Angelika Gründling is a Professor in Molecular Microbiology at Imperial College London, where she started her independent research career in 2007. The research focuses onthe investigation of fundamental processes that are essential for the growth of Gram-positive bacterial pathogens. She combines genetic, biochemical and in collaborations structural approaches to provide mechanistic insight into cell wall synthesis and nucleotide signalling pathways in Staphylococcus aureus and Listeria monocytogenes.Angelika obtained her Ph.D. in Microbiology from the University of Vienna in 2000. She performed her postdoctoral training at the Harvard Medical School, where she investigated flagallar motility in the bacterial pathogen Listeria monocytogenes and at the University of Chicago, where she initiated her studies on the cell wall of S. aureus. At Imperial College London she continues her work on the bacterial cell wall and more recently on the essential signalling nucleotide c-di-AMP.
et al., 2016, The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone, Mbio, Vol:7, ISSN:2150-7511
et al., 2016, New Insights into the Cyclic di-Adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic-Dinucleotide for Acid Stress Resistance in Staphylococcus aureus., Journal of Biological Chemistry, Vol:291, ISSN:1083-351X, Pages:26970-26986
et al., 2016, ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria, Proceedings of the National Academy of Sciences of the United States of America, Vol:113, ISSN:0027-8424, Pages:E1710-E1719
Grundling A, Lee VT, 2016, Old concepts, new molecules and current approaches applied to the bacterial nucleotide signalling field, Philosophical Transactions of the Royal Society B-biological Sciences, Vol:371, ISSN:0962-8436
et al., 2016, Bacterial Signal Transduction by Cyclic Di-GMP and Other Nucleotide Second Messengers, Journal of Bacteriology, Vol:198, ISSN:0021-9193, Pages:15-26