Imperial College London


Faculty of MedicineDepartment of Surgery & Cancer

Chair in Endocrine Surgery



+44 (0)20 3313 3210a.frilling




BN2/13 B BlockHammersmith HospitalHammersmith Campus





Medical Training

1981                Doctor of Medicine - PhD degree “summa cum laude”

1976 - 1980     University Duisburg-Essen, Medical School, Essen, Germany

1974 - 1976     Ruhr University Bochum, Medical School, Bochum, Germany

 MD/PhD Thesis: “ X-linked Dominant Inheritance of Phosphorylase Kinase Deficiency in Mouse”, Ruhr University Bochum, Medical School Bochum, Germany

 Clinical and Faculty Appointments, Qualifications

2012                Fellow of the Royal College of Surgeons

2011                Fellow of the European Board of Surgery (FEBS) in Endocrine Surgery

1997                Fellow of the American College of Surgeons (FACS)

1995                Degree of Full Professor of Surgery, University of Hamburg, Hamburg, Germany


Professional Memberships and Offices Assumed (selection)

  • German Society of Surgery
  • International Association of Endocrine Surgeons
  • British Association of Endocrine Surgeons
  • American College of Surgeons
  • American Association of Endocrine Surgeons
  • European Chapter of the International Hepato-Pancreato- Biliary Association
  • Founding member and Vice President of UEMS / HPB Working Group
  • European Neuroendocrine Tumor Society


Professional and Academic Administrative Assignments (selection)

  • Head of ENETS Center of Excellence for GEP Neuroendocrine Tumors Imperial College London NHS Member of the task force group “NET” , USA
  • NET Clinical Advisory Board Member, USA
  • External Reviewer for the Research Assessment Exercise (RAE) 2014 of the University Hong Kong, HK
  • Expert Reviewer of the German Research Foundation (DFG)


Reviews, Editorial Work (selection)

  • Reviewer “Proteome Science”
  • Reviewer “American Journal of Medical Genetics”
  • Reviewer “Clinical Endocrinology and Metabolism”
  • Reviewer “British Journal of Surgery”
  • Reviewer “Annals of Surgery”


Basic Research

  • Role of microRNAs in intestinal NETs
  • Metabolic phenotyping in neuroendocrine tumors
  • Genome-wide studies in NETs
  • Tissue marker (proliferation, apoptosis) in neuroendocrine tumors
  • Impact of KIT and PDGFRA mutations on prognosis of GIST
  • Follicular thyroid tumors, three-gene signature, role of microRNAs in carcinogenesis of thyroid tumors
  • Hereditary medullary cancer, identification for specific somatic and hereditary RET protooncogene mutations, genotype-phenotype correlation


Clinical Research

  • Multimodal treatment of neuroendocrine liver metastases and advanced NETs
  • Molecular imaging techniques in NET
  • Biobank for NETs


List of publications (selction)

  1. Frilling A, Malago M, Weber F, Paul A, Nadalin S, Sotiropoulos GC, Cicinnati V, Bockisch A, Mueller-Brand J, Hofmann M, Schmid KW, Gerken G, Broelsch CE (2006). Liver transplantation for patients with metastatic endocrine tumors. Single center experience with 15 patients. Liver Transpl, 12:1089
  2. 2.      Frilling A, Weber F, Saner F, Bockisch A, Hofmann M, Mueller-Brand J, Broelsch CE (2006). Treatment with (90)Y- and (177)Lu-DOTATOC in patients with metastatic neuroendocrine tumors. Surgery, 140:968
  3. 3.      Weber F, Teresi RE, Broelsch CE, Frilling A*, Eng C* (2006). A limited set of human microRNA is deregulated in follicular thyroid carcinoma. J Clin Endocrinol Metab, 91:3584
  4. 4.      Frilling A, Li J, Weber F, Frühauf NR, Engel J, Beckebaum S, Paul A, Zöpf T, Malago M, Broelsch CE (2004). Major bile duct injuries after laparoscopic cholecystectomy: a tertiary center experience. J Gastrointest Surg, 8:679
  5. 5.      Schmitt M, Horbach A, Kubitz R, Frilling A*, Häussinger D* (2004).
    Frilling A, Li J, Malamutmann E, Weber F, Cicinnati V, Nicolas V, Schmid KW, Bockisch A, Mann K, Broelsch CE (2009). Aggressive treatment of liver metastases of neuroendocrine tumours in relation to the different types of hepatic metastatic disease extent: a single center study on 119 patients. Br J Surg, 96:175
  6. 6.      Hou YY, Grabellus F, Weber F, Zhou Y, Tan Y-S, Li J, Shen KT, Qin J, Sun YH, Qin XY, Bockhorn M, Gerken G, Broelsch CE, Frilling A (2009). Impact of KIT and PDGFRA gene mutations on prognosis of patients with gastrointestinal stromal tumors after complete primary tumor resection. J Gastroenterol Surg, 13:1583
  7. 7.      Sarquis MS, Weber F, Shen L, Broelsch CE, Jhinag SM, Zedenius J, Frilling A*,  Eng C* (2006). High frequency of loss-of-heterozygosity in imprinted compared to non-imprinted genomic regions in follicular thyroid carcinomas and atypical adenomas. J Clin Endocrinol Metab, 91:262
  8.   Frilling A, Sotiropoulos GC, Radtke A, Malago M, Bockisch A, Kuehl H, Li J, Broelsch CE (2010) The impact of 68Ga-DOTATOC positron emission tomography/computed tomography on the multimodal management of patients with neuroendocrine tumors. Ann Surg,  252:850




Clift AK, Kornasiewicz O, Drymousis P, et al., 2018, Goblet cell carcinomas of the appendix: rare but aggressive neoplasms with challenging management., Endocr Connect, Vol:7, ISSN:2049-3614, Pages:268-277

Iacovazzo D, Flanagan SE, Walker E, et al., 2018, MAFA missense mutation causes familial insulinomatosis and diabetes mellitus, Proceedings of the National Academy of Sciences of the United States of America, Vol:115, ISSN:0027-8424, Pages:1027-1032

Carter P, Alifrangis C, Cereser B, et al., 2018, Assessing tumor molecular profiling to guide treatments for patients with advanced female genital tract malignancy., Oncotarget, Vol:9, Pages:6007-6014

Ronot M, Clift AK, Baum RP, et al., 2018, Morphological and Functional Imaging for Detecting and Assessing the Resectability of Neuroendocrine Liver Metastases, Neuroendocrinology, Vol:106, ISSN:0028-3835, Pages:74-88

Pawa N, Clift AK, Osmani H, et al., 2017, Surgical Management of Patients with Neuroendocrine Neoplasms of the Appendix: Appendectomy or More?, Neuroendocrinology

More Publications