Imperial College London
Portrait Picture

Professor Alan Fenwick OBE

Faculty of Medicine, School of Public Health

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 7594 3418a.fenwick Website

 
 
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Location

 

G30Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Knowles:2017:10.1371/journal.pntd.0005599,
author = {Knowles, SCL and Sturrock, HJW and Turner, H and Whitton, JM and Gower, CM and Jemu, S and Phillips, AE and Meite, A and Thomas, B and Kollie, K and Thomas, C and Rebollo, MP and Styles, B and Clements, M and Fenwick, A and Harrison, WE and Fleming, FM},
doi = {10.1371/journal.pntd.0005599},
journal = {PLOS Neglected Tropical Diseases},
title = {Optimising cluster survey design for planning schistosomiasis preventive chemotherapy},
url = {http://dx.doi.org/10.1371/journal.pntd.0005599},
volume = {11},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThe cornerstone of current schistosomiasis control programmes is delivery of praziquantel to at-risk populations. Such preventive chemotherapy requires accurate information on the geographic distribution of infection, yet the performance of alternative survey designs for estimating prevalence and converting this into treatment decisions has not been thoroughly evaluated.Methodology/Principal findingsWe used baseline schistosomiasis mapping surveys from three countries (Malawi, Côte d’Ivoire and Liberia) to generate spatially realistic gold standard datasets, against which we tested alternative two-stage cluster survey designs. We assessed how sampling different numbers of schools per district (2–20) and children per school (10–50) influences the accuracy of prevalence estimates and treatment class assignment, and we compared survey cost-efficiency using data from Malawi. Due to the focal nature of schistosomiasis, up to 53% simulated surveys involving 2–5 schools per district failed to detect schistosomiasis in low endemicity areas (1–10% prevalence). Increasing the number of schools surveyed per district improved treatment class assignment far more than increasing the number of children sampled per school. For Malawi, surveys of 15 schools per district and 20–30 children per school reliably detected endemic schistosomiasis and maximised cost-efficiency. In sensitivity analyses where treatment costs and the country considered were varied, optimal survey size was remarkably consistent, with cost-efficiency maximised at 15–20 schools per district.Conclusions/SignificanceAmong two-stage cluster surveys for schistosomiasis, our simulations indicated that surveying 15–20 schools per district and 20–30 children per school optimised cost-efficiency and minimised the risk of under-treatment, with surveys involving more schools of greater cost-efficiency as treatment costs rose.
AU  - Knowles,SCL
AU  - Sturrock,HJW
AU  - Turner,H
AU  - Whitton,JM
AU  - Gower,CM
AU  - Jemu,S
AU  - Phillips,AE
AU  - Meite,A
AU  - Thomas,B
AU  - Kollie,K
AU  - Thomas,C
AU  - Rebollo,MP
AU  - Styles,B
AU  - Clements,M
AU  - Fenwick,A
AU  - Harrison,WE
AU  - Fleming,FM
DO  - 10.1371/journal.pntd.0005599
PY  - 2017///
SN  - 1935-2735
TI  - Optimising cluster survey design for planning schistosomiasis preventive chemotherapy
T2  - PLOS Neglected Tropical Diseases
UR  - http://dx.doi.org/10.1371/journal.pntd.0005599
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000402927300046&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/48852
VL  - 11
ER  -
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