Imperial College London

DrArmandoDel Rio Hernandez

Faculty of EngineeringDepartment of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 5187a.del-rio-hernandez

 
 
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Location

 

308Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

46 results found

Haining AWM, Lieberthal TJ, del Rio Hernandez A, 2016, Talin: a mechanosensitive molecule in healthand disease, The FASEB Journal, ISSN: 0892-6638

Talin is a ubiquitous, large focal adhesion protein that links intracellular networks with the extracellularmatrix (ECM)via its connection with the actin cytoskeleton andmembrane integrins. It is one of a handfulmoleculesthat can expose new recognition sites when undergoing force-induced mechanical unfolding, and it can bind andrecruit cytoskeletal proteins that are involved in mechanotransduction. Talin has attracted great interest in the fieldof mechanobiology because of its plasticity in undergoing conformational changes under force stimulation as wellas its cellular localization that bridges the cytoskeleton with the ECM. In addition to these roles in healthy cells, thedysregulation of talin activators can lead to disease states in which aberrant integrin activation and mechanotransductionprecipitate changes in cell spreading, migration, and survival. New data have implicated a role for talinin diseases that are highly regulated by mechanical cues. In this review, we present the current understanding of talinstructure, its relationship to binding partners, and its role in disease states.—Haining, A.W.M., Lieberthal,T. J., del R´─▒oHernandez, A. Talin: a mechanosensitive mol ´ ecule in health and disease.

JOURNAL ARTICLE

Roca-Cusachs P, del Rio A, Puklin-Faucher E, Gauthier NC, Biais N, Sheetz MPet al., 2013, Integrin-dependent force transmission to the extracellular matrix by alpha-actinin triggers adhesion maturation, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 110, Pages: E1361-E1370, ISSN: 0027-8424

JOURNAL ARTICLE

Roca-Cusachs P, Gauthier NC, del Rio A, Sheetz MPet al., 2009, Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 16245-16250, ISSN: 0027-8424

JOURNAL ARTICLE

del Rio A, Perez-Jimenez R, Liu R, Roca-Cusachs P, Fernandez JM, Sheetz MPet al., 2009, Stretching Single Talin Rod Molecules Activates Vinculin Binding, SCIENCE, Vol: 323, Pages: 638-641, ISSN: 0036-8075

JOURNAL ARTICLE

Del Rio A, Dutta K, Chavez J, Ubarretxena-Belandia I, Ghose Ret al., 2007, Solution structure and dynamics of the N-terminal cytosolic domain of rhomboid intramembrane protease from Pseudomonas aeruginosa: Insights into a functional role in intramembrane proteolysis, JOURNAL OF MOLECULAR BIOLOGY, Vol: 365, Pages: 109-122, ISSN: 0022-2836

JOURNAL ARTICLE

Del Rio A, Anand A, Ghose R, 2006, Detection of correlated dynamics on multiple timescales by measurement of the differential relaxation of zero- and double-quantum coherences involving sidechain methyl groups in proteins, JOURNAL OF MAGNETIC RESONANCE, Vol: 180, Pages: 1-17, ISSN: 1090-7807

JOURNAL ARTICLE

del Rio A, Coto B, Renuncio JAR, Pando Cet al., 2004, Vapor-liquid equilibria for the binary system 2,2-dimethylbutane plus 1,1-dimethylpropyl methyl ether (TAME) at 298.15, 318.15, and 338.15 K, FLUID PHASE EQUILIBRIA, Vol: 221, Pages: 1-6, ISSN: 0378-3812

JOURNAL ARTICLE

de Llano JJ, Segade L, Jimenez E, del Rio A, Renuncio JAR, Pando Cet al., 2003, Vapor-liquid equilibria for the binary system hexan-1-ol plus tert-butyl methyl ether (MTBE) at 298.15, 318.15, and 338.15 K, FLUID PHASE EQUILIBRIA, Vol: 208, Pages: 115-121, ISSN: 0378-3812

JOURNAL ARTICLE

Spuhl O, Arlt W, Hernandez AD, 2003, Prediction of thermodynamic material properties with the COSMO-RS continuum model, Meeting of the GVC Specialized committee on Thermal Dismantling of Gas, Publisher: WILEY-V C H VERLAG GMBH, Pages: 58-62, ISSN: 0009-286X

CONFERENCE PAPER

Segade L, de Llano JJ, Jimenez E, del Rio A, Pando C, Renuncio JARet al., 2003, Vapor-liquid equilibria of propan-1-ol+1,1-dimethylethyl methyl ether (MTBE) mixtures. Experimental results and modeling, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 5, Pages: 2858-2861, ISSN: 1463-9076

JOURNAL ARTICLE

del Rio A, Coto B, Pando C, Renuncio JARet al., 2002, Vapor-liquid equilibria and excess properties of octane+1,1-dimethylpropyl methyl ether (TAME) mixtures, FLUID PHASE EQUILIBRIA, Vol: 200, Pages: 41-51, ISSN: 0378-3812

JOURNAL ARTICLE

del Rio A, Coto B, Pando C, Renuncio JARet al., 2002, Vapor-liquid equilibria for the binary system hexane+1,1-dimethylpropyl methyl ether at 298.15, 308.15, 318.15, and 328.15 K, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, Vol: 41, Pages: 1364-1369, ISSN: 0888-5885

JOURNAL ARTICLE

del Rio A, Coto B, Pando C, Renuncio JARet al., 2001, Vapor-liquid equilibria for the binary systems decane+1, 1-dimethylethyl methyl ether (MTBE) and decane+1, 1-dimethylpropyl methyl ether (TAME) at 308.15, 318.15 and 328.15 K, FLUID PHASE EQUILIBRIA, Vol: 187, Pages: 299-310, ISSN: 0378-3812

JOURNAL ARTICLE

del Rio A, Coto B, Pando C, Renuncio JARet al., 2001, Vapor-liquid equilibria and excess properties of cyclohexane-1,1-dimethylpropyl methyl ether (TAME) mixtures, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, Vol: 40, Pages: 689-695, ISSN: 0888-5885

JOURNAL ARTICLE

del Rio A, Horstmann S, Renuncio JAR, Gmehling Jet al., 2001, Isothermal Vapor-Liquid Equilibrium and Excess Enthalpy Data for the Binary Systems Methyl tert-Butyl Ether + Cyclohexane and Ethyl tert-Butyl Ether + Cyclohexane, n-Hexane, and n-Heptane in a Temperature Range from 298.15 to 393.15 K., Journal of Chemical Engineering Data, Vol: 46, Pages: 1181-1187

Isothermal vapor−liquid equilibrium (VLE) and excess enthalpy (HE) data are reported for binary systems containing branched ethers and hydrocarbons. The vapor−liquid equilibrium data for methyl tert-butyl ether (MTBE) + cyclohexane at 308.15 K, for ethyl tert-butyl ether (ETBE) + cyclohexane, n-hexane + ethyl tert-butyl ether, and ethyl tert-butyl ether + n-heptane from 298.15 to 363.15 K were measured by means of a computer-controlled static apparatus. An isothermal flow calorimeter was used to obtain excess enthalpy data for the systems containing ethyl tert-butyl ether at 313.15 and 393.15 K. The experimental VLE and HE data were compared with the data of other authors and have been used simultaneously for the correlation of temperature-dependent UNIQUAC parameters.

JOURNAL ARTICLE

del Rio A, Coto R, Pando C, Renuncio JARet al., 1999, Vapour-liquid equilibria for the binary system cyclohexane-1,1-dimethylethyl methyl ether (MTBE) at 298.15, 308.15 and 318.15 K, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 1, Pages: 4995-4998, ISSN: 1463-9076

JOURNAL ARTICLE

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