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@article{Ledger:2017:10.1099/mic.0.000529,
author = {Ledger, EVK and Pader, V and Edwards, A},
doi = {10.1099/mic.0.000529},
journal = {Microbiology},
pages = {1502--1508},
title = {Enterococcus faecalis and pathogenic streptococci inactivate daptomycin by releasing phospholipids},
url = {http://dx.doi.org/10.1099/mic.0.000529},
volume = {163},
year = {2017}
}

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TY  - JOUR
AB  - Daptomycin is a lipopeptide antibiotic with activity against Gram-positive bacteria. We showed previously that Staphylococcusaureus can survive daptomycin exposure by releasing membrane phospholipids that inactivate the antibiotic. To determinewhether other pathogens possess this defence mechanism, phospholipid release and daptomycin activity were measuredafter incubation of Staphylococcus epidermidis, group A or B streptococci, Streptococcus gordonii or Enterococcus faecalis withthe antibiotic. All bacteria released phospholipids in response to daptomycin, which resulted in at least partial inactivation ofthe antibiotic. However, E. faecalis showed the highest levels of lipid release and daptomycin inactivation. As shownpreviously for S. aureus, phospholipid release by E. faecalis was inhibited by the lipid biosynthesis inhibitor platensimycin. Inconclusion, several pathogenic Gram-positive bacteria, including E. faecalis, inactivate daptomycin by releasing phospholipids,which may contribute to the failure of daptomycin to resolve infections caused by these pathogens.
AU  - Ledger,EVK
AU  - Pader,V
AU  - Edwards,A
DO  - 10.1099/mic.0.000529
EP  - 1508
PY  - 2017///
SN  - 1350-0872
SP  - 1502
TI  - Enterococcus faecalis and pathogenic streptococci inactivate daptomycin by releasing phospholipids
T2  - Microbiology
UR  - http://dx.doi.org/10.1099/mic.0.000529
UR  - http://hdl.handle.net/10044/1/50451
VL  - 163
ER  -

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