Imperial College London

DrArmandoDel Rio Hernandez

Faculty of EngineeringDepartment of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 5187a.del-rio-hernandez

 
 
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Location

 

308Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cameron:2018:10.3390/ijms19103028,
author = {Cameron, W and Elijah, M and Del, Rio Hernandez A},
doi = {10.3390/ijms19103028},
journal = {International Journal of Molecular Sciences},
title = {Role of extracellular matrix in development and cancer progression},
url = {http://dx.doi.org/10.3390/ijms19103028},
volume = {19},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is constantly deposited, remodelled, and degraded during development until maturity to maintain tissue homeostasis. The ECM’s composition and organization are spatiotemporally regulated to control cell behaviour and differentiation, but dysregulation of ECM dynamics leads to the development of diseases such as cancer. The chemical cues presented by the ECM have been appreciated as key drivers for both development and cancer progression. However, the mechanical forces present due to the ECM have been largely ignored but recently recognized to play critical roles in disease progression and malignant cell behaviour. Here, we review the ways in which biophysical forces of the microenvironment influence biochemical regulation and cell phenotype during key stages of human development and cancer progression.
AU - Cameron,W
AU - Elijah,M
AU - Del,Rio Hernandez A
DO - 10.3390/ijms19103028
PY - 2018///
SN - 1422-0067
TI - Role of extracellular matrix in development and cancer progression
T2 - International Journal of Molecular Sciences
UR - http://dx.doi.org/10.3390/ijms19103028
UR - http://hdl.handle.net/10044/1/65160
VL - 19
ER -