Imperial College London
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ProfessorAzraGhani

Faculty of Medicine, School of Public Health

Chair in Infectious Disease Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 5764a.ghani Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Verity:2020:10.1038/s41467-020-15779-8,
author = {Verity, R and Aydemir, O and Brazeau, NF and Watson, OJ and Hathaway, NJ and Mwandagalirwa, MK and Marsh, PW and Thwai, K and Fulton, T and Denton, M and Morgan, AP and Parr, JB and Tumwebaze, PK and Conrad, M and Rosenthal, PJ and Ishengoma, DS and Ngondi, J and Gutman, J and Mulenga, M and Norris, DE and Moss, WJ and Mensah, BA and Myers-Hansen, JL and Ghansah, A and Tshefu, AK and Ghani, AC and Meshnick, SR and Bailey, JA and Juliano, JJ},
doi = {10.1038/s41467-020-15779-8},
journal = {Nature Communications},
pages = {1--10},
title = {The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC.},
url = {http://dx.doi.org/10.1038/s41467-020-15779-8},
volume = {11},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic structure of the parasite population in that country. We sequence 2537 Plasmodium falciparum infections, including a nationally representative population sample from DRC and samples from surrounding countries, using molecular inversion probes - a high-throughput genotyping tool. We identify an east-west divide in haplotypes known to confer resistance to chloroquine and sulfadoxine-pyrimethamine. Furthermore, we identify highly related parasites over large geographic distances, indicative of gene flow and migration. Our results are consistent with a background of isolation by distance combined with the effects of selection for antimalarial drug resistance. This study provides a high-resolution view of parasite genetic structure across a large country in Africa and provides a baseline to study how implementation programs may impact parasite populations.
AU  - Verity,R
AU  - Aydemir,O
AU  - Brazeau,NF
AU  - Watson,OJ
AU  - Hathaway,NJ
AU  - Mwandagalirwa,MK
AU  - Marsh,PW
AU  - Thwai,K
AU  - Fulton,T
AU  - Denton,M
AU  - Morgan,AP
AU  - Parr,JB
AU  - Tumwebaze,PK
AU  - Conrad,M
AU  - Rosenthal,PJ
AU  - Ishengoma,DS
AU  - Ngondi,J
AU  - Gutman,J
AU  - Mulenga,M
AU  - Norris,DE
AU  - Moss,WJ
AU  - Mensah,BA
AU  - Myers-Hansen,JL
AU  - Ghansah,A
AU  - Tshefu,AK
AU  - Ghani,AC
AU  - Meshnick,SR
AU  - Bailey,JA
AU  - Juliano,JJ
DO  - 10.1038/s41467-020-15779-8
EP  - 10
PY  - 2020///
SN  - 2041-1723
SP  - 1
TI  - The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC.
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-020-15779-8
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32355199
UR  - https://www.nature.com/articles/s41467-020-15779-8
UR  - http://hdl.handle.net/10044/1/79378
VL  - 11
ER  -
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