Imperial College London
Alternate

DrArmandoDel Rio Hernandez

Faculty of Engineering, Department of Bioengineering

Reader in Cellular and Molecular Mechanotransduction
 
 
 
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Contact

 

+44 (0)20 7594 5187a.del-rio-hernandez

 
 
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Location

 

308Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rice:2020:10.3390/cancers12020289,
author = {Rice, A and Cortes, Lopez JE and Lachowski, D and Oertle, P and Matellan, C and thorpe, S and Ghose, R and wang, H and lee, D and Plodinec, M and Del, Rio Hernandez A},
doi = {10.3390/cancers12020289},
journal = {Cancers},
title = {GPER activation inhibits cancer cell mechanotransduction and basement membrane invasion via RhoA},
url = {http://dx.doi.org/10.3390/cancers12020289},
volume = {12},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The invasive properties of cancer cells are intimately linked to their mechanical phenotype, which can be regulated by intracellular biochemical signalling. Cell contractility, induced by mechanotransduction of a stiff fibrotic matrix, and the epithelial–mesenchymal transition (EMT) promote invasion. Metastasis involves cells pushing through the basement membrane into the stroma—both of which are altered in composition with cancer progression. Agonists of the G protein-coupled oestrogen receptor (GPER), such as tamoxifen, have been largely used in the clinic, and interest in GPER, which is abundantly expressed in tissues, has greatly increased despite a lack of understanding regarding the mechanisms which promote its multiple effects. Here, we show that specific activation of GPER inhibits EMT, mechanotransduction and cell contractility in cancer cells via the GTPase Ras homolog family member A (RhoA). We further show that GPER activation inhibits invasion through an in vitro basement membrane mimic, similar in structure to the pancreatic basement membrane that we reveal as an asymmetric bilayer, which differs in composition between healthy and cancer patients.Keywords: cancer biomechanics; metastasis; G protein-coupled receptors; tumour microenvironment
AU  - Rice,A
AU  - Cortes,Lopez JE
AU  - Lachowski,D
AU  - Oertle,P
AU  - Matellan,C
AU  - thorpe,S
AU  - Ghose,R
AU  - wang,H
AU  - lee,D
AU  - Plodinec,M
AU  - Del,Rio Hernandez A
DO  - 10.3390/cancers12020289
PY  - 2020///
SN  - 2072-6694
TI  - GPER activation inhibits cancer cell mechanotransduction and basement membrane invasion via RhoA
T2  - Cancers
UR  - http://dx.doi.org/10.3390/cancers12020289
UR  - http://hdl.handle.net/10044/1/77009
VL  - 12
ER  -
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