Imperial College London
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ProfessorAnnaHansell

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

a.hansell

 
 
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Location

 

UG42Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wain:2017:10.1038/ng.3787,
author = {Wain, LV and Shrine, N and Artigas, MS and Erzurumluoglu, AM and Noyvert, B and Bossini-Castillo, L and Obeidat, M and Henrys, AP and Portelli, MA and Hall, RJ and Billington, CK and Rimington, TL and Fenech, AG and John, C and Blake, T and Jackson, VE and Allen, RJ and Prins, BP and Campbell, A and Porteous, DJ and Jarvelin, M-R and Wielscher, M and Jamess, AL and Hui, J and Wareham, NJ and Zhao, JH and Wilson, JF and Joshi, PK and Stubbe, B and Rawal, R and Schulz, H and Imboden, M and Probst-Hensch, NM and Karrasch, S and Gieger, C and Deary, IJ and Harris, SE and Marten, J and Rudan, I and Enroth, S and Gyllensten, U and Kerr, SM and Polasek, O and Kahonen, M and Surakka, I and Vitart, V and Hayward, C and Lehtimaki, T and Raitakari, OT and Evans, DM and Henderson, AJ and Pennell, CE and Wang, CA and Sly, PD and Wan, ES and Busch, R and Hobbs, BD and Litonjua, AA and Sparrow, DW and Gulsvik, A and Bakke, PS and Crapo, JD and Beaty, TH and Hansel, NN and Mathias, RA and Ruczinski, I},
doi = {10.1038/ng.3787},
journal = {Nature Genetics},
pages = {416--425},
title = {Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets},
url = {http://dx.doi.org/10.1038/ng.3787},
volume = {49},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function distribution in UK Biobank, and follow-up in 95,375 individuals, we increased the yield of independent signals for lung function from 54 to 97. A genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (~6 alleles) (95% confidence interval) = 1.24 (1.20–1.27), P = 5.05 × 10−49), and we observed a 3.7-fold difference in COPD risk between individuals in the highest and lowest genetic risk score deciles in UK Biobank. The 97 signals show enrichment in genes for development, elastic fibers and epigenetic regulation pathways. We highlight targets for drugs and compounds in development for COPD and asthma (genes in the inositol phosphate metabolism pathway and CHRM3) and describe targets for potential drug repositioning from other clinical indications.
AU  - Wain,LV
AU  - Shrine,N
AU  - Artigas,MS
AU  - Erzurumluoglu,AM
AU  - Noyvert,B
AU  - Bossini-Castillo,L
AU  - Obeidat,M
AU  - Henrys,AP
AU  - Portelli,MA
AU  - Hall,RJ
AU  - Billington,CK
AU  - Rimington,TL
AU  - Fenech,AG
AU  - John,C
AU  - Blake,T
AU  - Jackson,VE
AU  - Allen,RJ
AU  - Prins,BP
AU  - Campbell,A
AU  - Porteous,DJ
AU  - Jarvelin,M-R
AU  - Wielscher,M
AU  - Jamess,AL
AU  - Hui,J
AU  - Wareham,NJ
AU  - Zhao,JH
AU  - Wilson,JF
AU  - Joshi,PK
AU  - Stubbe,B
AU  - Rawal,R
AU  - Schulz,H
AU  - Imboden,M
AU  - Probst-Hensch,NM
AU  - Karrasch,S
AU  - Gieger,C
AU  - Deary,IJ
AU  - Harris,SE
AU  - Marten,J
AU  - Rudan,I
AU  - Enroth,S
AU  - Gyllensten,U
AU  - Kerr,SM
AU  - Polasek,O
AU  - Kahonen,M
AU  - Surakka,I
AU  - Vitart,V
AU  - Hayward,C
AU  - Lehtimaki,T
AU  - Raitakari,OT
AU  - Evans,DM
AU  - Henderson,AJ
AU  - Pennell,CE
AU  - Wang,CA
AU  - Sly,PD
AU  - Wan,ES
AU  - Busch,R
AU  - Hobbs,BD
AU  - Litonjua,AA
AU  - Sparrow,DW
AU  - Gulsvik,A
AU  - Bakke,PS
AU  - Crapo,JD
AU  - Beaty,TH
AU  - Hansel,NN
AU  - Mathias,RA
AU  - Ruczinski,I
AU  - Barnes,KC
AU  - Bosse,Y
AU  - Joubert,P
AU  - van,den Berge M
AU  - Brandsma,C-A
AU  - Pare,PD
AU  - Sin,DD
AU  - Nickle,DC
AU  - Hao,K
AU  - Gottesman,O
AU  - Dewey,FE
AU  - Bruse,SE
AU  - Carey,DJ
AU  - Kirchner,HL
AU  - Jonsson,S
AU  - Thorleifsson,G
AU  - Jonsdottir,I
AU  - Gislason,T
AU  - Stefansson,K
AU  - Schurmann,C
AU  - Nadkarni,G
AU  - Bottinger,EP
AU  - Loos,RJF
AU  - Walters,RG
AU  - Chen,Z
AU  - Millwood,IY
AU  - Vaucher,J
AU  - Kurmi,OP
AU  - Li,L
AU  - Hansell,AL
AU  - Brightling,C
AU  - Zeggini,E
AU  - Cho,MH
AU  - Silverman,EK
AU  - Sayers,I
AU  - Trynka,G
AU  - Morris,AP
AU  - Strachan,DP
AU  - Halls,IP
AU  - Tobin,MD
DO  - 10.1038/ng.3787
EP  - 425
PY  - 2017///
SN  - 1061-4036
SP  - 416
TI  - Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
T2  - Nature Genetics
UR  - http://dx.doi.org/10.1038/ng.3787
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000394917800015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/48166
VL  - 49
ER  -
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