Imperial College London
Portrait Picture

DrAndrewEdwards

Faculty of Medicine, Department of Infectious Disease

Director of Postgraduate Education & Senior Lecturer
 
 
 
//

Contact

 

a.edwards Website

 
 
//

Location

 

5.40AFlowers buildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Krishna:2018:10.1099/mic.0.000695,
author = {Krishna, A and Holden, M and Peacock, S and Edwards, A and Wigneshweraraj, S},
doi = {10.1099/mic.0.000695},
journal = {Microbiology},
pages = {1189--1195},
title = {Naturally occurring polymorphisms in the virulence regulator Rsp modulate Staphylococcus aureus survival in blood and antibiotic susceptibility},
url = {http://dx.doi.org/10.1099/mic.0.000695},
volume = {164},
year = {2018}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Nasal colonization by the pathogen Staphylococcus aureus is a risk factor for subsequent infection. Loss of function mutations in the gene encoding the virulence regulator Rsp are associated with the transition of S. aureus from a colonizing isolate to one that causes bacteraemia. Here, we report the identification of several novel activity-altering mutations in rsp detected in clinical isolates, including for the first time, mutations that enhance agr operon activity. We assessed how these mutations affected infection-relevant phenotypes and found loss and enhancement of function mutations to have contrasting effects on S. aureus survival in blood and antibiotic susceptibility. These findings add to the growing body of evidence that suggests S. aureus ‘trades off’ virulence for the acquisition of traits that benefit survival in the host, and indicates that infection severity and treatment options can be significantly affected by mutations in the virulence regulator rsp.
AU  - Krishna,A
AU  - Holden,M
AU  - Peacock,S
AU  - Edwards,A
AU  - Wigneshweraraj,S
DO  - 10.1099/mic.0.000695
EP  - 1195
PY  - 2018///
SN  - 1350-0872
SP  - 1189
TI  - Naturally occurring polymorphisms in the virulence regulator Rsp modulate Staphylococcus aureus survival in blood and antibiotic susceptibility
T2  - Microbiology
UR  - http://dx.doi.org/10.1099/mic.0.000695
UR  - http://hdl.handle.net/10044/1/62025
VL  - 164
ER  -
Download