Imperial College London
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ProfessorAdamHampshire

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 7993a.hampshire

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Grant:2018:10.1176/appi.neuropsych.18030038,
author = {Grant, JE and Daws, R and Hampshire, A and Chamberlain, SR},
doi = {10.1176/appi.neuropsych.18030038},
journal = {J Neuropsychiatry Clin Neurosci},
pages = {318--324},
title = {An fMRI Pilot Study of Cognitive Flexibility in Trichotillomania.},
url = {http://dx.doi.org/10.1176/appi.neuropsych.18030038},
volume = {30},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Trichotillomania is a relatively common psychiatric condition, although its neurobiological basis is unknown. Abnormalities of flexible responding have been implicated in the pathophysiology of obsessive-compulsive disorder and thus may be relevant in trichotillomania. The purpose of this study was to probe reversal learning and attentional set-shifting in trichotillomania. Twelve adults with trichotillomania and 13 matched healthy control subjects undertook a functional MRI task of cognitive flexibility. Group-level activation maps for extradimensional and reversal switches were independently parcellated into discrete regions of interest using a custom watershed algorithm. Activation magnitudes were extracted from each region of interest and study subject and compared at the group level. Reversal events evoked the expected patterns of insula and parietal regions and activity in the frontal dorsal cortex extending anterior to the frontal poles, whereas extradimensional shifts evoked the expected frontal dorsolateral and parietal pattern of activity. Trichotillomania was associated with significantly increased right middle frontal and reduced right occipital cortex activation during reversal and set-shifting. Elevated frontal activation coupled with reduced activation in more posterior brain regions was identified. These pilot data suggest potentially important neural dysfunction associated with trichotillomania.
AU  - Grant,JE
AU  - Daws,R
AU  - Hampshire,A
AU  - Chamberlain,SR
DO  - 10.1176/appi.neuropsych.18030038
EP  - 324
PY  - 2018///
SP  - 318
TI  - An fMRI Pilot Study of Cognitive Flexibility in Trichotillomania.
T2  - J Neuropsychiatry Clin Neurosci
UR  - http://dx.doi.org/10.1176/appi.neuropsych.18030038
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30141727
VL  - 30
ER  -
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