Imperial College London

DrAdamFrampton

Faculty of MedicineDepartment of Surgery & Cancer

Honorary Clinical Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2125a.frampton

 
 
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Location

 

4005Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Research Areas

Molecular characterisation of Pancreatic Ductal Adenocarcinoma (PDAC) and pancreatic cystic tumours by:

  • Immunohistochemistry
  • microRNA and gene profiling of tissues, EUS-FNAs, blood and bile
  • Next-Generation Sequencing (RNA-Seq and small RNA-Seq)
  • Circulating Tumour Cells (CTCs)
  • In situ hybridisation (ISH)
  • Single-Cell Sequencing
  • Mouse-models of PDAC and metastasis assays

fig1

miRNA profiling of pancreatic malignant transformation from benign tumours

 

 

fig3

miRNAs target a tumour supressor gene network in PDAC

RESEARCH DETAILS CAN BE FOUND HERE

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Other research areas

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  • microRNAs in Breast, Colorectal, Ovarian and Neuroendocrine tumours
  • Molecular characterisation of Colorectal Liver Metastases after induction of Liver Hypertrophy

REVIEWER FOR FOLLOWING JOURNALS

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Collaborators

Prof. Oliver Strobel, University of Heidelberg, 2017

Prof Steve Pereira, Prof Steve Pereira, 2017

Dr Anguraj Sadanandam, Dr Anguraj Sadanandam, Institute of Cancer Research, 2017

Prof. Susan Galandiuk, University of Louisville, USA, 2016

Prof. Chris Wolfgang, Johns Hopkins, 2014

Prof. Andrea Frilling, Endocrine Surgery, 2013

Mr Nigel B. Jamieson, University of Glasgow, 2012

Dr Niccola Funel, University of Pisa, Italy, 2010

Dr Elisa Giovannetti, VU University Medical Center, Amsterdam, 2010

Guest Lectures

microRNAs in the diagnosis and prognosis of Pancreatic Cancer, Price Institute of Surgical Research, University of Louisville, KY, USA, 2016

Research Student Supervision

Fajardo,A, PhD student - Impact of preoperative manipulation for liver hypertrophy on liver regeneration, tumour growth and the transcriptome

Gall,TMH, MD (Res) - December 2015 - Predicting Disease Recurrence in Pancreatic Ductal Adenocarcinoma

Liu,D, PhD student - MIRABILE study

Malczewska,A, Circulating MicroRNAs in Small Bowel Neuroendocrine Tumors – a novel tool for diagnosis and assessment of effectiveness of surgical resection

Mato Prado,M, PhD student - MicroRNAs as bile-based biomarkers for pancreatic and biliary tract cancers

Upton,F, MRes - Plasma EVs as biomarkers for Pancreaticobiliary cancers