Imperial College London

DrArmandoDel Rio Hernandez

Faculty of EngineeringDepartment of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 5187a.del-rio-hernandez

 
 
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Location

 

308Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rice:2019:10.3389/fonc.2019.00952,
author = {Rice, A and Del, Rio Hernandez A},
doi = {10.3389/fonc.2019.00952},
journal = {Frontiers in Oncology},
title = {The mutational landscape of pancreatic and liver cancer, as represented by circulating tumour DNA},
url = {http://dx.doi.org/10.3389/fonc.2019.00952},
volume = {9},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The mutational landscapes of pancreatic and liver cancer share many common genetic alterations which drive cancer progression.However, these mutations do not occur in all cases of these diseases, and this tumoural heterogeneity impedes diagnosis,prognosis and therapeutic development. One minimally invasive method for the evaluation of tumour mutations is the analysis ofcirculating tumour DNA (ctDNA), released through apoptosis, necrosis and active secretion by tumour cells into various body fluids.By observing mutations in those genes which promote transformation by controlling the cell cycle and oncogenic signallingpathways, a representation of the mutational profile of the tumour is revealed. The analysis of ctDNA is a promising technique forinvestigating these two gastrointestinal cancers, as many studies have reported on the accuracy of ctDNA assessment fordiagnosis and prognosis using a variety of techniques.
AU - Rice,A
AU - Del,Rio Hernandez A
DO - 10.3389/fonc.2019.00952
PY - 2019///
SN - 2234-943X
TI - The mutational landscape of pancreatic and liver cancer, as represented by circulating tumour DNA
T2 - Frontiers in Oncology
UR - http://dx.doi.org/10.3389/fonc.2019.00952
UR - http://hdl.handle.net/10044/1/73359
VL - 9
ER -