Imperial College London
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ProfessorAlainFilloux

Faculty of Natural Sciences, Department of Life Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 9651a.filloux Website CV

 
 
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Location

 

1.47Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lorenz:2019:10.1111/1462-2920.14468,
author = {Lorenz, A and Preusse, M and Bruchmann, S and Pawar, V and Grahl, N and Pils, MC and Nolan, LM and Filloux, A and Weiss, S and Haeussler, S},
doi = {10.1111/1462-2920.14468},
journal = {Environmental Microbiology},
pages = {883--897},
title = {Importance of flagella in acute and chronic Pseudomonas aeruginosa infections},
url = {http://dx.doi.org/10.1111/1462-2920.14468},
volume = {21},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Pseudomonas aeruginosa is an environmental microorganism and a causative agent of diverse acute and chronic, biofilmassociated infections. Advancing researchbased knowledge on its adaptation to conditions within the human host is bound to reveal novel strategies and targets for therapeutic intervention. Here, we investigated the traits that P. aeruginosa PA14 as well as a virulence attenuated ΔlasR mutant need to survive in selected murine infection models. Experimentally, the genetic programs that the bacteria use to adapt to biofilmassociated versus acute infections were dissected by passaging transposon mutant libraries through mouse lungs (acute) or mouse tumours (biofilminfection). Adaptive metabolic changes of P. aeruginosa were generally required during both infection processes. Counterselection against flagella expression was observed during acute lung infections. Obviously, avoidance of flagellamediated activation of host immunity is advantageous for the wildtype bacteria. For the ΔlasR mutant, loss of flagella did not confer a selective advantage. Apparently, other pathogenesis mechanisms are active in this virulence attenuated strain. In contrast, the infective process of P. aeruginosa in the chronic biofilm model apparently required expression of flagellin. Together, our findings imply that the host immune reactions against the infectious agent are very decisive for acuteness and duration of the infectious disease. They direct disease outcome.
AU  - Lorenz,A
AU  - Preusse,M
AU  - Bruchmann,S
AU  - Pawar,V
AU  - Grahl,N
AU  - Pils,MC
AU  - Nolan,LM
AU  - Filloux,A
AU  - Weiss,S
AU  - Haeussler,S
DO  - 10.1111/1462-2920.14468
EP  - 897
PY  - 2019///
SN  - 1462-2912
SP  - 883
TI  - Importance of flagella in acute and chronic Pseudomonas aeruginosa infections
T2  - Environmental Microbiology
UR  - http://dx.doi.org/10.1111/1462-2920.14468
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000461231300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://sfamjournals.onlinelibrary.wiley.com/doi/full/10.1111/1462-2920.14468
UR  - http://hdl.handle.net/10044/1/77234
VL  - 21
ER  -
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