Imperial College London


Central FacultyEducation Office

Taught Postgraduate







250Medical SchoolSt Mary's Campus





Publication Type

10 results found

Ahmed A, Hakim A, Becker A, 2018, Evaluation of eczema, asthma, allergic rhinitis and allergies among the Grade-1 children of Iqaluit, ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, Vol: 14, ISSN: 1710-1484


Hakim A, Khan Y, Esteban I, Miller-Larsson A, Barnes P, Usmani Oet al., 2016, Effects of a single inhaled budesonide/formoterol dose on glucocorticoid receptor activity in sputum of COPD patients, Pages: OA3313-OA3313, ISSN: 0903-1936


Hakim A, Barnes PJ, Adcock IM, Usmani OSet al., 2015, THE IMPACT OF DRUG CLEARANCE ON DURATION OF ACTION OF CORTICOSTEROIDS, Publisher: MARY ANN LIEBERT, INC, Pages: A22-A22, ISSN: 1941-2711


Hakim A, Usmani OS, 2015, Enhancing nuclear translocation: perspectives in inhaled corticosteroid therapy, THERAPEUTIC DELIVERY, Vol: 6, Pages: 443-451, ISSN: 2041-5990


Hakim A, Usmani OS, 2014, Structure of the Lower Respiratory Tract, Reference Module in Biomedical Research, ISBN: 9780128012383

© 2014 Elsevier Inc. All rights reserved.The respiratory system is essential for supplying the body with oxygen and removing carbon dioxide. It is mainly responsible for pulmonary ventilation, movement of air into and out of the lungs, and external respiration. The respiratory system consists of the chest wall structures responsible for moving air in and out of the lungs and the airways that carry the air to the alveoli, which are the gas exchanging region of the lung. The airways themselves are subdivided into two major regions, the upper and lower respiratory tracts. The lower respiratory tract includes the larynx, trachea, bronchi, bronchioles, and alveoli. These structural features facilitate maximum delivery of air to all parts of the lungs as well as providing maximal surface area for gaseous exchange, which is aided by the richly perfused source of blood and lymphatic vessels.


Khan YM, Hakim A, Down G, Burns J, Usmani Oet al., 2014, Novel Engineered Drug Formulations Of beta 2-Agonist And Corticosteroid Reduce LPS-Induced Inflammation In A Human Monocytic Cell Line (thp-1)


Hakim A, Barnes PJ, Adcock IM, Usmani OSet al., 2013, Importin-7 mediates glucocorticoid receptor nuclear import and is impaired by oxidative stress, leading to glucocorticoid insensitivity, FASEB JOURNAL, Vol: 27, Pages: 4510-4519, ISSN: 0892-6638


Haque R, Hakim A, Moodley T, Torrego A, Essilfie-Quaye S, Jazrawi E, Johnson M, Barnes PJ, Adcock IM, Usmani OSet al., 2013, Inhaled long-acting beta(2) agonists enhance glucocorticoid receptor nuclear translocation and efficacy in sputum macrophages in COPD, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 132, Pages: 1166-1173, ISSN: 0091-6749


Hakim A, Adcock IM, Usmani OS, 2012, Corticosteroid Resistance and Novel Anti-Inflammatory Therapies in Chronic Obstructive Pulmonary Disease Current Evidence and Future Direction, DRUGS, Vol: 72, Pages: 1299-1312, ISSN: 0012-6667


Mercado N, Hakim A, Kobayashi Y, Meah S, Usmani OS, Chung KF, Barnes PJ, Ito Ket al., 2012, Restoration of Corticosteroid Sensitivity by p38 Mitogen Activated Protein Kinase Inhibition in Peripheral Blood Mononuclear Cells from Severe Asthma, PLOS ONE, Vol: 7, ISSN: 1932-6203


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