Mustafa,R
AU  - Jiang,X
AU  - Pinto,RC
AU  - Elliott,P
AU  - Tzoulaki,I
AU  - Dehghan,A
AU  - Loh,SHY
AU  - Barclay,JW
AU  - Martins,LM
AU  - Pazoki,R
DO  - 10.1038/s41598-023-47371-7
PY  - 2023///
SN  - 2045-2322
TI  - Evidence for involvement of the alcohol consumption WDPCP gene in lipid metabolism, and liver cirrhosis
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-023-47371-7
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37996473
UR  - http://hdl.handle.net/10044/1/108096
VL  - 13
ER  -
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