Imperial College London

DrArmandoDel Rio Hernandez

Faculty of EngineeringDepartment of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 5187a.del-rio-hernandez

 
 
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Location

 

308Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Haining:2016:10.1096/fj.201500080R,
author = {Haining, AWM and Lieberthal, TJ and del, Rio Hernandez A},
doi = {10.1096/fj.201500080R},
journal = {The FASEB Journal},
title = {Talin: a mechanosensitive molecule in healthand disease},
url = {http://dx.doi.org/10.1096/fj.201500080R},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Talin is a ubiquitous, large focal adhesion protein that links intracellular networks with the extracellularmatrix (ECM)via its connection with the actin cytoskeleton andmembrane integrins. It is one of a handfulmoleculesthat can expose new recognition sites when undergoing force-induced mechanical unfolding, and it can bind andrecruit cytoskeletal proteins that are involved in mechanotransduction. Talin has attracted great interest in the fieldof mechanobiology because of its plasticity in undergoing conformational changes under force stimulation as wellas its cellular localization that bridges the cytoskeleton with the ECM. In addition to these roles in healthy cells, thedysregulation of talin activators can lead to disease states in which aberrant integrin activation and mechanotransductionprecipitate changes in cell spreading, migration, and survival. New data have implicated a role for talinin diseases that are highly regulated by mechanical cues. In this review, we present the current understanding of talinstructure, its relationship to binding partners, and its role in disease states.—Haining, A.W.M., Lieberthal,T. J., del R´oHernandez, A. Talin: a mechanosensitive mol ´ ecule in health and disease.
AU - Haining,AWM
AU - Lieberthal,TJ
AU - del,Rio Hernandez A
DO - 10.1096/fj.201500080R
PY - 2016///
SN - 0892-6638
TI - Talin: a mechanosensitive molecule in healthand disease
T2 - The FASEB Journal
UR - http://dx.doi.org/10.1096/fj.201500080R
ER -