Imperial College London

DrArmandoDel Rio Hernandez

Faculty of EngineeringDepartment of Bioengineering

Senior Lecturer



+44 (0)20 7594 5187a.del-rio-hernandez




308Bessemer BuildingSouth Kensington Campus






BibTex format

author = {Del, Rio Hernandez AE and Matellan, C},
journal = {Scientific Reports},
title = {Cost-effective rapid prototyping and assembly of poly(methyl methacrylate)microfluidic devices.},
url = {},
volume = {8},
year = {2018}

RIS format (EndNote, RefMan)

AB - The difficulty in translating conventional microfluidics from laboratory prototypes to commercial products has shifted research efforts towards thermoplastic materials for their higher translational potential and amenability to industrial manufacturing. Here, we present an accessible method to fabricate and assemble polymethyl methacrylate (PMMA) microfluidic devices in a “mask-less” and cost-effective manner that can be applied to manufacture a wide range of designs due to its versatility. Laser micromachining offers high flexibility in channel dimensions and morphology by controlling the laser properties, while our two-step surface treatment based on exposure to acetone vapour and low-temperature annealing enables improvement of the surface quality without deformation of the device. Finally, we demonstrate a capillarity-driven adhesive delivery bonding method that can produce an effective seal between PMMA devices and a variety of substrates, including glass, silicon and LiNbO3. We illustrate the potential of this technique with two microfluidic devices, an H-filter and a droplet generator. The technique proposed here offers a low entry barrier for the rapid prototyping of thermoplastic microfluidics, enabling iterative design for laboratories without access to conventional microfabrication equipment.
AU - Del,Rio Hernandez AE
AU - Matellan,C
PY - 2018///
SN - 2045-2322
TI - Cost-effective rapid prototyping and assembly of poly(methyl methacrylate)microfluidic devices.
T2 - Scientific Reports
UR -
VL - 8
ER -