Imperial College London

DrArmandoDel Rio Hernandez

Faculty of EngineeringDepartment of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 5187a.del-rio-hernandez

 
 
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Location

 

308Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{von:2018:10.1038/s41563-017-0014-0,
author = {von, Erlach T and Bertazzo, S and Wozniak, MA and Horejs, C and Maynard, SA and Attwood, S and Robinson, BK and Autefage, H and Kallepitis, C and Del, Rio Hernandez A and Chen, CS and Goldoni, S and Stevens, MM},
doi = {10.1038/s41563-017-0014-0},
journal = {Nature Materials},
pages = {237--242},
title = {Cell geometry dependent changes in plasma membrane order direct stem cell signalling and fate},
url = {http://dx.doi.org/10.1038/s41563-017-0014-0},
volume = {17},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Cell size and shape affect cellular processes such as cell survival, growth and differentiation1,2,3,4, thus establishing cell geometry as a fundamental regulator of cell physiology. The contributions of the cytoskeleton, specifically actomyosin tension, to these effects have been described, but the exact biophysical mechanisms that translate changes in cell geometry to changes in cell behaviour remain mostly unresolved. Using a variety of innovative materials techniques, we demonstrate that the nanostructure and lipid assembly within the cell plasma membrane are regulated by cell geometry in a ligand-independent manner. These biophysical changes trigger signalling events involving the serine/threonine kinase Akt/protein kinase B (PKB) that direct cell-geometry-dependent mesenchymal stem cell differentiation. Our study defines a central regulatory role by plasma membrane ordered lipid raft microdomains in modulating stem cell differentiation with potential translational applications.
AU - von,Erlach T
AU - Bertazzo,S
AU - Wozniak,MA
AU - Horejs,C
AU - Maynard,SA
AU - Attwood,S
AU - Robinson,BK
AU - Autefage,H
AU - Kallepitis,C
AU - Del,Rio Hernandez A
AU - Chen,CS
AU - Goldoni,S
AU - Stevens,MM
DO - 10.1038/s41563-017-0014-0
EP - 242
PY - 2018///
SN - 1476-1122
SP - 237
TI - Cell geometry dependent changes in plasma membrane order direct stem cell signalling and fate
T2 - Nature Materials
UR - http://dx.doi.org/10.1038/s41563-017-0014-0
UR - http://hdl.handle.net/10044/1/57125
VL - 17
ER -