Imperial College London
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ProfessorAlainFilloux

Faculty of Natural Sciences, Department of Life Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 9651a.filloux Website CV

 
 
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Location

 

1.47Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dortet:2018:10.1038/s41564-018-0109-7,
author = {Dortet, L and Lombardi, C and Cretin, F and Dessen, A and Filloux, A},
doi = {10.1038/s41564-018-0109-7},
journal = {Nature Microbiology},
pages = {378--386},
title = {Pore-forming activity of the Pseudomonas aeruginosa type III secretion system translocon alters the host epigenome},
url = {http://dx.doi.org/10.1038/s41564-018-0109-7},
volume = {3},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Recent studies highlight that bacterial pathogens can reprogram target cells by influencing epigenetic factors. The type III secretion system (T3SS) is a bacterial nanomachine that resembles a syringe on the bacterial surface. The T3SS ‘needle’ delivers translocon proteins into eukaryotic cell membranes, subsequently allowing injection of bacterial effectors into the cytosol. Here we show that Pseudomonas aeruginosa induces early T3SS-dependent dephosphorylation and deacetylation of histone H3 in eukaryotic cells. This is not triggered by any of the P. aeruginosa T3SS effectors, but results from the insertion of the PopB–PopD translocon into the membrane. This suggests that the P. aeruginosa translocon is a genuine T3SS effector acting as a pore-forming toxin. We visualized the translocon plugged into the host cell membrane after the bacterium has left the site of contact, and demonstrate that subsequent ion exchange through this pore is responsible for histone H3 modifications and host cell subversion.
AU  - Dortet,L
AU  - Lombardi,C
AU  - Cretin,F
AU  - Dessen,A
AU  - Filloux,A
DO  - 10.1038/s41564-018-0109-7
EP  - 386
PY  - 2018///
SN  - 2058-5276
SP  - 378
TI  - Pore-forming activity of the Pseudomonas aeruginosa type III secretion system translocon alters the host epigenome
T2  - Nature Microbiology
UR  - http://dx.doi.org/10.1038/s41564-018-0109-7
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000425846200019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/60544
VL  - 3
ER  -
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